Gastrointestinal Biomarkers and Animal Health

  • ZHOU Liyuan ,
  • LI Chengliang ,
  • LI Siyuan ,
  • FANG Rejun
Expand
  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2019-05-27

  Online published: 2019-12-13

Abstract

It is very important for animal production performance and health that to have a strong gastrointestinal function. Gastrointestinal biomarkers can be used to monitor the development and severity of gastrointestinal diseases in animals which play an important role in animal feeding. There are many factors affecting the gastrointestinal health of animals, moreover, every factor is closely related to each other. Due to a limited reflect of gastrointestinal health status by single gastrointestinal biomarker, the development the variety of gastrointestinal biomarkers is of great significance. This paper introduced some gastrointestinal biomarkers, by analyzing their effectiveness, credibility and applicability, aiming to provide scientific basis for effective screening of gastrointestinal biomarkers and healthy animal production.

Cite this article

ZHOU Liyuan , LI Chengliang , LI Siyuan , FANG Rejun . Gastrointestinal Biomarkers and Animal Health[J]. Chinese Journal of Animal Nutrition, 2019 , 31(12) : 5476 -5484 . DOI: 10.3969/j.issn.1006-267x.2019.12.012

References

[1] KOGUT M H,ARSENAULT R J.Editorial:gut health:the new paradigm in food animal production[J].Frontiers in Veterinary Science,2016,3:71.
[2] 李玉龙,杨欣,杨小军.家禽肠道健康营养调控研究进展[C]//中国畜牧兽医学会动物营养学分会第十届全国代表大会暨十二届学术研讨会论文集.武汉:中国农业大学出版社,2016:100-108.
[3] KÅHRSTROM C T,PARIENTE N,WEISS U.Intestinal microbiota in health and disease[J].Nature,2016,535(7610):47.
[4] LEE W J,HASE K.Gut microbiota-generated metabolites in animal health and disease[J].Nature Chemical Biology,2014,10(6):416-424.  
[5] MARCHESI J R,ADAMS D H,FAVA F,et al.The gut microbiota and host health:a new clinical frontier[J].Gut,2016,65(2):330-339.  
[6] DIETERT R R,SILBERGELD E K.Biomarkers for the 21st century:listening to the microbiome[J].Toxicological Sciences,2015,144(2):208-216.  
[7] THE HUMAN MICROBIOME PROJECT CONSORTIUM.Structure,function and diversity of the healthy human microbiome[J].Nature,2012,486(7402):207-214.  
[8] OU J Z,YAO C K,ROTBART A,et al.Human intestinal gas measurement systems:in vitro fermentation and gas capsules[J].Trends in Biotechnology,2015,33(4):208-213.  
[9] WIKOFF W R,ANFORA A T,LIU J,et al.Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites[J].Proceedings of the National Academy of Sciences of the United States of America,2009,106(10):3698-3703.  
[10] CELI P,VERLHAC V,PÉREZ C,et al.Biomarkers of gastrointestinal functionality in animal nutrition and health[J].Animal Feed Science and Technology,2019,250:9-31.
[11] 杨利娜,边高瑞,朱伟云.单胃动物肠道微生物菌群与肠道免疫功能的相互作用[J].微生物学报,2014,54(5):480-486.
[12] ARIAKE K,OHKUSA T,SAKURAZAWA T,et al.Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice[J].Journal of Medical and Dental Sciences,2000,47(4):233-241.
[13] WU Q J,ZHOU Y M,WU Y N,et al.The effects of natural and modified clinoptilolite on intestinal barrier function and immune response to LPS in broiler chickens[J].Veterinary Immunology and Immunopathology,2013,153(1/2):70-76.
[14] 韩杰,张一然,张飞,等.刺五加多糖对免疫应激断奶仔猪血浆D-乳酸水平和腹泻状况的影响[J].现代畜牧兽医,2016(1):18-22.
