Hypoglycemic and Hypolipidemic Effects and Mechanisms of Flavonoids from Mulberry Leaves and Its Application in Animal Production

FENG Ganyi; LIU Yingying; LI Yinghui; ZHOU Ling

doi:10.3969/j.issn.1006-267x.2020.01.008

2020 , Vol. 32 >Issue 1: 48 - 53

DOI: https://doi.org/10.3969/j.issn.1006-267x.2020.01.008

Hypoglycemic and Hypolipidemic Effects and Mechanisms of Flavonoids from Mulberry Leaves and Its Application in Animal Production

FENG Ganyi ,
LIU Yingying ,
LI Yinghui ,
ZHOU Ling

Expand

1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
2. The Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
3. Hunan Institute of Animal and Veterinary Science, Changsha 410131, China

Received date: 2019-07-17

Online published: 2020-01-19

Supported by

Fold

Abstract

Mulberry leaf, a kind of medicine and food homology plant resource, is widely distributed in China. It contains several natural active ingredients, such as flavonoids, alkaloids, amino acids, polysaccharides and steroids. These active ingredients have many physiological functions, such as lowering blood sugar and lipids, anti-virus, inhibiting tumors and so on. The content of flavonoids in mulberry leaves is abundant, so the study of their biological activities is becoming one of the hottest topics. Starting with the extraction methods of flavonoids from mulberry leaves, the hypoglycemic and hypolipidemic effects and mechanisms of flavonoids from mulberry leaves and its application in animal production were reviewed in this paper, which can provide a reference for the application of flavonoid-rich mulberry leaves as a new and green feed resource or additive in animal husbandry.

Key words： flavonoids from mulberry leaves; extraction method; hypoglycemia; hypolipidemic; animal production

Cite this article

FENG Ganyi , LIU Yingying , LI Yinghui , ZHOU Ling . Hypoglycemic and Hypolipidemic Effects and Mechanisms of Flavonoids from Mulberry Leaves and Its Application in Animal Production[J]. Chinese Journal of Animal Nutrition, 2020 , 32(1) : 48 -53 . DOI: 10.3969/j.issn.1006-267x.2020.01.008

References

[1] 刘春连.桑叶的化学成分及降血糖作用的研究进展[J].农产品加工,2019(9):79-80,86.
[2] 王婷婷,马天宇,李琪,等.桑叶化学成分及生物活性研究进展[J].食品与药品,2018,20(5):390-393.
[3] 李飞鸣,张国平,邹湘月,等.桑叶黄酮类化合物研究进展[J].中国蚕业,2015,36(2):1-4,10.
[4] KIM S Y,GAO J J,LEE W C,et al.Antioxidative flavonoids from the leaves of Morus alba[J].Archives of Pharmacal Research,1999,22(1):81-85.

[5] DOI K,KOJIMA T,MAKINO M,et al.Studies on the constituents of the leaves of Morus alba L.[J].Chemical and Pharmaceutical Bulletin,2001,49(2):151-153.

[6] JU W T,KWON O C,KIM H B,et al.Qualitative and quantitative analysis of flavonoids from 12 species of Korean mulberry leaves[J].Journal of Food Science and Technology,2018,55(5):1789-1796.

[7] 杨继华,曹俊明,陈冰,等.桑叶黄酮类化合物提取纯化、生物学功能研究进展[J].广东畜牧兽医科技,2018,43(3):9-15.
[8] 许佳明,赵安琦,谢静,等.应用高效逆流色谱分离桑叶黄酮类化合物[J].分析试验室,2019,38(3):266-269.
[9] 张贵会,王贺,杨玲.药桑叶黄酮类成分的研究[J].中成药,2017,39(4):765-769.
[10] 吴恢,孙波,李祖发,等.桑叶黄酮含量测定及提取工艺研究进展[J].蚕桑通报,2011,42(4):4-7.
[11] 陈雨微,徐茂义,赵丰权,等.桑叶黄酮类化合物提取工艺及其降血糖作用研究进展[J].中华中医药学刊,2012,30(9):2084-2088.
[12] 薛淑萍,张立伟.桑叶中黄酮类化合物的提取工艺的优化[J].中国生化药物杂志,2010,31(6):405-407.
[13] VILKHU K,MAWSON R,SIMONS L,et al.Applications and opportunities for ultrasound assisted extraction in the food industry-a review[J].Innovative Food Science & Emerging Technologies,2008,9(2):161-169.

[14] WANG J,SUN B G,CAO Y P,et al.Optimisation of ultrasound-assisted extraction of phenolic compounds from wheat bran[J].Food Chemistry,2008,106(2):804-810.

