MicroRNA Regulates Cholesterol Metabolism: a Review

  • HU Yajun ,
  • HU Yi
Expand
  • Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China

Received date: 2019-11-21

  Online published: 2020-05-15

Abstract

MicroRNA (miRNA) is a kind of short sequence RNA that does not encode protein. It plays a negative role for the target mRNA expression by pairing with complementary sequence of the target gene, and inhibits the transcription of mRNA, even degrades mRNA. Cholesterol is not only an important raw material for the synthesis of physiological active substances, but also the main component of cell membrane. Recent years, there are mounts of papers about the regulation of cholesterol metabolism by miRNA, this review focused on the regulation of animal cholesterol metabolism by miRNA.

Cite this article

HU Yajun , HU Yi . MicroRNA Regulates Cholesterol Metabolism: a Review[J]. Chinese Journal of Animal Nutrition, 2020 , 32(5) : 1965 -1972 . DOI: 10.3969/j.issn.1006-267x.2020.05.002

References

[1] BROWN M S,GOLDSTEIN J L.Sterol regulatory element binding proteins (SREBPs):controllers of lipid synthesis and cellular uptake[J].Nutrition Reviews,1998,56(Suppl.2):S1-S3.
[2] MCNAMARA D J.CHOLESTEROL|Sources,absorption,function and metabolism[M]//CABALLERO B.Encyclopedia of human nutrition.Amsterdam:Elsevier,2005,1(2005):379-385.
[3] SOBENIN I A,SALONEN J T,ZHELANKIN A V,et al.Low density lipoprotein-containing circulating immune complexes:role in atherosclerosis and diagnostic value[J].BioMed Research International,2014,2014:205697.
[4] TRAJKOVSKA K T,TOPUZOVSKA S.High-density lipoprotein metabolism and reverse cholesterol transport:strategies for raising HDL cholesterol[J].The Anatolian Journal of Cardiology,2017,18(2):149-154.
[5] AMBROS V.The functions of animal microRNAs[J].Nature,2004,431(7006):350-355.  
[6] KREK A,GRÜN D,POY M N,et al.Combinatorial microRNA target predictions[J].Nature Genetics,2005,37(5):495-500.  
[7] WANG Y C,LI Y Y,WANG X Y,et al.Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity[J].Diabetologia,2013,56(10):2275-2285.  
[8] KIM D,SUNG Y M,PARK J,et al.General rules for functional microRNA targeting[J].Nature Genetics,2016,48(12):1517-1526.  
[9] BAGGA S,BRACHT J,HUNTER S,et al.Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation[J].Cell,2005,122(4):553-563.  
[10] ROTTIERS V,NÄÄR A M.MicroRNAs in metabolism and metabolic disorders[J].Nature Reviews Molecular Cell Biology,2012,13(4):239-250.  
[11] FLOWERS E,FROELICHER E S,AOUIZERAT B E.MicroRNA regulation of lipid metabolism[J].Metabolism,2012,62(1):12-20.
[12] FILIPOWICZ W,BHATTACHARYYA S N,SONENBERG N.Mechanisms of post-transcriptional regulation by microRNAs:are the answers in sight?[J].Nature Reviews Genetics,2008,9(2):102-114.  
[13] BARTEL D P.MicroRNAs:target recognition and regulatory functions[J].Cell,2009,136(2):215-233.  
[14] DEBOSE-BOYD R A,YE J.SREBPs in lipid metabolism,insulin signaling,and beyond[J].Trends in Biochemical Sciences,2018,43(5):358-368.  
[15] BROWN M S,GOLDSTEIN J L.Cholesterol feedback:from Schoenheimer's bottle to Scap's MELADL[J].Journal of Lipid Research,2009,50(Suppl.1):S15-S27.
[16] MOHAMED A,VIVEIROS A,WILLIAMS K,et al.Aβ inhibits SREBP-2 activation through Akt inhibition[J].Journal of Lipid Research,2018,59(1):1-13.  
[17] GOEDEKE L,ROTLLAN N,CANFRÁN-DUQUE A,et al.MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels[J].Nature Medicine,2015,21(11):1280-1289.  
[18] YANG M H,LIU W D,PELLICANE C,et al.Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake[J].Journal of Lipid Research,2014,55(2):226-238.  
[19] VICKERS K C,LANDSTREET S R,LEVIN M G,et al.MicroRNA-223 coordinates cholesterol homeostasis[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(40):14518-14523.  
