SWINE NUTRITION AND FEED

Effects of Bacillus subtilis on Growth Performance, Intestinal Morphology, Mucosal Immune and Microflora Number of Weaned Piglets

  • XING Shuaibing ,
  • CHEN Daiwen ,
  • YU Bing ,
  • LUAN Chao ,
  • HE Jun ,
  • HUANG Zhiqing ,
  • MAO Xiangbing ,
  • ZHENG Ping ,
  • LUO Junqiu ,
  • LUO Yuheng ,
  • YU Jie
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  • 1. Key Laboratory of Animal Disease-Resistance and Nutrition of Ministry of Education, Key Laboratory of Animal Disease-Resistance and Nutrition of Sichuan Province, College of Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
    2. Adisseo Life Science(Shanghai) Co., Ltd., Shanghai 201200, China

Received date: 2019-11-11

  Online published: 2020-05-15

Abstract

This experiment was conducted to investigate the effects of adding Bacillus subtilis to replace antibiotics on growth performance and intestinal health of weaned piglets. A total of 72 healthy 21-day-old DLY weaned piglets were randomly allotted 4 groups with 6 replicates per group and 3 piglets per replicate. The four groups were CON group, ANT group, ANT+BS group and BS group, respectively. The trial lasted for 49 days. The results showed as follows:1) there was no significantly difference in average daily gain (ADG) and average daily feed intake (ADFI) among groups (P>0.05); compared with the CON group, feed/gain (F/G) in ANT group was significantly decreased (P<0.05). 2) There was no significantly difference in villous height, crypt depth and villous height/crypt depth (VH/CD) of duodenum, jejunum and ileum among groups (P>0.05); compared with the CON group, the crypt depth of ileum in ANT group, ANT+BS group and BS group decreased by 10.16%, 14.98% and 18.10%, and with a tendency for significant differences (P=0.084). 3) Compared with the CON group, the number of Bifidobacteria in cecum in ANT+BS group and BS group was significantly increased (P<0.05), and there was no significantly difference compared with ANT group (P>0.05). 4) The secreted immunoglobulin A (SIgA) content in jejunum mucosa in ANT+BS group and BS group was significantly increased (P<0.05), but was significantly lower than that in ANT group(P<0.05). In summary, B. subtilis can improve the intestinal structure of weaned piglets, increase the number of beneficial bacteria in the intestinal tract, improve the immune function of intestinal mucosa, and achieve the effect of partial substitution of antibiotics, and there is no synergistic or antagonistic effect between B. subtilis and antibiotics.

Cite this article

XING Shuaibing , CHEN Daiwen , YU Bing , LUAN Chao , HE Jun , HUANG Zhiqing , MAO Xiangbing , ZHENG Ping , LUO Junqiu , LUO Yuheng , YU Jie . Effects of Bacillus subtilis on Growth Performance, Intestinal Morphology, Mucosal Immune and Microflora Number of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2020 , 32(5) : 2066 -2073 . DOI: 10.3969/j.issn.1006-267x.2020.05.015

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