[1] IGLESIAS-FIGUEROA B F,ESPINOZA-SÁNCHEZ E A,SIQUEIROS-CENDÓN T S,et al.Lactoferrin as a nutraceutical protein from milk,an overview[J].International Dairy Journal,2019,89:37-41.
[2] FELIPE L D O,DA SILVAJÚNIOR W F,DEARAÚJO K C,et al.Lactoferrin,chitosan and
Melaleuca alternifolia-natural products that show promise in candidiasis treatment[J].Brazilian Journal of Microbiology,2018,49(2):212-219.
[3] ASSELIN-PATUREL C,BOONSTRA A,DALOD M,et al.Mouse type Ⅰ IFN-producing cells are immature APCs with plasmacytoid morphology[J].Nature Immunology,2001,2(12):1144-1150.
[4] KANWAR J R,ROY K,PATEL Y,et al.Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions[J].Molecules,2015,20(6):9703-9731.
[5] FARNAUD S,EVANS R W.Lactoferrin-a multifunctional protein with antimicrobial properties[J].Molecular Immunology,2003,40(7):395-405.
[6] KRUZEL M L,ACTOR J K,RADAK Z,et al.Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model[J].Innate Immunity,2010,16(2):67-79.
[7] EMBLETON N D,BERRINGTON J E,MCGUIRE W,et al.Lactoferrin:antimicrobial activity and therapeutic potential[J].Seminars in Fetal and Neonatal Medicine,2013,18(3):143-149.
[8] MORENO-EXPÓSITO L,ILLESCAS-MONTES R,MELGUIZO-RODRÍGUEZ L,et al.Multifunctional capacity and therapeutic potential of lactoferrin[J].Life Sciences,2018,195:61-64.
[9] SANCHEZ L,CALVO M,BROCK J H.Biological role of lactoferrin[J].Archives of Disease in Childhood,1992,67(5):657-661.
[10] BAKER E N,BAKER H M.Lactoferrin:molecular structure,binding properties and dynamics of lactoferrin[J].Cellular and Molecular Life Sciences,2005,62(22):2531-2539.
[11] MORENO-NAVARRETE J M,ORTEGA F J,BASSOLS J,et al.Decreased circulating lactoferrin in insulin resistance and altered glucose tolerance as a possible marker of neutrophil dysfunction in type 2 diabetes[J].The Journal of Clinical Endocrinology & Metabolism,2009,94(10):4036-4044.
[12] ASANUMA H,TORIGOE T,KAMIGUCHI K,et al.Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells[J].Cancer Research,2005,65(23):11018-11025.
[13] KANWAR J R,PALMANO K P,SUN X Y,et al.‘Iron-saturated’ lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapy[J].Immunology and Cell Biology,2008,86(3):277-288.
[14] AISEN P,LEIBMAN A.Lactoferrin and transferrin:comparative study[J].Biochimica et Biophysica Acta:Protein Structure,1972,257(2):314-323.
[15] GONZÁLEZ-CHÁVEZ S A,ARÉVALO-GALLEGOS S,RASCÓN-CRUZ Q.Lactoferrin:structure,function and applications[J].International Journal of Antimicrobial Agents,2009,33(4):301.e1-8.
[16] GARCÍA-MONTOYA I A,CENDÓN T S,ARÉVALO-GALLEGOS S,et al.Lactoferrin a multiple bioactive protein:an overview[J].Biochimica et Biophysica Acta:General Subjects,2012,1820(3):226-236.
[17] ZHANG J S,LAI S Y,CAI Z X,et al.Determination of bovine lactoferrin in dairy products by ultra-high performance liquid chromatography-tandem mass spectrometry based on tryptic signature peptides employing an isotope-labeled winged peptide as internal standard[J].Analytica Chimica Acta,2014,829:33-39.
[18] INDYK H E,FILONZI E L.Determination of lactoferrin in bovine milk,colostrum and infant formulas by optical biosensor analysis[J].International Dairy Journal,2005,15(5):429-438.
[19] HWANG P M,ZHOU N,SHAN X,et al.Three-dimensional solution structure of lactoferricin B,an antimicrobial peptide derived from bovine lactoferrin[J].Biochemistry,1998,37(12):4288-4298.
