[1] OTT S J,MUSFELDT M,WENDEROTH D F,et al.Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease[J].Gut,2004,53(5):685-693.
[2] COLEMAN O I,HALLER D.Bacterial signaling at the intestinal epithelial interface in inflammation and cancer[J].Frontiers in Immunology,2018,8:1927.
[3] PETERSSON J,SCHREIBER O,HANSSON G C,et al.Importance and regulation of the colonic mucus barrier in a mouse model of colitis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2011,300(2):G327-G333.
[4] LAWLEY T D,WALKER A W.Intestinal colonization resistance[J].Immunology,2013,138(1):1-11.
[5] JIMINEZ J A,UWIERA T C,INGLIS G D,et al.Animal models to study acute and chronic intestinal inflammation in mammals[J].Gut Pathogens,2015,7:29.
[6] MA N,GUO P T,ZHANG J,et al.Nutrients mediate intestinal bacteria-mucosal immune crosstalk[J].Frontiers in Immunology,2018,9:5.
[7] JOHANSSON M E V,PHILLIPSON M,PETERSSON J,et al.The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(39):15064-15069.
[8] PETERSSON J,SCHREIBER O,HANSSON G C,et al.Importance and regulation of the colonic mucus barrier in a mouse model of colitis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2011,300(2):G327-G333.
[9] KOBOZIEV I,KARLSSON F,GRISHAM M B,et al.Gut-associated lymphoid tissue,T cell trafficking,and chronic intestinal inflammation[J].Annals of the New York Academy of Sciences,2010,1207(Suppl.1):E86-E93.
[10] HANSSON J,BOSCO N,FAVRE L,et al.Influence of gut microbiota on mouse B2 B cell ontogeny and function[J].Molecular Immunology,2011,48(9/10):1091-1101.
[11] HAPFELMEIER S,LAWSON M A E,SLACK E,et al.Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses[J].Science,2010,328(5986):1705-1709.
[12] WANG Q,SUN Q,QI R L,et al.Effects of Lactobacillus plantarum on the intestinal morphology,intestinal barrier function and microbiota composition of suckling piglets[J].Journal of Animal Physiology and Animal Nutrition,2019,doi:10.1111/jpn.13198.
[13] KUMAR H,KAWAI T,AKIRA S.Toll-like receptors and innate immunity[J].Biochemical and Biophysical Research Communications,2009,388(4):621-625.
[14] RICHMOND B W,BRUCKER R M,HAN W,et al.Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency[J].Nature Communications,2016,7:11240.
[15] KATO-NAGAOKA N,SHIMADA S I,YAMAKAWA Y,et al.Enhanced differentiation of intraepithelial lymphocytes in the intestine of polymeric immunoglobulin receptor-deficient mice[J].Immunology,2015,146(1):59-69.
[16] DONALDSON G P,LADINSKY M S,YU K B,et al.Gut microbiota utilize immunoglobulin A for mucosal colonization[J].Science,2018,360(6390):795-800.
[17] FAGARASAN S,MURAMATSU M,SUZUKI K,et al.Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora[J].Science,2002,298(5597):1424-1427.
[18] SUZUKI K,MEEK B,DOI Y,et al.Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(7):1981-1986.
[19] VIJAY-KUMAR M,AITKEN J D,CARVALHO F A,et al.Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5[J].Science,2010,328(5975):228-231.
[20] GARRETT W S,LORD G M,PUNIT S,et al.Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system[J].Cell,2007,131(1):33-45.
[21] LEONE R D,EMENS L A.Targeting adenosine for cancer immunotherapy[J].Journal for ImmunoTherapy of Cancer,2018,6(1):57.
[22] QIN Z,WANG P Y,SU D F,et al.miRNA-124 in immune system and immune disorders[J].Frontiers in Immunology,2016,7:406.
[23] LARSSON E,TREMAROLI V,LEE Y S,et al.Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88[J].Gut,2012,61(8):1124-1131.
[24] XUE X C,FENG T,YAO S X,et al.Microbiota downregulates dendritic cell expression of miR-10a,which targets IL-12/IL-23p40[J].The Journal of Immunology,2011,187(11):5879-5886.
[25] WU W,HE C,LIU C Q,et al.miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD[J].Gut,2015,64(11):1755-1764.
[26] ZHOU R,CHANG Y,LIU J,et al.JNK pathway-associated phosphatase/DUSP22 suppresses CD4+ T-cell activation and Th1/Th17-cell differentiation and negatively correlates with clinical activity in inflammatory bowel disease[J].Frontiers in Immunology,2017,8:781.
[27] HOOPER L V,LITTMAN D R,MACPHERSON A J,et al.Interactions between the microbiota and the immune system[J].Science,2012,336(6086):1268-1273.
[28] BRUNNER P M,LEUNG D Y M,GUTTMAN-YASSKY E,et al.Immunologic,microbial,and epithelial interactions in atopic dermatitis[J].Annals of Allergy,Asthma & Immunology,2018,120(1):34-41.
[29] ARCHAMBAUD C,SISMEIRO O,TOEDLING J,et al.The intestinal microbiota interferes with the microRNA response upon oral listeria infection[J].mBio,2013,4(6):e00707-13.
[30] VIKRAM A,KIM Y R,KUMAR S,et al.Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating sirtuin1[J].Nature Communications,2016,7:12565.
[31] MCKENNA L B,SCHUG J,VOUREKAS A,et al.MicroRNAs control intestinal epithelial differentiation,architecture,and barrier function[J].Gastroenterology,2010,139(5):1654-1664.e1.
[32] NAKATA K,SUGI Y,NARABAYASHI H,et al.Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4[J].Journal of Biological Chemistry,2017,292(37):15426-15433.
[33] DUERR C U,HORNEF M W.The mammalian intestinal epithelium as integral player in the establishment and maintenance of host-microbial homeostasis[J].Seminars in Immunology,2012,24(1):25-35.
[34] SCHULTE L N,WESTERMANN A J,VOGEL J,et al.Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing[J].Nucleic Acids Research,2013,41(1):542-553.
[35] SELVAMANI S P,MISHRA R,SINGH S K,et al.Chikungunya virus exploits miR-146a to regulate NF-κB pathway in human synovial fibroblasts[J].PLoS One,2014,9(8):e103624.
[36] BILLETER A T,HELLMANN J,ROBERTS H,et al.MicroRNA-155 potentiates the inflammatory response in hypothermia by suppressing IL-10 production[J].The FASEB Journal,2014,28(12):5322-5336.
[37] KUROWSKA-STOLARSKA M,ALIVERNINI S,BALLANTINE L E,et al.MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(27):11193-11198.
[38] MU C L,YANG Y X,ZHU W Y,et al.Gut microbiota:the brain peacekeeper[J].Frontiers in Microbiology,2016,7:345.
[39] LIU S R.The development of our organ of other kinds-the gut microbiota[J].Frontiers in Microbiology,2016,7:2107.
[40] LIU S R,DA CUNHA A P,REZENDE R M,et al.The host shapes the gut microbiota via fecal microRNA[J].Cell Host & Microbe,2016,19(1):32-43.
[41] THOMAS H.Gut microbiota:host faecal miRNA regulates gut microbiota[J].Nature Reviews Gastroenterology & Hepatology,2016,13(3):122-123.
[42] RUBINSTEIN M R,WANG X W,LIU W,et al.Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its fadA adhesin[J].Cell Host & Microbe,2013,14(2):195-206.
[43] LIU S R,WEINER H L.Control of the gut microbiome by fecal microRNA[J].Microbial Cell,2016,3(4):176-177.