[15] 张齐.桑叶黄酮的提取及黄酮类成分桑色素的抗癌活性研究[D].硕士学位论文.合肥:合肥工业大学,2018:19.
[16] 石仝雨,缪伟伟,王志雄.超临界二氧化碳法萃取桑叶中总黄酮工艺研究[J].生物技术进展,2017,7(1):77-84.
[17] 谢玉龙,石仝雨,缪伟伟,等.正交实验法优化超临界二氧化碳萃取桑叶总黄酮[J].生物技术进展,2017,7(4):345-349.
[18] YING Z,HAN X X,LI J R.Ultrasound-assisted extraction of polysaccharides from mulberry leaves[J].Food Chemistry,2011,127(3):1273-1279.

[19] 李文利,宁喜斌,熊梓伊,等.响应面法优化微波提取桑叶黄酮和多糖工艺研究[J].食品工业,2015,36(2):21-25.
[20] 王珂.桑叶黄酮提取纯化及其降血脂作用研究[D].硕士学位论文.上海:华东师范大学,2011:12.
[21] 季涛,宿树兰,郭盛,等.桑叶防治糖尿病的效应成分群及其作用机制研究进展[J].中草药,2015,46(5):778-784.
[22] RICHE D M,RICHE K D,EAST H E,et al.Impact of mulberry leaf extract on type 2 diabetes (Mul-DM):a randomized,placebo-controlled pilot study[J].Complementary Therapies in Medicine,2017,32:105-108.
[23] HONG C T,LIU Z H,HUANG Y T,et al.Extract from mulberry (Morus australis) leaf decelerate acetaminophen induced hepatic inflammation involving downregulation of myeloid differentiation factor 88(MyD88) signals[J].Journal of Food and Drug Analysis,2017,25(4):862-871.

[24] CAI S Y,SUN W,FAN Y X,et al.Effect of mulberry leaf (Folium mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats[J].Pharmaceutical Biology,2016,54(11):2685-2691.

[25] 陈玲玲,刘炜,陈建国,等.桑叶黄酮对糖尿病小鼠调节血糖的作用机制研究[J].中国临床药理学杂志,2010,26(11):835-838.
[26] 黄链莎,刘铜华,孙文,等.桑叶黄酮对糖尿病大鼠血糖水平的影响及机制探讨[J].中国实验方剂学杂志,2018,24(16):152-156.
[27] 薛城敬,苏言辉,王亚洲,等.桑叶黄酮对2型糖尿病并发单纯性脂肪肝大鼠肝组织PPARγ的影响[J].中国现代医生,2014,52(26):1-4.
[28] 朱玉霞,孙丽莎,陈秋.桑叶黄酮对糖尿病单纯性脂肪肝大鼠的治疗作用及其机制探讨[J].山东医药,2015,55(12):27-28.
[29] 寇秀颖,杜阳吉,徐勇.桑叶黄酮类和多糖类化合物的提取及其降血糖作用研究[J].食品工程,2010(4):39-41,48.
[30] 王德萍,鱼晓敏,安馨,等.桑叶多组分协同降血糖作用[J].现代预防医学,2018,45(16):2924-2928.
[31] 徐学君,张秀芳,徐德琴,等.黄酮类化合物调节血脂作用的研究进展[J].中国药房,2016,27(1):114-117.
[32] 江正菊,宁林玲,胡霞敏,等.桑叶总黄酮对高脂诱导大鼠高血脂及高血糖的影响[J].中药材,2011,34(1):108-111.
[33] 江正菊,单琳琳,胡霞敏,等.桑叶总黄酮对大鼠血脂早期干预的实验研究[J].时珍国医国药,2011,22(3):595-596.
[34] 李向荣,陈菁菁,刘晓光.桑叶总黄酮对高脂血症动物的降血脂效应[J].中国药学杂志,2009,44(21):1630-1633.
[35] CHEN J J,LI X R.Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice[J].Asia Pacific Journal of Clinical Nutrition,2007,16(1):290-294.
[36] 陈菁菁.桑叶总黄酮的分离纯化和降血脂作用评价[D].硕士学位论文.杭州:浙江大学,2006:43.
[37] 杨春涛,刁其玉,曲培滨,等.热带假丝酵母菌与桑叶黄酮对犊牛营养物质代谢和瘤胃发酵的影响[J].动物营养学报,2016,28(1):224-234.
[38] WANG B,YANG C T,DIAO Q Y,et al.The influence of mulberry leaf flavonoids and Candida tropicalis on antioxidant function and gastrointestinal development of preweaning calves challenged with Escherichia coli O141:K99[J].Journal of Dairy Science,2018,101(7):6098-6108.

[39] 陈丹丹,屠焰,马涛,等.桑叶黄酮和白藜芦醇对肉羊气体代谢及甲烷排放的影响[J].动物营养学报,2014,26(5):1221-1228.
[40] MA T,CHEN D D,TU Y,et al.Dietary supplementation with mulberry leaf flavonoids inhibits methanogenesis in sheep[J].Animal Science Journal,2017,88(1):72-78.

[41] 陈冰,杨继华,曹俊明,等.桑叶黄酮对吉富罗非鱼肌肉抗氧化指标及营养组成的影响[J].淡水渔业,2018,48(3):90-95.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References