[20] OCHOA T J,CLEARY T G.Effect of lactoferrin on enteric pathogens[J].Biochimie,2009,91(1):30-34.
[21] SIQUEIROS-CENDÓN T,ARÉVALO-GALLEGOS S,IGLESIAS-FIGUEROA B F,et al.Immunomodulatory effects of lactoferrin[J].Acta Pharmacologica Sinica,2014,35(5):557-566.
[22] PEARL C A,ROSER J F.Lactoferrin expression and secretion in the stallion epididymis[J].Reproductive Biology,2014,14(2):148-154.
[23] LEGRAND D,MAZURIER J.A critical review of the roles of host lactoferrin in immunity[J].Biometals,2010,23(3):365-376.
[24] AKHTAR S,AL-ZAID B,EL-HASHIM A Z,et al.Impact of PAMAM delivery systems on signal transduction pathways
in vivo:modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney[J].International Journal of Pharmaceutics,2016,514(2):353-363.
[25] CHILTON C H,CROWTHER G S,ŚPIEWAK K,et al.Potential of lactoferrin to prevent antibiotic-induced
Clostridium difficile infection[J].Journal of Antimicrobial Chemotherapy,2016,71(4):975-985.
[26] GARCÍA-MONTOYA I A,CENDÓN T S,ARÉVALO-GALLEGOS S,et al.Lactoferrin a multiple bioactive protein:an overview[J].Biochimica et Biophysica Acta:General Subjects,2012,1820(3):226-236.
[27] ROSA L,CUTONE A,LEPANTO M S,et al.Lactoferrin:a natural glycoprotein involved in iron and inflammatory homeostasis[J].International Journal of Molecular Sciences,2017,18(9):E1985.
[28] REYES-CORTES R,ACOSTA-SMITH E,MONDRAGÓN-FLORES R,et al.Antibacterial and cell penetrating effects of LFcin17-30,LFampin265-284,and LF chimera on enteroaggregative
Escherichia coli[J].Biochemistry and Cell Biology,2017,95(1):76-81.
[29] 68DE FERRER A R,BARONI A,SAMBUCETTI M,et al.Lactoferrin levels in term and preterm milk[J].Journal of the American College of Nutrition,2000,19(3):370-373.
[30] WANG J,BI M X,LIU H Y,et al.The protective effect of lactoferrin on ventral mesencephalon neurons against MPP
+ is not connected with its iron binding ability[J].Scientific Reports,2015,5:10729.
[31] LEGRAND D.Overview of lactoferrin as a natural immune modulator[J].The Journal of Pediatrics,2016,173(Suppl.1):S10-S15.
[32] 解伟纯,王玉峰,皮若冰,等.表达猪乳铁蛋白肽重组屎肠球菌对断奶仔猪生长性能的影响及其抗ETEC感染效果研究[J].中国畜牧兽医,2018,45(12):3408-3418.
[33] WANG S B,DNEG Y Q,REN J,et al.Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms[J].Scandinavian Journal of Immunology,2013,78(6):507-515.
[34] NAKATSUJI T,GALLO R L.Antimicrobial peptides:old molecules with new ideas[J].Journal of Investigative Dermatology,2012,132(3):887-895.
[35] LUPETTI A,BROUWER C P J M,BOGAARDS S J P,et al.Human lactoferrin-derived peptide's antifungal activities against disseminated
Candida albicans infection[J].The Journal of Infectious Diseases,2007,196(9):1416-1424.
[36] VELLIYAGOUNDER K,ALSAEDI W,ALABDULMOHSEN W,et al.Oral lactoferrin protects against experimental candidiasis in mice[J].Journal of Applied Microbiology,2015,118(1):212-221.
[37] TANIDA T,RAO F,HAMADA T,et al.Lactoferrin peptide increases the survival of
Candida albicans-inoculated mice by upregulating neutrophil and macrophage functions,especially in combination with amphotericin B and granulocyte-macrophage colony-stimulating factor[J].Infection and Immunity,2001,69(6):3883-3890.