[15] XUN W J,SHI L G,ZHOU H L,et al.Effects of curcumin on growth performance,jejunal mucosal membrane integrity,morphology and immune status in weaned piglets challenged with enterotoxigenic Escherichia coli[J].International Immunopharmacology,2015,27(1):46-52.  
[16] 王丽晶,孙莹杰,刁玉刚,等.七氟烷预处理对失血性休克猪血浆肠脂肪酸结合蛋白、D-乳酸浓度和细菌移位的影响[J].实用药物与临床,2015,18(11):1271-1275.
[17] JHA R,BERROCOSO J F D.Dietary fiber and protein fermentation in the intestine of swine and their interactive effects on gut health and on the environment:a review[J].Animal Feed Science and Technology,2016,212:18-26.
[18] ANDRIAMIHAJA M,LAN A,BEAUMONT M,et al.The deleterious metabolic and genotoxic effects of the bacterial metabolite p-cresol on colonic epithelial cells[J].Free Radical Biology and Medicine,2015,85:219-227.
[19] PATURI G,NYANHANDA T,BUTTS C A,et al.Effects of potato fiber and potato-resistant starch on biomarkers of colonic health in rats fed diets containing red meat[J].Journal of Food Science,2012,77(10):H216-H223.
[20] MIYAZAKI K,MASUOKA N,KANO M,et al.Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota[J].Beneficial Microbes,2014,5(2):121-128.  
[21] MUSZYNSKA B,GRZYWACZ-KISIELEWSKA A,KALA K,et al.Anti-inflammatory properties of edible mushrooms:a review[J].Food Chemistry,2018,243:373-381.
[22] ZELANTE T,IANNITTI R,CUNHA C,et al.Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22[J].Immunity,2013,39(2):372-385.  
[23] VELTHOF G L,HOU Y,OENEMA O.Nitrogen excretion factors of livestock in the European Union:a review[J].Journal of the Science of Food and Agriculture,2015,95(15):3004-3014.  
[24] RINTTILÄ T,APAJALAHTI J.Intestinal microbiota and metabolites-implications for broiler chicken health and performance[J].The Journal of Applied Poultry Research,2013,22(3):647-658.  
[25] 朱伟,冯培功,马君军,等.环境温度对肉羊有害气体排放、环境微生物和血清生化指标的影响[J].动物营养学报,2018,30(11):4460-4469.
[26] 马现永,田志梅,邓盾,等.低蛋白饲粮时代来临,我国将全面推广低蛋白饲粮技术[J].广东畜牧兽医科技,2019,44(1):5-7.
[27] KERR B J,WEBER T E,ZIEMER C J,et al.Effect of dietary inorganic sulfur level on growth performance,fecal composition,and measures of inflammation and sulfate-reducing bacteria in the intestine of growing pigs[J].Animal Science,2011,89(2):426-437.  
[28] 梁亚男,姜军坡,王世英,等.Z-27菌剂对猪舍空气NH3、H2S浓度及排泄物含氮量的影响[J].江苏农业科学,2019,47(5):148-153.
[29] 张成玉,王月影,许春梅,等.硫化氢的生成及其在细胞凋亡和炎性反应中的作用[J].中国畜牧兽医,2018,45(12):3402-3407.
[30] FENG S S,CHEN S Y,YU W,et al.H2S inhibits pulmonary arterial endothelial cell inflammation in rats with monocrotaline-induced pulmonary hypertension[J].Laboratory Investigation,2016,97(3):268-278.
[31] WALLACE J L,MOTTA J P,BURET A G.Hydrogen sulfide:an agent of stability at the microbiome-mucosa interface[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2018,314(2):G143-G149.
[32] ZHAO H Y,YAN R,ZHOU X G,et al.Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice[J].International Immunopharmacology,2016,39:121-127.
[33] 吴忠明,卢根林,吴海明,等.硫化氢对肠缺血-再灌注损伤大鼠炎症因子及内毒素血症的影响[J].中华全科医学,2017,15(6):921-923.
[34] 张夏薇,慕春龙,朱伟云.不同浓度硫化氢对肠上皮细胞炎症、氧化应激和线粒体功能的影响[J/OL].南京农业大学学报,[2019-05-23].http://kns.cnki.net/kcms/detail/32.1148.S.20190527.1027.002.html.
[35] 田志梅,蒋宗勇,王丽,等.益生菌的功能及其在生猪养殖产业中的应用[J].动物营养学报,2019,31(3):1020-1030.
[36] CHARBONNEAU M R,BLANTON L V,DIGIULIO D B,et al.A microbial perspective of human developmental biology[J].Nature,2016,535(7610):48-55.  
[37] VIGHI G,MARCUCCI G,SENSI L,et al.Allergy and the gastrointestinal system[J].Clinical & Experimental Immunology,2010,153 Suppl.1:3-6.
[38] 王忠锐,陈红旗,杨俊.乳酸菌对IL-10-/-小鼠肠黏膜屏障损伤修复的机制研究[J].中国现代普通外科进展,2015,18(11):845-850.
