Effects of Arginine Supplementation during Lactation Period on Liver Lipid Metabolism Function of Weaned Piglets

LIU Jun; ZHONG Zhaoxin; PENG Zhong; YU Lihuai; DONG Li

doi:10.3969/j.issn.1006-267x.2020.02.023

Chinese Journal of Animal Nutrition >

2020 , Vol. 32 >Issue 2: 674 - 681

DOI: https://doi.org/10.3969/j.issn.1006-267x.2020.02.023

SWINE NUTRITION AND FEED

Effects of Arginine Supplementation during Lactation Period on Liver Lipid Metabolism Function of Weaned Piglets

LIU Jun ,
ZHONG Zhaoxin ,
PENG Zhong ,
YU Lihuai ,
DONG Li

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College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Received date: 2019-08-20

Online published: 2020-02-21

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Abstract

The purpose of this study was to investigate the effects of arginine supplementation during the lactation period on liver lipid metabolism function of weaned piglets. Forty 7-day-old suckling piglets with similar body weight were selected in pairs and divided into control group (CON group) and arginine group (Arg group) with 20 heads in each group (half male and half female). From the 7 days of age, under the natural breastfeeding, piglets in the CON group were given 40 mL normal saline daily, and those in the Arg group were given 40 mL arginine[250 mg/(kg·d)] daily. All piglets were weaned at 21 days of age and then fed a basal diet. Every eight piglets (half male and half female) were randomly selected for slaughter sampling and taking liver on day of weaning (21 days of age) and 3 days after weaning (24 days of age), respectively. The results showed as follows:1) the body weight and liver weight of piglets after weaning for 3 days were extremely significantly lower than those of piglets at weaning day (P<0.01). Compared with the CON group, the liver index of piglets in the Arg group was extremely significantly increased after weaning for 3 days (P<0.01). 2) Compared with the CON group, the hepatocyte size was extremely significantly increased (P<0.01) and the hepatocyte area was significantly increased (P<0.05) of piglets in the Arg group. 3) Three days after weaning, the contents of liver total cholesterol (TC) and triglyceride (TG) of piglets were extremely significantly higher than those of piglets at the day of weaning (P<0.01); on the day of weaning, the high-density lipoprotein cholesterol (HDL-C) content in the liver of piglets in the Arg group was significantly higher than that in the CON group (P<0.05), and the low-density lipoprotein cholesterol (LDL-C) content in the liver of piglets in the Arg group was extremely significantly lower than in the CON group (P<0.01). 4) Compared with the CON group, the relative expression level of lipoprotein lipase (LPL) gene in the liver of piglets in the Arg group was significantly higher than that in the CON group on the day of weaning (P<0.05). It is concluded that arginine supplementation during the lactation period can promote liver development of weaned piglets, increase HDL-C content in liver, decrease LDL-C content in liver, increase the expression level of LPL gene in liver, and improve liver lipid metabolism function of weaned piglets.

Key words： arginine; piglets; liver; lipid metabolism; weaning stress

Cite this article

LIU Jun , ZHONG Zhaoxin , PENG Zhong , YU Lihuai , DONG Li . Effects of Arginine Supplementation during Lactation Period on Liver Lipid Metabolism Function of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2020 , 32(2) : 674 -681 . DOI: 10.3969/j.issn.1006-267x.2020.02.023

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