[38] TANIDA T,OKAMOTO T,UETA E,et al.Antimicrobial peptides enhance the candidacidal activity of antifungal drugs by promoting the efflux of ATP from
Candida cells[J].Journal of Antimicrobial Chemotherapy,2006,57(1):94-103.
[39] CARDENAS-RODRIGUEZ M,CHATZI A,TOKATLIDIS K.Iron-sulfur clusters:from metals through mitochondria biogenesis to disease[J].JBIC Journal of Biological Inorganic Chemistry,2018,23(4):509-520.
[40] VIANI R M,GUTTEBERG T,LATHEY J,et al.Lactoferrin inhibits HIV-1 replication
in vitro and exhibits synergy when combined with zidovudine[J].Aids,1999,13(10):1273-1274.
[41] WANG H X,YE X Y,NG T B.First demonstration of an inhibitory activity of milk proteins against human immunodeficiency virus-1 reverse transcriptase and the effect of succinylation[J].Life Sciences,2000,67(22):2745-2752.
[42] ANDERSEN J H,OSBAKK S A,VORLAND L H,et al.Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts[J].Antiviral Research,2001,51(2):141-149.
[43] WAKABAYASHI H,ODA H,YAMAUCHI K,et al.Lactoferrin for prevention of common viral infections[J].Journal of Infection and Chemotherapy,2014,20(11):666-671.
[44] KOZU T,IINUMA G,OHASHI Y,et al.Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized,placebo-controlled clinical trial[J].Cancer Prevention Research,2009,2(11):975-983.
[45] KUHARA T,YAMAUCHI K,TAMURA Y,et al.Oral administration of lactoferrin increases NK cell activity in mice via increased production of IL-18 and type I IFN in the small intestine[J].Journal of Interferon & Cytokine Research,2006,26(7):489-499.
[46] WAKABAYASHI H,TAKAKURA N,YAMAUCHI K,et al.Modulation of immunity-related gene expression in small intestines of mice by oral administration of lactoferrin[J].Clinical and Vaccine Immunology,2006,13(2):239-245.
[47] The ELFIN Trial Investigators Group.Enteral lactoferrin supplementation for very preterm infants:a randomised placebo-controlled trial[J].The Lancet,2019,393(10170):423-433.
[48] SORTINO O,HULLSIEK K H,RICHARDS E,et al.The effects of recombinant human lactoferrin on immune activation and the intestinal microbiome among persons living with human immunodeficiency virus and receiving antiretroviral therapy[J].The Journal of Infectious Diseases,2019,219(12):1963-1968.
[49] PUDDU P,VALENTI P,GESSANI S.Immunomodulatory effects of lactoferrin on antigen presenting cells[J].Biochimie,2009,91(1):11-18.
[50] ACTOR J K,HWANG S A,KRUZEL M L.Lactoferrin as a natural immune modulator[J].Current Pharmaceutical Design,2009,15(17):1956-1973.
[51] LIU K Y,COMSTOCK S S,SHUNK J,et al.Natural killer cell populations and cytotoxic activity in pigs fed mother's milk,formula,or formula supplemented with bovine lactoferrin[J].Pediatric Research,2013,74(4):402-407.
[52] RADHAKRISHNAN S,WIEHAGEN K R,PULKO V,et al.Induction of a Th1 response from Th2-polarized T cells by activated dendritic cells:dependence on TCR:peptide-MHC interaction,ICAM-1,IL-12,and IFN-γ[J].The Journal of Immunology,2007,178(6):3583-3592.
[53] SIQUEIROS-CENDÓN T,ARÉVALO-GALLEGOS S,IGLESIAS-FIGUEROA B F,et al.Immunomodulatory effects of lactoferrin[J].Acta Pharmacologica Sinica,2014,35(5):557-566.
[54] ARTYM J,ZIMECKI M,KRUZEL M L.Reconstitution of the cellular immune response by lactoferrin in cyclophosphamide-treated mice is correlated with renewal of T cell compartment[J].Immunobiology,2003,207(3):197-205.