[39] KRIVOV S V,FENTON H,GOLDSMITH P J,et al.Optimal reaction coordinate as a biomarker for the dynamics of recovery from kidney transplant[J].PLoS Computational Biology,2014,10(6):e1003685.
[40] MIKI T,OKADA N,HARDT W D.Inflammatory bactericidal lectin RegⅢβ:friend or foe for the host?[J].Gut Microbes,2017:9(2):179-187.
[41] TSUCHIDA C,SAKURAMOTO-TSUCHIDA S,TAKED M,et al.Expression of REG family genes in human inflammatory bowel diseases and its regulation[J].Biochemistry and Biophysics Reports,2017,12:198-205.
[42] LEONARDI I,LI X,SEMON A,et al.CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi[J].Science,2018,359(6372):232-236.  
[43] OGAWA H,FUKUSHIMA K,NAITO H,et al.Increased expression of HIP/PAP and regenerating gene Ⅲ in human inflammatory bowel disease and a murine bacterial reconstitution model[J].Inflammatory Bowel Diseases,2010,9(3):162-170.
[44] SOLER L,MILLER I,NÖBAUER K.Identification of the major regenerative Ⅲ protein (RegⅢ) in the porcine intestinal mucosa as RegIIIγ,not RegⅢα[J].Veterinary Immunology and Immunopathology,2015,167(1/2):51-56.
[45] PULL S L,DOHERTY J M,MILLS J C,et al.Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(1):99-104.  
[46] DIEHL G E,LONGMAN R S,ZHANG J X,et al.Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells[J].Nature,2013,494(7435):116-120.  
[47] MASHIKO M,KUROSAWA A,TANI Y.GPR31 and GPR151 are activated under acidic conditions[J].The Journal of Biochemistry,2019:mvz042,doi:10.1093/jb/mvz042.
[48] 吴小平,莫雅娴.炎症性肠病非侵入性标志物研究进展[J].国际消化病杂志,2009,29(1):61-64.
[49] 武琳琳,帅宗文,胡子盈,等.髓过氧化物酶-抗中性粒细胞胞浆抗体相关性血管炎活动期血清标志物的研究[J].医学研究生学报,2015,28(4):406-410.
[50] ARIMURA Y,KAWASHIMA S,YOSHIHARA K,et al.The role of myeloperoxidase and myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCAs) in the pathogenesis of human MPO-ANCA-associated glomerulonephritis[J].Clinical and Experimental Nephrology,2013,17(5):634-637.  
[51] PEARCE S C,MANI V,BODDICKER R L,et al.Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs[J].PLoS One,2013,8(8):e70215.
[52] YOUNG D,IBUKI M,NAKAMORI T,et al.Soy-derived di- and tripeptides alleviate colon and ileum inflammation in pigs with dextran sodium sulfate-induced colitis[J].The Journal of Nutrition,2012,142(2):363-368.  
[53] JANG S E,LIM S M,JEONG J J,et al.Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice[J].Mucosal Immunology,2018,11(2):369-379.  
[54] KOSEK M,HAQUE R,LIMA A,et al.Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants[J].The American Journal of Tropical Medicine and Hygiene,2013,88(2):390-396.  
[55] AL-HADDAD S,RIDDELL R H.The role of eosinophils in inflammatory bowel disease[J].Gut,2005,54(12):1674-1675.  
[56] PETERSON C G B,LAMPINEN M,HANSSON T,et al.Evaluation of biomarkers for ulcerative colitis comparing two sampling methods:fecal markers reflect colorectal inflammation both macroscopically and on a cellular level[J].Scandinavian Journal of Clinical and Laboratory Investigation,2016,76(5):393-401.  
[57] WAGNER M,SJÖBERG K,VIGREN L,et al.Elevated fecal levels of eosinophil granule proteins predict collagenous colitis in patients referred to colonoscopy due to chronic non-bloody diarrhea[J].Scandinavian Journal of Gastroenterology,2016,51(7):835-841.  
[58] 刘绍琼.mTOR信号通路在LPS诱导肉鸡肠道黏膜免疫应激中的作用[D].博士学位论文.泰安:山东农业大学,2015.
[59] 黄登桂,周加义,高春起,等.产肠毒素大肠杆菌对仔猪肠道黏膜屏障功能的影响及其损伤修复研究进展[J].动物营养学报,2019,31(1):48-56.
