Effects of Glycyrrhetinic Acid on Growth Performance, Antioxidant Capacity and Reproductive Hormone Concentrations of Prepubertal Gilts

  • CHE Litao ,
  • ZHANG Chunyong ,
  • HAN Diangang ,
  • ZHONG Chonghua ,
  • LIU Shuiling ,
  • AN Qingcong ,
  • GUO Rongfu
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  • Key Laboratory of Animal Nutrition and Feed Science of Yunnan Province, Yunnan Agricultural University, Kunming 650201, China

Received date: 2019-09-23

  Online published: 2020-04-16

Supported by

 

Abstract

This experiment was conducted to investigate the effects of glycyrrhetinic acid on growth performance, antioxidant capacity and reproductive hormone concentrations of prepubertal gilts. Sixty four healthy Landrace×Yorkshire prepubertal gilts at (124±7) days of age with average body weight of (61.00±3.03) kg were randomly divided into 4 groups with 4 replicates per group and 4 gilts per replicate by similar age and body weight. The 4 groups were control group (basal diet), zearalenone group (basal diet+1 mg/kg zearalenone), glycyrrhetinic acid group (basal diet+400 mg/kg glycyrrhetinic acid) and zearalenone+glycyrrhetinic acid group (basal diet+1 mg/kg zearalenone+400 mg/kg glycyrrhetinic acid). The pretest lasted for 5 days, and the test lasted for 28 days. The results showed as follows:1) compared with control group, vulva of prepubertal gilts in zearalenone group was developed abnormal and vulva length, width and area were extremely significantly increased (P<0.01). 2) Average daily feed intake and average daily gain of prepubertal gilts in glycyrrhetinic acid and zearalenone+glycyrrhetinic acid groups were significantly higher than those in control and zearalenone groups (P<0.05). 3) Compared with control group, ether extract digestibility of prepubertal gilts in zearalenone group was significantly increased (P<0.05) and calcium and phosphorus digestibilities were significantly decreased (P<0.05), crude fiber and ether extract digestibilities in glycyrrhetinic acid group were significantly increased (P<0.05) and calcium and phosphorus digestibilities were extremely significantly increased (P<0.01), and ether extract digestibility in zearalenone+glycyrrhetinic acid group was significantly increased (P<0.05). 4) Compared with control group, serum kisspeptin (Kp), estradiol (E2) and luteinizing hormone (LH) concentrations of prepubertal gilts in zearalenone group were extremely significantly increased (P<0.01), serum Kp and E2 concentrations in glycyrrhetinic acid group were significantly increased (P<0.05), and serum Kp, E2 and LH concentrations in zearalenone+glycyrrhetinic acid group were extremely significantly increased (P<0.01). 5) Serum malondialdehyde (MDA) content of prepubertal gilts in zearalenone group was significantly higher than that in control and glycyrrhetinic acid group (P<0.05). Compared with zearalenone group, serum MDA content in zearalenone+glycyrrhetinic acid group was significantly decreased (P<0.05), and serum lactate dehydrogenase (LDH) activity was extremely significantly decreased (P<0.01). In conclusion, dietary glycyrrhetinic acid can improve growth performance and antioxidant capacity of prepubertal gilts, affect reproductive hormone concentrations, and alleviate reproductive harm of zearalenone to prepubertal gilts.

Cite this article

CHE Litao , ZHANG Chunyong , HAN Diangang , ZHONG Chonghua , LIU Shuiling , AN Qingcong , GUO Rongfu . Effects of Glycyrrhetinic Acid on Growth Performance, Antioxidant Capacity and Reproductive Hormone Concentrations of Prepubertal Gilts[J]. Chinese Journal of Animal Nutrition, 2020 , 32(4) : 1586 -1594 . DOI: 10.3969/j.issn.1006-267x.2020.04.016

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