[1] HABTEMARIAM S.Berberine and inflammatory bowel disease:a concise review[J].Pharmacological Research,2016,113:592-599.
[2] IMENSHAHIDI M,HOSSEINZADEH H.Berberine and barberry (
Berberis vulgaris):a clinical review[J].Phytotherapy Research,2019,33(3):504-523.
[3] 张茜,朴香淑.小檗碱抑菌作用研究进展[J].中国畜牧杂志,2010,46(3):58-61.
[4] JEONG D Y,KIM S,SON M J,et al.Induction and maintenance treatment of inflammatory bowel disease:a comprehensive review[J].Autoimmunity Reviews,2019,18(5):439-454.
[5] MALOY K J,POWRIE F.Intestinal homeostasis and its breakdown in inflammatory bowel disease[J].Nature,2011,474(7351):298-306.
[6] DE SOUZA H S P,FIOCCHI C.Immunopathogenesis of IBD:current state of the art[J].Nature Reviews Gastroenterology & Hepatology,2016,13(1):13-27.
[7] JING Y,PENG F D,SHAN Y F,et al.Berberine reduces the occurrence of neonatal necrotizing enterocolitis by reducing the inflammatory response[J].Experimental and Therapeutic Medicine,2018,16(6):5280-5285.
[8] LI Y H,XIAO H T,HU D D,et al.Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses[J].Pharmacological Research,2016,110:227-239.
[9] LI C Z,XI Y B,LI S,et al.Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation[J].Molecular Immunology,2015,67(2):444-454.
[10] CAO S Y,YE S J,WANG W W,et al.Progress in active compounds effective on ulcerative colitis from Chinese medicines[J].Chinese Journal of Natural Medicines,2019,17(2):81-102.
[11] VAN ITALLIE C M,ANDERSON J M.Architecture of tight junctions and principles of molecular composition[J].Seminars in Cell & Developmental Biology,2014,36:157-165.
[12] NING L,GUA L L,QU L L,et al.Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an
in vitro model of intestinal epithelial cells[J].European Journal of Pharmaceutical Sciences,2010,40(1):1-8.
[13] YU X T,XU Y F,HUANG Y F,et al.Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice[J].PLoS One,2018,13(3):e0194069.
[14] HE Y,YUAN X M,ZHOU G R,et al.Activation of IGF-1/IGFBP-3 signaling by berberine improves intestinal mucosal barrier of rats with acute endotoxemia[J].Fitoterapia,2018,124:200-205.
[15] GU L L,LI N,GONG J F,et al.Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia[J].The Journal of Infectious Diseases,2011,203(11):1602-1612.
[16] 韩菲菲,彭丽媛,张学斐等.肠道黏液屏障功能的研究进展[J].动物营养学报,2018,30(12):8-14.
[17] ETZOLD S,JUGE N.Structural insights into bacterial recognition of intestinal mucins[J].Current Opinion in Structural Biology,2014,28:23-31.
[18] PELASEYED T,BERGSTRÖM J H,GUSTAFSSON J K,et al.The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system[J].Immunological Reviews,2014,260(1):8-20.
[19] SHENG Y H,LOURIE R,LINDÉN S K,et al.The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis[J].Gut,2011,60(12):1661-1670.
[20] PETERSSON J,SCHREIBER O,HANSSON G C,et al.Importance and regulation of the colonic mucus barrier in a mouse model of colitis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2011,300(2):G327-G333.
[21] ZHU L,ZHANG D Y,ZHU H,et al.Berberine treatment increases
Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in
Apoe-/- mice[J].Atherosclerosis,2018,268:117-126.
[22] CǍTANǍ C S,BERINDAN-NEAGOE I,COZMA V,et al.Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease[J].World Journal of Gastroenterology,2015,21(19):5823-5830.
[23] LUO A N,LEACH S T,BARRES R,et al.The microbiota and epigenetic regulation of T helper 17/regulatory T cells:in search of a balanced immune system[J].Frontiers in Immunology,2017,8:417.
[24] CUI H T,CAI Y Z,WANG L,et al.Berberine regulates treg/th17 balance to treat ulcerative colitis through modulating the gut microbiota in the colon[J].Frontiers in Pharmacology,2018,9:571.
