[1] FAWLEY J,KOEHLER S,CABRERA S,et al.Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine[J].Journal of Surgical Research,2017,218:35-42.
[2] REITZ M,OGER P,MEYER A,et al.Importance of the O-antigen,core-region and lipid A of rhizobial lipopolysaccharides for the induction of systemic resistance in potato to
Globodera pallida[J].Nematology,2002,4(1):73-79.
[3] SCHROMM A B,BRANDENBURG K,LOPPNOW H,et al.Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion[J].The FEBS Journal,2000,267(7):2008-2013.
[4] TANG W H W,WANG Z N,LEVISON B S,et al.Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk[J].The New England Journal of Medicine,2013,368(17):1575-1584.
[5] PARK B S,LEE J O.Recognition of lipopolysaccharide pattern by TLR4 complexes[J].Experimental & Molecular Medicine,2013,45(12):e66.
[6] CASELLA C R,MITCHELL T C.Putting endotoxin to work for us:monophosphoryl lipid A as a safe and effective vaccine adjuvant[J].Cellular and Molecular Life Sciences,2008,65(20):3231-3240.
[7] MATA-HARO V,CEKIC C,MARTIN M,et al.The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4[J].Science,2007,316(5831):1628-1632.
[8] 贾军峰,王梦竹,崔一喆,等.脂多糖致炎时间对小鼠血液免疫与肠道组织形态的影响[J].动物营养学报,2018,30(9):3609-3616.
[9] 李先根,涂治骁,王树辉,等.亚麻籽油对脂多糖刺激断奶仔猪肠黏膜结构和免疫细胞的影响[J].动物营养学报,2018,30(2):515-523.
[10] 杨侃侃,边连全,刘显军,等.刺五加多糖对断奶仔猪生长性能、部分血液生化指标及抗氧化能力的影响[J].饲料研究,2013(3):14-17.
[11] TILG H,ZMORA N,ADOLPH T E,et al.The intestinal microbiota fuelling metabolic inflammation[J].Nature Reviews Immunology,2019:1-15,doi:10.1038/s41577-019-0198-4.
[12] DOKLADNY K,ZUHL M N,MOSELEY P L.Intestinal epithelial barrier function and tight junction proteins with heat and exercise[J].Journal of Applied Physiology,2016,120(6):692-701.
[13] 崔巍,闻颖,董亚珞,等.谷氨酰胺对体外培养肠上皮细胞屏障通透性的影响[J].世界华人消化杂志,2008,16(33):3729-3733.
[14] WU H,LUO T,LI Y M,et al.Granny Smith apple procyanidin extract upregulates tight junction protein expression and modulates oxidative stress and inflammation in lipopolysaccharide-induced Caco-2 cells[J].Food & Function,2018,9(6):3321-3329.
[15] 陈晓明.MSC及Poly(I:C)预刺激后对脓毒症大鼠肠屏障功能的保护作用及机制[D].硕士学位论文.重庆:第三军医大学,2016.
[16] YANG F J,WANG A N,ZENG X F,et al.
Lactobacillus reuteri I5007 modulates tight junction protein expression in IPEC-J2 cells with LPS stimulation and in newborn piglets under normal conditions[J].BMC Microbiology,2015,15(1):32.
[17] 刘畅.探究TLR4对小鼠肠黏膜紧密连接蛋白的调控作用[D].硕士学位论文.沈阳:中国医科大学,2018.
[18] HE C M,DENG J,HU X,et al.Vitamin a inhibits the action of LPS on the intestinal epithelial barrier function and tight junction proteins[J].Food & Function,2019,10(2):1235-1242.
[19] GUO H,CALLAWAY J B,TING P Y.Inflammasomes:mechanism of action,role in disease,and therapeutics[J].Nature Medicine,2015,21(7):677-687.
[20] KIM S J,KIM H M.Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14[J].BMB Reports,2017,50(2):55-57.
[21] GAY N J,SYMMONS M F,GANGLOFF M,et al.Assembly and localization of Toll-like receptor signalling complexes[J].Nature Reviews Immunology,2014,14(8):546-558.