[20] HE M,KRATZ L E,MICHEL J J,et al.Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis,microcephaly,and developmental delay[J].Journal of Clinical Investigation,2011,121(3):976-984.  
[21] QUINTANA A M,HERNANDEZ J A,GONZALEZ C G.Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development[J].PLoS One,2017,12(7):e180856.
[22] HUANG J B,CHEN S J,CAI D L,et al.Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt/SREBP-2/HMGCR pathway[J].Life Sciences,2018,203:48-53.
[23] SUN C Z,HUANG F Z,LIU X Y,et al.miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR[J].International Journal of Molecular Medicine,2015,35(3):847-853.  
[24] SELITSKY S R,DINH T A,TOTH C L,et al.Transcriptomic analysis of chronic hepatitis B and C and liver cancer reveals microrna-mediated control of cholesterol synthesis programs[J].mBio,2015,6(6):e1500-15.
[25] ZHOU L Y,LI C C,GAO L,et al.High-density lipoprotein synthesis and metabolism (review)[J].Molecular Medicine Reports,2015,12(3):4015-4021.  
[26] GIBBONS G F,WIGGINS D,BROWN A M,et al.Synthesis and function of hepatic very-low-density lipoprotein[J].Biochemical Society Transactions,2004,32(1):59-64.  
[27] SNIDERMAN A,THOMAS D,MARPOLE D,et al.Low density lipoprotein:a metabolic pathway for return of cholesterol to the splanchnic bed[J].Journal of Clinical Investigation,1978,61(4):867-873.  
[28] RONG S X,CORTÉS V A,RASHID S,et al.Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice[J].eLife,2017,6:e25015.
[29] BOBIN-DUBIGEON C,CHAUVIN A,BRILLAUD-MEFLAH V,et al.Liver X receptor (LXR)-regulated genes of cholesterol trafficking and breast cancer severity[J].Anticancer Research,2017,37(10):5495-5498.
[30] WANG N,RANALLETTA M,MATSUURA F,et al.LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2006,26(6):1310-1316.  
[31] KENNEDY M A,BARRERA G C,NAKAMURA K,et al.ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation[J].Cell Metabolism,2005,1(2):121-131.  
[32] HOEKSTRA M,SORCI-THOMAS M.Rediscovering scavenger receptor type BⅠ:surprising new roles for the HDL receptor[J].Current Opinion in Lipidology,2017,28(3):255-260.  
[33] YANCEY P G,BORTNICK A E,KELLNER-WEIBEL G,et al.Importance of different pathways of cellular cholesterol efflux[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2003,23(5):712-719.  
[34] FOTAKIS P,KUIVENHOVEN J A,DAFNIS E,et al.The effect of natural LCAT mutations on the biogenesis of HDL[J].Biochemistry,2015,54(21):3348-3359.  
[35] HUNT J A,LU Z J.Cholesteryl ester transfer protein (CETP) inhibitors[J].Current Topics in Medicinal Chemistry,2009,9(5):419-427.  
[36] TALL A R,WANG N.Tangier disease as a test of the reverse cholesterol transport hypothesis[J].The Journal of Clinical Investigation,2000,106(10):1205-1207.  
[37] SCHMITZ G,LANGMANN T.Structure,function and regulation of the ABC1 gene product[J].Current Opinion in Lipidology,2001,12(2):129-140.  
[38] VEDHACHALAM C,DUONG P T,NICKEL M,et al.Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-Ⅰ and formation of high density lipoprotein particles[J].Journal of Biological Chemistry,2007,282(34):25123-25130.  
[39] ISHIBASHI M,MASSON D,WESTERTERP M,et al.Reduced VLDL clearance in Apoe-/-Npc1-/- mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels[J].Journal of Lipid Research,2010,51(9):2655-2663.  
[40] OKAZAKI H,GOLDSTEIN J L,BROWN M S,et al.LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size[J].Journal of Biological Chemistry,2010,285(9):6801-6810.  
[41] ZELCER N,HONG C,BOYADJIAN R,et al.LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor[J].Science,2009,325(5936):100-104.  
[42] VICKERS K C,PALMISANO B T,SHOUCRI B M,et al.MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins[J].Nature Cell Biology,2011,13(4):423-433.  
[43] JEON T I,OSBORNE T F.miRNA and cholesterol homeostasis[J].Biochimica et Biophysica Acta:Molecular and Cell Biology of Lipids,2016,1861(12):2041-2046.  
