Research Advances on Lactic Acid Absorption and Transporter Carrier Protein in Rumen Epithelium

  • FAN Yaotian ,
  • XIA Guangliang ,
  • SUN Hua ,
  • WANG Hongrong
Expand
  • College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Received date: 2019-09-17

  Online published: 2020-04-16

Supported by

 

Abstract

Lactic acid is an important metabolite in the rumen. The stability of its content is essential for maintaining the normal function of the body. Rumen epithelium also plays an important role in lactic acid absorption. Therefore, this paper reviewed the lactic acid absorption from rumen epithelium and the lactic acid transporters in rumen epithelial cells to further understand the transport process of lactic acid in the rumen and the metabolism of rumen epithelium. The study of lactic acid would provide a theoretical basis.

Cite this article

FAN Yaotian , XIA Guangliang , SUN Hua , WANG Hongrong . Research Advances on Lactic Acid Absorption and Transporter Carrier Protein in Rumen Epithelium[J]. Chinese Journal of Animal Nutrition, 2020 , 32(4) : 1570 -1575 . DOI: 10.3969/j.issn.1006-267x.2020.04.014

References

[1] ENEMARK J M D,JORGENSEN R J,ST ENEMARK P.Rumen acidosis with special emphasis on diagnostic aspects of subclinical rumen acidosis:a review[J].Veterinarija ir Zootechnika,2002,20(42):16-29.
[2] OWENS F N,SECRIST D S,HILL W J,et al.Acidosis in cattle:a review[J].Journal of Animal Science,1998,76(1):275-286.  
[3] MØLLER P D,DIERNAES L,SEHESTED J,et al.Absorption and fate of L-and D-lactic acid in ruminants[J].Comparative Biochemistry and Physiology Part A:Physiology,1997,118(2):387-388.  
[4] WILLIAMS V J,MACKENZIE D D S.The absorption of lactic acid from the reticulo-rumen of the sheep[J].Australian Journal of Biological Sciences,1965,18(4):917-934.  
[5] DUNLOP R H,HAMMOND P B.D-lactic acidosis of ruminants[J].Annals of the New York Academy of Science,1965,119(3):1109-1132.
[6] HUNTINGTON G B,BRITTON R A.Effect of dietary lactic acid on rumen lactate metabolism and blood acid-base status of lambs switched from low to high concentrate diets[J].Journal of Animal Science,1979,49(6):1569-1576.  
[7] PRESTON A M,NOLLER C H.Metabolism of D-lactate by tissues of the ruminant digestive tract[J].Journal of Animal Science,1973,37(6):1403-1407.  
[8] GÁLFI P,NEOGRÁDY S,KUTAS F,et al.Keratinization of cultured ruminal epithelial cells treated with butyrate and lactate[J].Zentralblatt für Veterinärmedizin Reihe A,1983,30(10):775-781.  
[9] HALESTRAP A P,DENTON R M.Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by α-cyano-4-hydroxycinnamate (short communication)[J].Biochemical Journal,1974,138(2):313-316.
[10] KIRAT D,SALLAM K I,KATO S.Expression and cellular localization of monocarboxylate transporters (MCT2,MCT7,and MCT8) along the cattle gastrointestinal tract[J].Cell and Tissue Research,2013,352(3):585-598.  
[11] HALESTRAP A P.Monocarboxylic acid transport[J].Comperhensive Physiology,2011,3(4):1611-1643.
[12] POOLE R C,HALESTRAP A P.Transport of lactate and other monocarboxylates across mammalian plasma membranes[J].American Journal of Physiology,1993,264(1):761-782.
[13] GRAHAM C,GATHERAR I,HASLAM I,et al.Expression and localization of monocarboxylate transporters and sodium/proton exchangers in bovine rumen epithelium[J].American Journal of Physiology-Regulatory,Integrative and Comparative Physiology,2007,292(2):R997-R1007.
[14] GARCIA C K,BROWN M S,PATHAK R K,et al.cDNA cloning of MCT2,a second monocarboxylate transporter expressed in different cells than MCT1[J].Journal of Biological Chemistry,1995,270(4):1843-1849.  
[15] YOON H,FANELLI A,GROLLMAN E F,et al.Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium[J].Biochemical and Biophysical Research Communications,1997,234(1):90-94.  
[16] KIRAT D,MATSUDA Y,YAMASHIKI N,et al.Expression,cellular localization,and functional role of monocarboxylate transporter 4(MCT4) in the gastrointestinal tract of ruminants[J].Gene,2007,391(1/2):140-149.
[17] RITZHAUPT A,WOOD I S,ELLIS A,et al.Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon:its potential to transport L-lactate as well as butyrate[J].The Journal of Physiology,1998,513(3):719-732.  
[18] MVLLER F,HUBER K,PFANNKUCHE H,et al.Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2002,283(5):G1139-G1146.
[19] KIRAT D,MASUOKA J,HAYASHI H,et al.Monocarboxylate transporter 1(MCT1) plays a direct role in short-chain fatty acids absorption in caprine rumen[J].Journal of Physiology,2006,576(2):635-647.  
[20] MURAMATSU T,MIYAUCHI T.Basigin(CD147):a multifunctional transmembrane protein involved in reproduction,neural function,inflammation and tumor invasion[J].Histology & Histopathology,2003,18(3):981-987.
[21] OVENS M J,MANOHARAN C,WILSON M C,et al.The inhibition of monocarboxylate transporter 2(MCT2) by AR-C155858 is modulated by the associated ancillary protein[J].Biochemical Journal,2010,431(2):217-225.  
[22] GRAHAM C,GATHERAR I,HASLAM I,et al.Expression and localization of monocarboxylate transporters and sodium/proton exchangers in bovine rumen epithelium[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2007,292(2):R997-R1007.
[23] KOHO N,MAIJALA V,NORBERG H,et al.Expression of MCT1,MCT2 and MCT4 in the rumen,small intestine and liver of reindeer (Rangifer tarandus tarandus L.)[J].Comparative Biochemistry and Physiology Part A:Molecular & Integrative Physiology,2005,141(1):29-34.  
[24] 刘军花,朱伟云,毛胜勇.高谷物日粮促进山羊瘤胃上皮单羧酸转运蛋白1及钠钾ATP酶mRNA的表达[J].草业学报,2017,26(2):95-101.
[25] MA L,ZHAO M,ZHAO L S,et al.Effects of dietary neutral detergent fiber and starch ratio on rumen epithelial cell morphological structure and gene expression in dairy cows[J].Journal of Dairy Science,2017,100(5):3705-3712.  
[26] YAN L,ZHANG B,SHEN Z M.Dietary modulation of the expression of genes involved in short-chain fatty acid absorption in the rumen epithelium is related to short-chain fatty acid concentration and pH in the rumen of goats[J].Journal of Dairy Science,2014,97(9):5668-5675.  
[27] KIRK P,WILSON M C,HEDDLE C,et al.CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression[J].The EMBO Journal,2014,19(15):3896-3904.
[28] MIYAUCHI S,GOPAL E,FEI Y J,et al.Functional identification of SLC5A8,a tumor suppressor down-regulated in colon cancer,as a Na+-coupled transporter for short-chain fatty acids[J].Journal of Biological Chemistry,2004,279(14):13293-13296.  
[29] SRINIVAS S R,GOPAL E L,ZHUANG L N,et al.Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)[J].Biochemical Journal,2005,392(3):655-664.  
[30] 王亚洲.短链脂肪酸蓄积抑制SLC5A8和MCT1表达并加重亚急性瘤胃酸中毒[D].硕士学位论文.长春:吉林大学,2017.
Outlines

/