[22] GUVEN-MAIOROV E,KESKIN O,GURSOY A,et al.The architecture of the TIR domain signalosome in the Toll-like receptor-4 signaling pathway[J].Scientific Reports,2015,5(1):13128.
[23] TACHADO S D,ZHANG J M,ZHU J P,et al.Pneumocystis-mediated IL-8 release by macrophages requires coexpression of mannose receptors and TLR2[J].Journal of Leukocyte Biology,2007,81(1):205-211.
[24] WESCH D,BEETZ S,OBERG H H,et al.Direct costimulatory effect of TLR3 ligand Poly(I:C) on human γδ T lymphocytes[J].The Journal of Immunology,2006,176(3):1348-1354.
[25] LU P,SODHI C P,YAMAGUCHI Y,et al.Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice[J].Mucosal immunology,2018,11(3):727-740.
[26] 罗敏,肖婷婷,曾星,等.甘草酸对LPS诱导的IEC-6细胞NF-κB通路及炎症因子表达的影响[J].中国免疫学杂志,2019,35(10):1160-1163,1168.
[27] KARIN M,CLEVERS H.Reparative inflammation takes charge of tissue regeneration[J].Nature,2016,529(7586):307-315.
[28] ATREYA I,ATREYA R,NEURATH M F.NF-κB in inflammatory bowel disease[J].Journal of Internal Medicine,2008,263(6):591-596.
[29] PARK E Y,LEE H,PARK Y J,et al.Sulglycotide ameliorates inflammation in lipopolysaccharide-stimulated mouse macrophage cells by blocking the NF-κB signaling pathway[J].Immunopharmacology and Immunotoxicology,2019,41(4):477-484.
[30] PARK B S,SONG D H,KIM H M,et al.The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex[J].Nature,2009,458(7242):1191-1195.
[31] COCHET F,PERI F.The role of carbohydrates in the lipopolysaccharide (LPS)/Toll-like receptor 4(TLR4) signalling[J].International Journal of Molecular Sciences,2017,18(11):E2318.
[32] MA L,FENG L,DING X P,et al.Effect of TLR4 on the growth of SiHa human cervical cancer cells via the MyD88-TRAF6-TAK1 and NF-κB-cyclin D1-STAT3 signaling pathways[J].Oncology Letters,2018,15(3):3965-3970.
[33] HUI B,ZHANG L P,ZHOU Q H,et al.Pristimerin Inhibits LPS-triggered neurotoxicity in BV-2 microglia cells through modulating IRAK1/TRAF6/TAK1-mediated NF-κB and AP-1 signaling pathways
in vitro[J].Neurotoxicity Research,2018,33(2):268-283.
[34] NEAL M D,LEAPHART C,LEVY R,et al.Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier[J].The Journal of Immunology,2006,176(5):3070-3079.
[35] 孙丽,夏日炜,殷学梅,等.LPS诱导条件下猪小肠上皮细胞TLR4及其信号通路基因表达变化分析[J].畜牧兽医学报,2015,46(7):1095-1101.
[36] SAKAI J,CAMMAROTA E,WRIGHT J A,et al.Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88,but TNFα expression requires TRIF and MyD88[J].Scientific Reports,2017,7(1):1428.
[37] TANIGUCHI K,KARIN M.NF-κB,inflammation,immunity and cancer:coming of age[J].Nature Reviews Immunology,2018,18(5):309-324.
[38] ZAMBRANO S,DE TOMA I,PIFFER A,et al.NF-κB oscillations translate into functionally related patterns of gene expression[J].eLife,2016(5):e09100.
[39] SUN S C.The non-canonical NF-κB pathway in immunity and inflammation[J].Nature Reviews Immunology,2017,17(9):545-558.
[40] SUN S C.The noncanonical NF-κB pathway[J].Immunological Reviews,2012,246(1):125-140.
[41] MCDANIEL D K,EDEN K,RINGEL V M,et al.Emerging roles for noncanonical NF-κB signaling in the modulation of inflammatory bowel disease pathobiology[J].Inflammatory Bowel Diseases,2016,22(9):2265-2279.
[42] LIU Z,COLPAERT S,D'HAENS G R,et al.Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production[J].The Journal of Immunology,1999,163(7):4049-4057.
