[1] ISAACSON R,KIM H B.The intestinal microbiome of the pig[J].Animal Health Research Reviews,2012,13(1):100-109.

[2] YATSUNENKO T,REY F E,MANARY M J,et al.Human gut microbiome viewed across age and geography[J].Nature,2012,486(7402):222-227.

[3] CALDER P C.Fatty acids and inflammation:the cutting edge between food and pharma[J].European Journal of Pharmacology,2011,668(Suppl.1):S50-S58.
[4] MARTINEZ I,WALLACE G,ZHANG C M,et al.Diet-induced metabolic improvements in a hamster model of hypercholesterolemia are strongly linked to alterations of the gut microbiota[J].Applied and Environmental Microbiology,2009,75(12):4175-4184.

[5] PRIETO I,HIDALGO M,SEGARRA A B,et al.Influence of a diet enriched with virgin olive oil or butter on mouse gut microbiota and its correlation to physiological and biochemical parameters related to metabolic syndrome[J].PLoS One,2018,13(1):e0190368.
[6] RIDAURA V K,FAITH J J,REY F E,et al. Cultured gut microbiota from twins discordant for obesity modulate adiposity and metabolic phenotypes in mice[J].Science,2013,341(6150):1241214.
[7] XIAO L,ESTELLÉ J,KIILERICH P,et al.A reference gene catalogue of the pig gut microbiome[J].Nature Microbiology,2016,1:16161.
[8] EL KAOUTARI A,ARMOUGOM F,GORDON J I,et al.The abundance and variety of carbohydrate-active enzymes in the human gut microbiota[J].Nature Reviews Microbiology,2013,11(7):497-504.

[9] PATEL D D,PATEL A K,PARMAR N R,et al.Microbial and carbohydrate active enzyme profile of buffalo rumen metagenome and their alteration in response to variation in the diet[J].Gene,2014,545(1):88-94.

[10] YAO G,WU S G,ZENG X C,et al.Different gut microbiome composition in obese
Guizhou minipigs between female and castrated male[J].Folia Microbiologica,2019.DOI:10.1007/s12223-019-00704-4.
[11] ELLEKILDE M,SELFJORD E,LARSEN C S,et al.Transfer of gut microbiota from lean and obese mice to antibiotic-treated mice[J].Scientific Reports,2014,4:5922.
[12] DUNCAN S H,LOUIS P,THOMSON J M,et al.The role of pH in determining the species composition of the human colonic microbiota[J].Environmental Microbiology,2009,11(8):2112-2122.

[13] DIAO H,JIAO A R,YU B,et al.Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets[J].Genes & Nutrition,2019,14:4.
[14] ZHANG Y N,YU K F,CHEN H Z,et al.Caecal infusion of the short-chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model[J].Microbial Biotechnology,2018,11(5):859-868.

[15] XU J M,CHEN X,YU S Q,et al.Effects of early intervention with sodium butyrate on gut microbiota and the expression of inflammatory cytokines in neonatal piglets[J].PLoS One,2016,11(9):e0162461.
[16] HUANG C,SONG P X,FAN P X,et al.Dietary sodium butyrate decreases postweaning diarrhea by modulating intestinal permeability and changing the bacterial communities in weaned piglets[J]. The Journal of Nutrition,2015,145(12):2774-2780.

[17] GÁLFI P,BOKORI J.Feeding trial in pigs with a diet containing sodium n-butyrate[J].Acta Veterinaria Hungarica,1990,38(1/2):3-17.
[18] JUNG T H,PARK J H,JEON W M,et al.Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway[J].Nutrition Research and Practice,2015,9(4):343-349.

[19] ZENTEK J,BUCHHEIT-RENKO S,FERRARA F,et al.Nutritional and physiological role of medium-chain triglycerides and medium-chain fatty acids in piglets[J].Animal Health Research Reviews,2011,12(1):83-93.

[20] HSIAO C P,SIEBERT K J.Modeling the inhibitory effects of organic acids on bacteria[J].International Journal of Food Microbiology,1999,47(3):189-201.

[21] LAN R X,KIM I.Effects of organic acid and medium chain fatty acid blends on the performance of sows and their piglets[J].Animal Science Journal,2018,89(12):1673-1679.

[22] HAN Y S,TANG C H,ZHAO Q Y,et al.Effects of dietary supplementation with combinations of organic and medium chain fatty acids as replacements for chlortetracycline on growth performance,serum immunity,and fecal microbiota of weaned piglets[J].Livestock Science,2018,216:210-218.
[23] ZENTEK J,FERRARA F,PIEPER R,et al.Effects of dietary combinations of organic acids and medium chain fatty acids on the gastrointestinal microbial ecology and bacterial metabolites in the digestive tract of weaning piglets[J]. Journal of Animal Science,2013,91(7):3200-3210.

[24] ZENTEK J,BUCHHEIT-RENKO S,MÄNNER K,et al.Intestinal concentrations of free and encapsulated dietary medium-chain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets[J].Archives of Animal Nutrition,2012,66(1):14-26.

[25] DIERICK N A,DECUYPERE J A,MOLLY K,et al.The combined use of triacylglycerols containing medium-chain fatty acids (MCFAs) and exogenous lipolytic enzymes as an alternative for nutritional antibiotics in piglet nutrition:Ⅰ.
In vitro screening of the release of MCFAs from selected fat sources by selected exogenous lipolytic enzymes under simulated pig gastric conditions and their effects on the gut flora of piglets[J].Livestock Production Science,2002,75(2):129-142.