[25] FERNANDEZ C P,AFRIN F,FLORES R A,et al.Downregulation of inflammatory cytokines by berberine attenuates
Riemerella anatipestifer infection in ducks[J].Developmental & Comparative Immunology,2017,77:121-127.
[26] SHEN Y B,PIAO X S,KIM S W,et al.The effects of berberine on the magnitude of the acute inflammatory response induced by
Escherichia coli lipopolysaccharide in broiler chickens[J].Poultry Science,2010,89(1):13-19.
[27] ZHU L,GU P Q,SHEN H.Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats[J].International Immunopharmacology,2019,68:242-251.
[28] 张娴,张晟,何融冰,等.肠道微生物屏障功能与病原菌毒力作用[J].现代生物医学进展,2017,17(31):6186-6190.
[29] ZHANG H Y,PIAO X S,ZHANG Q,et al.The effects of
Forsythia suspensa extract and berberine on growth performance,immunity,antioxidant activities,and intestinal microbiota in broilers under high stocking density[J].Poultry Science,2013,92(8):1981-1988.
[30] LV Z,PENG G L,LIU W H,et al.Berberine blocks the relapse of
Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment[J].Antimicrobial Agents and Chemotherapy,2015,59(7):3726-3735.
[31] FAN G G,CHANG J,YIN Q Q,et al.Effects of probiotics,oligosaccharides,and berberine combinations on growth performance of pigs[J].Turkish Journal of Veterinary and Animal Sciences,2015,39(6):637-642.
[32] WANG H,GUAN L N,LI J,et al.The effects of berberine on the gut microbiota in
Apcmin/+ mice fed with a high fat diet[J].Molecules,2018,23(9):2298.
[33] LIU D,ZHANG Y Y,LIU Y H,et al.Berberine modulates gut microbiota and reduces insulin resistance via the TLR4 signaling pathway[J].Experimental and Clinical Endocrinology & Diabetes,2018,126(8):513-520.
[34] ATREYA I,ATREYA R,NEURATH M F.NF-κB in inflammatory bowel disease[J].Journal of Internal Medicine,2008,263(6):591-596.
[35] LI H M,WANG Y Y,WANG H D,et al.Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms[J].Acta Pharmacologica Sinica,2011,32(11):1364-1372.
[36] CHU M,DING R,CHU Z Y,et al.Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor[J].BMC Complementary and Alternative Medicine,2014,14:89.
[37] 邹小慧,陆付耳,舒婷婷,等.小檗碱改善肠黏膜屏障损伤及其可能机制的实验研究[J].武汉大学学报(医学版),2018,39(2):207-212,218.
[38] COSKUN M,SALEM M,PEDERSEN J,et al.Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease[J].Pharmacological Research,2013,76:1-8.
[39] ZUNDLER S,NEURATH M F.Integrating immunologic signaling networks:the JAK/STAT pathway in colitis and colitis-associated cancer[J].Vaccines,2016,4(1):5.
[40] HEEMSKERK V H,DAEMEN M A R C,BUURMAN W A.Insulin-like growth factor-1(IGF-1) and growth hormone (GH) in immunity and inflammation[J].Cytokine & Growth Factor Reviews,1999,10(1):5-14.
[41] ZHANG W,FRANKEL W L,ADAMSON W T,et al.Insulin-like growth factor-Ⅰ improves mucosal structure and function in transplanted rat small intestine[J].Transplantation,1995,59(5):755-761.
[42] ZHAO T Y,SU L P,MA C Y,et al.IGF-1 decreases portal vein endotoxin via regulating intestinal tight junctions and plays a role in attenuating portal hypertension of cirrhotic rats[J].BMC Gastroenterology,2015,15:77.
[43] TIAN F,LIU G R,LI N,et al.Insulin-like growth factor I reduces the occurrence of necrotizing enterocolitis by reducing inflammatory response and protecting intestinal mucosal barrier in neonatal rats model[J].European Review for Medical and Pharmacological Sciences,2017,21(20):4711-4719.
[44] XU W N,CHEN D H,CHEN Q Q,et al.Growth performance,innate immune responses and disease resistance of fingerling blunt snout bream,
Megalobrama amblycephala adapted to different berberine-dietary feeding modes[J].Fish & Shellfish Immunology,2017,68:458-465.
