Research Advance on Lipid Metabolism Regulated by Preoxisome Proliferator-Activated Receptor Gamma Signal Pathway

  • SONG Shuzhen ,
  • WU Jianping ,
  • GAO Liangshuang ,
  • LI Hong
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  • 1. Institute of Animal&Pasture Science and Green Agriculture, Gansu Academy of Agricultural Sciences, Lanzhou 730070, China;
    2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China

Received date: 2019-09-12

  Online published: 2020-04-16

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Abstract

Preoxisome proliferator-activated receptor gamma (PPARγ) is an essential transcription factor for fat formation in the body. It is located the central position of signal transmission which regulates the genes expression relating the lipid deposition, and it not only promotes the orientation of multidirectional mesenchymal stem cells to fat cells, but also promotes the proliferation, differentiation and lipid deposition of fat cells. First, the basic structure of PPARγ and the basic characteristics of regulatory target genes were introduced. Then, the regulatory effects of PPARγ on adipocyte formation, lipid deposition and fat factor secretion were reviewed according to the adipocyte formation and fat deposition as the main lines.Finally, the feedback regulation between PPARγ and biological clock and its important role were instructed in lipid deposition, and high fat intake causes elevated transcription factor PPARγ to disrupt the normal biological clock. The review indicated that further understand the structure and function of PPARγ, the molecular mechanism of PPARγ regulation of fat metabolism, and provides target genes and new approaches for artificial intervention of fat metabolism and related diseases.

Cite this article

SONG Shuzhen , WU Jianping , GAO Liangshuang , LI Hong . Research Advance on Lipid Metabolism Regulated by Preoxisome Proliferator-Activated Receptor Gamma Signal Pathway[J]. Chinese Journal of Animal Nutrition, 2020 , 32(4) : 1473 -1483 . DOI: 10.3969/j.issn.1006-267x.2020.04.002

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