[26] SERHAN C N.Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators[J].Prostaglandins,Leukotrienes and Essential Fatty Acids,2008,79(3/4/5):157-163.
[27] NIE Y F,HU J,YAN X H.Cross-talk between bile acids and intestinal microbiota in host metabolism and health[J].Journal of
Zhejiang University:Science B,2015,16(6):436-446.

[28] INAGAKI T,MOSCHETTA A,LEE Y K,et al.Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(10):3920-3925.

[29] LAVALLEE C M,MACPHERSON J A R,ZHOU M,et al.Lipid emulsion formulation of parenteral nutrition affects intestinal microbiota and host responses in neonatal piglets[J].Journal of Parenteral and Enteral Nutrition,2017,41(8):1301-1309.

[30] KALIANNAN K,WANG B,LI X Y,et al.A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia[J].Scientific Reports,2015,5:11276.
[31] WATSON H,MITRA S,CRODEN F C,et al.A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota[J].Gut Microbiota,2017,67(11):1974-1983.
[32] LI Q R,ZHANG Q,WANG C Y,et al.Fish oil enhances recovery of intestinal microbiota and epithelial integrity in chronic rejection of intestinal transplant[J].PLoS One,2011,6(6):e20460.
[33] HUANG E Y,LEONE V A,DEVKOTA S,et al.Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue[J].Journal of Parenteral and Enteral Nutrition,2013,37(6):746-754.

[34] REYES L M,VÁZQUEZ R G,ARROYO S M C,et al.Correlation between diet and gut bacteria in a population of young adults[J].International Journal of Food Sciences and Nutrition,2016,67(4):470-478.

[35] NAOUMOVA R P,BETTERIDGE D J.A new drug target for treatment of dyslipidaemia associated with type 2 diabetes and the metabolic syndrome?[J].The Lancet,2002,359(9325):2215-2216.

[36] BÄCKHED F,MANCHESTER J K,SEMENKOVICH C F,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(3):979-984.

[37] VELAGAPUDI V R,HEZAVEH R,REIGSTAD C S,et al.The gut microbiota modulates host energy and lipid metabolism in mice[J].The Journal of Lipid Research,2010,51(5):1101-1112.

[38] BIBBÒ S,DORE M P,CAMMAROTA G, et al.Comment on "gut microbiota as a driver of inflammation in nonalcoholic fatty liver disease"[J].Mediators of Inflammation,2018,2018:9321643.
[39] SINAL C J,TOHKIN M,MIYATA M,et al.Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis[J].Cell,2000,102(6):731-744.

[40] WATANABE M,HOUTEN S M,MATAKI C,et al.Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation[J].Nature,2006,439(7075):484-489.

[41] HENAO-MEJIA J,ELINAV E,JIN C C,et al.Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity[J].Nature,2012,482(7384):179-185.

[42] SPENCER M D,HAMP T J,REID R W,et al.Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency[J].Gastroenterology,2011,140(3):976-986.

[43] KOETH R A,WANG Z N,LEVISON B S,et al.Intestinal microbiota metabolism of
L-carnitine,a nutrient in red meat,promotes atherosclerosis[J].Nature Medicine,2013,19(5):576-585.

[44] BELLAHCENE M,O'DOWD J F,WARGENT E T,et al.Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content[J].British Journal of Nutrition,2013,109(10):1755-1764.

[45] MASLOWSKI K M,VIEIRA A T,NG A,et al.Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43[J].Nature,2009,461(7268):1282-1286.

[46] ZAIBI M S,STOCKER C J,O'DOWD J,et al.Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids[J].FEBS Letters,2010,584(11):2381-2386.

[47] BJURSELL M,ADMYRE T,GÖRANSSON M,et al.Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet[J].American Journal of Physiology.Endocrinology and Metabolism,2011,300(1):E211-E220.
[48] KIMURA I,OZAWA K,INOUE D,et al.The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43[J].Nature Communications,2013,4:1829.
[49] DUAN Y H,ZHONG Y Z,XIAO H,et al.Gut microbiota mediates the protective effects of dietary β-hydroxy-β-methylbutyrate (HMB) against obesity induced by high-fat diets[J].The Faseb Journal,2019,33(9):10019-10033.

[50] MAPHOSA Y,JIDEANI V A.Dietary fiber extraction for human nutrition-a review[J].Food Reviews International,2016,32(1):98-115.

[51] YIN J,LI Y Y,HAN H,et al.Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice[J].Journal of pineal research,2018,65(4):e12524.
[52] CANFORA E E,JOCKEN J W,BLAAK E E.Short-chain fatty acids in control of body weight and insulin sensitivity[J].Nature Reviews Endocrinology,2015,11(10):577-591.

[53] WALL R,ROSS R P,SHANAHAN F,et al.Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues[J].The American Journal of Clinical Nutrition,2009,89(5):1393-1401.

[54] KOH A,DE VADDER F,KOVATCHEVA-DATCHARY P,et al.From dietary fiber to host physiology:short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.

[55] YU H N,LI R,HUANG H Y,et al.Short-chain fatty acids enhance the lipid accumulation of 3T3-L1 cells by modulating the expression of enzymes of fatty acid metabolism[J].Lipids,2018,53(1):77-84.

[56] SINGH V,CHASSAING B,ZHANG L M,et al.Microbiota-dependent hepatic lipogenesis mediated by stearoyl CoA desaturase 1(SCD1) promotes metabolic syndrome in TLR5-deficient mice[J].Cell Metabolism,2015,22(6):983-996.

[57] KINDT A,LIEBISCH G,CLAVEL T,et al.The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice[J].Nature Communications,2018,9:3760-3775.
[58] YOSHIMOTO S,LOO T M,ATARASHI K,et al.Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome[J].Nature,2013,499(7456):97-101.