[55] MACMANUS C F,COLLINS C B,NGUYEN T T,et al.VEN-120,a recombinant human lactoferrin,promotes a regulatory T Cell[Treg] phenotype and drives resolution of inflammation in distinct murine models of inflammatory bowel disease[J].Journal of Crohn's and Colitis,2017,11(9):1101-1112.
[56] FARNAUD S,EVANS R W.Lactoferrin-a multifunctional protein with antimicrobial properties[J].Molecular Immunology,2003,40(7):395-405.
[57] KUHARA T,YAMAUCHI K,TAMURA Y,et al.Oral administration of lactoferrin increases NK cell activity in mice via increased production of IL-18 and type Ⅰ IFN in the small intestine[J].Journal of Interferon & Cytokine Research,2006,26(7):489-499.
[58] SEDER R A,GAZZINELLI R,SHER A,et al.Interleukin 12 acts directly on CD4
+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming[J].Proceedings of the National Academy of Sciences of the United States of America,1993,90(21):10188-10192.
[59] ZHAO M,LI M Y,GAO X F,et al.Downregulation of BDH2 modulates iron homeostasis and promotes DNA demethylation in CD4
+ T cells of systemic lupus erythematosus[J].Clinical Immunology,2018,187:113-121.
[60] PUDDU P,VALENTI P,GESSANI S.Immunomodulatory effects of lactoferrin on antigen presenting cells[J].Biochimie,2009,91(1):11-18.
[61] MURPHY K M,REINER S L.The lineage decisions of helper T cells[J].Nature Reviews Immunology,2002,2(12):933-944.
[62] SPADARO M,CAORSI C,CERUTI P,et al.Lactoferrin,a major defense protein of innate immunity,is a novel maturation factor for human dendritic cells[J].The FASEB Journal,2008,22(8):2747-2757.
[63] SCHMITT M E,SITTE S,VOEHRINGER D.CD4 T helper cells instruct lymphopenia-induced memory-like CD8 T cells for control of acute LCMV infection[J].Frontiers in Immunology,2016,7:622.
[64] STURGE C R,BENSON A,RAETZ M,et al.TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(26):10711-10716.
[65] NIELSEN S M,HANSEN G H,DANIELSEN E M.Lactoferrin targets T cells in the small intestine[J].Journal of Gastroenterology,2010,45(11):1121-1128.
[66] SIGMUNDSDOTTIR H,BUTCHER E C.Environmental cues,dendritic cells and the programming of tissue-selective lymphocyte trafficking[J].Nature Immunology,2008,9(9):981-987.
[67] WU H J,IVANOV I I,DARCE J,et al.Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells[J].Immunity,2010,32(6):815-827.
[68] COLGAN T J,KNOBLOCH G,REEDER S B,et al.Sensitivity of quantitative relaxometry and susceptibility mapping to microscopic iron distribution[J].Magnetic Resonance in Medicine,2019,83(2):673-680.
[69] ROY K,PATEL Y S,KANWAR R K,et al.Biodegradable Eri silk nanoparticles as a delivery vehicle for bovine lactoferrin against MDA-MB-231 and MCF-7 breast cancer cells[J].International Journal of Nanomedicine,2016,11:25-44.
[70] BURROW H,KANWAR R K,KANWAR J R.Antioxidant enzyme activities of iron-saturated bovine lactoferrin (Fe-bLF) in human gut epithelial cells under oxidative stress[J].Medicinal Chemistry,2011,7(3):224-230.
[71] ASANUMA H,TORIGOE T,KAMIGUCHI K,et al.Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells[J].Cancer Research,2005,65(23):11018-11025.
[72] KHAMISIPOUR G,MANSOURABADI E,NAEIMI B,et al.Knockdown of microRNA-29a regulates the expression of apoptosis-related genes in MCF-7 breast carcinoma cells[J].Molecular and Clinical Oncology,2018,8(2):362-369.
[73] GRZYBOWSKA-IZYDORCZYK O,CEBULA B,ROBAK T,et al.Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia[J].European Journal of Cancer,2010,46(4):800-810.
[74] GIBBONS J A,KANWAR J R,KANWAR R K.Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer[J].BMC Cancer,2015,15:425.