[60] 贾军峰,王梦竹,崔一喆,等.脂多糖致炎时间对小鼠血液免疫与肠道组织形态的影响[J].动物营养学报,2018,30(9):3609-3616.
[61] ZIPFEL C.A new receptor for LPS[J].Nature Immunology,2015,16(4):340-341.  
[62] ANDERSON S T,COMMINS S,MOYNAGH P N,et al.Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse[J].Brain,Behavior,and Immunity,2015,43:98-109.
[63] BRUEWER M,LUEGERING A,KUCHARZIK T,et al.Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms[J].The Journal of Immunology,2003,171(11):6164-6172.  
[64] 马兰,常兰.不同海拔藏绵羊小肠上皮内淋巴细胞、杯状细胞的数量和分布比较及其意义[J].青海医学院学报,2012,33(2):99-102.
[65] 李先根,涂治骁,王树辉,等.亚麻籽油对脂多糖刺激断奶仔猪肠黏膜结构和免疫细胞的影响[J].动物营养学报,2018,30(2):515-523.
[66] METZLER-ZEBELI B U,MANN E,SCHMITZ-ESSER S,et al.Changing dietary calcium-phosphorus level and cereal source selectively alters abundance of bacteria and metabolites in the upper gastrointestinal tracts of weaned pigs[J].Applied and Environmental Microbiology,2013,79(23):7264-7272.  
[67] LI S,KHAFIPOUR E,KRAUSE D O,et al.Free endotoxins in the feces of lactating dairy cows[J].Canadian Journal of Animal Science,2010,90(4):591-594.  
[68] KALVAKOLANU D V.Twenty five years of cytokine:on a forward path to exciting discoveries of pathological mechanisms and therapeutics[J].Cytokine,2017,98:1-3.
[69] SUN M,HE C,CONG Y,et al.Regulatory immune cells in regulation of intestinal inflammatory response to microbiota[J].Mucosal Immunology,2015,8(5):969-978.  
[70] STAMATOVIC S M,JOHNSON A M,SLADOJEVIC N,et al.Endocytosis of tight junction proteins and the regulation of degradation and recycling[J].Annals of the New York Academy of Sciences,2017,1397(1):54-65.  
[71] GAO Y,HAN F,HUANG X,et al.Changes in gut microbial populations,intestinal morphology,expression of tight junction proteins,and cytokine production between two pig breeds after challenge with Escherichia coli K88:a comparative study[J].Journal of Animal Science,2013,91(12):5614-5625.  
[72] 崔畅婉,孙峥嵘.溃疡性结肠炎发病机制研究进展[J].现代免疫学,2019,39(1):77-81.
[73] EISSA N,HUSSEIN H,KERMARREC L,et al.Chromofungin ameliorates the progression of colitis by regulating alternatively activated macrophages[J].Frontiers in Immunology,2017,8(3):1131-1133.
[74] 胡艺丽,李媛媛,杨勤.溃疡性结肠炎黏膜愈合相关生物标志物的研究进展[J].实用医学杂志,2018,34(21):3644-3647.
[75] JOHNSON J L,JONES M B,COBB B A.Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation[J].Glycobiology,2015,25(4):368-375.  
[76] WELLS J M,BRUMMER R J,DERRIEN M,et al.Homeostasis of the gut barrier and potential biomarkers[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2017,312(3):G171-G193.
[77] 洪南.肠道微生态系统与肠黏膜免疫关系研究进展[J].医学研究生学报,2014,27(4):444-446.
[78] 韩渤,刘玥宏,仇志强,等.sIgA表达功能及其在肠道疾病的作用[J].世界华人消化杂志,2017,25(19):1757-1763.
[79] KIM J C,HANSEN C F,MULLAN B P,et al.Nutrition and pathology of weaner pigs:nutritional strategies to support barrier function in the gastrointestinal tract[J].Animal Feed Science and Technology,2012,173(1/2):3-16.
[80] WU S D,ZHANG F R,HUANG Z M,et al.Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli[J].Peptides,2012,35(2):225-230.  
[81] IBUKI M,KOVACS-NOLAN J,FUKUI K,et al.Analysis of gut immune-modulating activity of β-1,4-mannobiose using microarray and real-time reverse transcription polymerase chain reaction[J].Poultry Science,2010,89(9):1894-1904.  
[82] KONSTANTINOV S R,SMIDT H,AKKERMANS A D L,et al.Feeding of Lactobacillus sobrius reduces Escherichia coli F4 levels in the gut and promotes growth of infected piglets[J].FEMS Microbiology Ecology,2008,66(3):599-607.  
Outlines

/