[44] DÁVALOS A,GOEDEKE L,SMIBERT P,et al.miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(22):9232-9237.  
[45] RAYNER K J,SUÁREZ Y,DÁVALOS A,et al.MiR-33 contributes to the regulation of cholesterol homeostasis[J].Science,2010,328(5985):1570-1573.  
[46] CHI W,TONG C B,GAN X N,et al.Characterization and comparative profiling of miRNA transcriptomes in bighead carp and silver carp[J].PLoS One,2011,6(8):e23549.
[47] MARQUART T J,ALLEN R M,ORY D S,et al.miR-33 links SREBP-2 induction to repression of sterol transporters[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(27):12228-12232.  
[48] GERIN I,CLERBAUX L A,HAUMONT O,et al.Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation[J].Journal of Biological Chemistry,2010,285(44):33652-33661.  
[49] NAJAFI-SHOUSHTARI S H,KRISTO F,LI Y X,et al.MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis[J].Science,2010,328(5985):1566-1569.  
[50] HORIE T,ONO K,HORIGUCHI M,et al.MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2(Srebp2) regulates HDL in vivo[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(40):17321-17326.  
[51] RAYNER K J,ESAU C C,HUSSAIN F N,et al.Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides[J].Nature,2011,478(7369):404-407.  
[52] LIU J P,TANG Y,ZHOU S F,et al.Cholesterol involvement in the pathogenesis of neurodegenerative diseases[J].Molecular and Cellular Neuroscience,2009,43(1):33-42.
[53] JEON T I,ESQUEJO R M,ROQUETA-RIVERA M,et al.An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis[J].Cell Metabolism,2013,18(1):51-61.  
[54] WU X L,YANG J H,YU L,et al.Plasma miRNA-223 correlates with risk,inflammatory markers as well as prognosis in sepsis patients[J].Medicine,2018,92(27):e11352.
[55] WAGSCHAL A,NAJAFI-SHOUSHTARI S H,WANG L F,et al.Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis[J].Nature Medicine,2015,21(11):1290-1297.  
[56] GOEDEKE L,WAGSCHAL A,FERNÁNDEZ-HERNANDO C,et al.miRNA regulation of LDL-cholesterol metabolism[J].Biochimica et Biophysica Acta:Molecular and Cell Biology of Lipids,2016,1861(12):2047-2052.  
[57] MENNIGEN J A,PANSERAT S,LARQUIER M,et al.Postprandial regulation of hepatic microRNAs predicted to target the insulin pathway in rainbow trout[J].PLoS One,2012,7(6):e38604.
[58] TSAI W C,HSU S D,HSU C S,et al.MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis[J].Journal of Clinical Investigation,2012,122(8):2884-2897.  
[59] RAMACHANDRA R K,SALEM M,GAHR S,et al.Cloning and characterization of microRNAs from rainbow trout (Oncorhynchus mykiss):their expression during early embryonic development[J].BMC Developmental Biology,2008,8:41.
[60] CHANG J H,NICOLAS E,MARKS D,et al.miR-122,a Mammalian liver-specific microRNA,is processed from hcr mRNA and maydownregulate the high affinity cationic amino acid transporter CAT-1[J].RNA Biology,2004,1(2):106-113.  
[61] CIRERA S,BIRCK M,BUSK P K,et al.Expression profiles of miRNA-122 and its target CAT1 in minipigs (Sus scrofa) fed a high-cholesterol diet[J].Comparative Medicine,2010,60(2):136-141.
[62] SOH J,IQBAL J,QUEIROZ J,et al.MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion[J].Nature Medicine,2013,19(7):892-900.  
[63] FIELDING C J,FIELDING P E.Molecular physiology of reverse cholesterol transport[J].Journal of Lipid Research,1995,36(2):211-228.
[64] CHIANG J Y L.Bile acids:regulation of synthesis[J].Journal of Lipid Research,2009,50(10):1955-1966.  
[65] CORTES V A,BUSSO D,MARDONES P,et al.Retracted:advances in the physiological and pathological implications of cholesterol[J].Biological Reviews,2013,88(4):825-843.  
[66] LI T G,FRANCL J M,BOEHME S,et al.Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice[J].Hepatology,2013,58(3):1111-1121.  
[67] TAO W J,SUN L N,SHI H J,et al.Integrated analysis of miRNA and mRNA expression profiles in tilapia gonads at an early stage of sex differentiation[J].BMC Genomics,2016,17:328.
Outlines

/