Research Progress of Oxidative Stress Damage on Livestock Tissues and Organs Associated with Antioxidative Stress Mechanism of Nuclear Factor E2 Related Factor 2-Antioxidant Response Element Signaling Pathway

ZHAO Yali; ZHANG Xinzhuang; Gerelchimeg; Manglai

doi:10.3969/j.issn.1006-267x.2020.05.013

2020 , Vol. 32 >Issue 5: 2052 - 2059

DOI: https://doi.org/10.3969/j.issn.1006-267x.2020.05.013

Research Progress of Oxidative Stress Damage on Livestock Tissues and Organs Associated with Antioxidative Stress Mechanism of Nuclear Factor E2 Related Factor 2-Antioxidant Response Element Signaling Pathway

ZHAO Yali ,
ZHANG Xinzhuang ,
Gerelchimeg ,
Manglai

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1. Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
2. Equine Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2019-10-17

Online published: 2020-05-15

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Abstract

The performance and production efficiency of livestock are improving with the development of the highly intensive and large-scale management in China. Whatever, a large amount of studies had demonstrated that oxidative stress was the rooted causes of those various kinds of stress such as weaning stress, transport stress, heat stress and cold stress, which are easier to occur in currently. Oxidative stress is harmful for the redox system of animal, leading to the damage and disease of various tissues and organs such as intestines, liver and reproductive organs. The activation of the nuclear factor E2 related factor 2(Nrf2)-antioxidant response element (ARE) signaling pathway could alleviate oxidative stress through maintaining the oxidative balance, improving the antioxidant property. The present paper summarizes the effects of oxidative stress on tissues and organs of livestock, and the antioxidative mechanism of Nrf2-ARE signaling pathway, in order to provide reference for alleviating oxidative stress damage, ensuring animal welfare and improving animal performance in livestock production.

Key words： oxidative stress; livestock production; tissue and organ damage; Nrf2-ARE signaling pathway

Cite this article

ZHAO Yali , ZHANG Xinzhuang , Gerelchimeg , Manglai . Research Progress of Oxidative Stress Damage on Livestock Tissues and Organs Associated with Antioxidative Stress Mechanism of Nuclear Factor E2 Related Factor 2-Antioxidant Response Element Signaling Pathway[J]. Chinese Journal of Animal Nutrition, 2020 , 32(5) : 2052 -2059 . DOI: 10.3969/j.issn.1006-267x.2020.05.013

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