[1] SALVO-ROMERO E,ALONSO-COTONER C,PARDO-CAMACHO C,et al.The intestinal barrier function and its involvement in digestive disease[J].Revista Espanola de Enfermedades Digestivas,2015,107(11):686-696.
[2] 吴姚平.肠道微生物对肠道屏障影响的初步探究[D].硕士学位论文.南昌:南昌大学,2017.
[3] 王文娟,孙冬岩,孙笑非,等.动物肠黏膜屏障与机体健康的关系探讨[J].饲料研究,2012(5):42-43,50.
[4] KU C M,LIN J Y.Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes[J].Food Chemistry,2013,141(2):1104-1113.
[5] ZERIN T,LEE M,JANG W S,et al.Anti-inflammatory potential of ursolic acid in
Mycobacterium tuberculosis-sensitized and concanavalin A-stimulated cells[J].Molecular Medicine Reports,2016,13(3):2736-2744.
[6] ACEBEY-CASTELLON I L,VOUTQUENNE-NAZABADIOKO L,MAI H D T,et al.Triterpenoid saponins from
Symplocos lancifolia[J].Journal of Natural Products,2011,74(2):163-168.
[7] OLOYEDE H O B,AJIBOYE H O,SALAWU M O,et al.Influence of oxidative stress on the antibacterial activity of betulin,betulinic acid and ursolic acid[J].Microbial Pathogenesis,2017,111:338-344.
[8] MU D W,ZHOU G B,LI J Y,et al.Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1[J].Oncology Letters,2018,15(3):3202-3206.
[9] KARAM K,SHIN E A,JUNG J H,et al.Ursolic acid induces apoptosis in colorectal cancer cells partially via upregulation of MicroRNA-4500 and inhibition of JAK2/STAT3 phosphorylation[J].International Journal of Molecular Sciences,2018,20(1):114.
[10] WANG S G,MENG X M,DONG Y Z.Ursolic acid nanoparticles inhibit cervical cancer growth
in vitro and
in vivo via apoptosis induction[J].International Journal of Oncology,2017,50(4):1330-1340.
[11] D'ABROSCA B,FIORENTINO A,MONACO P,et al.Radical-scavenging activities of new hydroxylated ursane triterpenes from cv.Annurca apples[J].Chemistry & Biodiversity,2010,2(7):953-958.
[12] LIOBIKAS J,MAJIENE D,TRUMBECKAITE S,et al.Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria[J].Journal of Natural Products,2011,74(7):1640-1644.
[13] ALI M S,IBRAHIM S A,JALIL S,et al.Ursolic acid:a potent inhibitor of superoxides produced in the cellular system[J].Phytotherapy Research,2010,21(6):558-561.
[14] 王鹏,张忠义,吴忠.熊果酸在药用植物中的分布及药理作用[J].中药材,2000(11):717-722.
[15] 马爱国,戈娜,梁惠.植物萜类化合物研究进展[C]//中国营养学研究发展报告研讨会论文集.北京:中国营养学会,2014.
[16] 梁劲康,吴志玲,吴广辉,等.氟苯尼考增溶方法的研究进展[J].中国兽药杂志,2018,52(1):69-76.
[17] DOKANIA S,JOSHI A K.Self-microemulsifying drug delivery system (SMEDDS)-challenges and road ahead[J].Drug Delivery,2015,22(6):675-690.
[18] 钦富华,林杭娟,高建青.熊果酸自微乳的制备及其大鼠在体肠吸收动力学研究[J].中药材,2012,35(12):2000-2003.
[19] 李雯,阎昭,张洁,等.熊果酸磷脂纳米注射剂在小鼠体内的分布研究[J].天津医药,2008,36(10):802-804.
[20] 程晓华,熊玉卿.Caco-2细胞单层模型中熊果酸摄取转运机制的研究[J].中草药,2009,40(12):1935-1939.
[21] ZHANG C X,MA W J,LIU D L,et al.Biotransformation of ursolic acid by
Alternaria longipes AS3.2875[J].Natural Product Research,2018,32(5):536-543.
[22] ZHANG WANG Z,GAN D K,JIAN J,et al.Protective effect of ursolic acid on the intestinal mucosal barrier in a rat model of liver fibrosis[J].Frontiers in Physiology,2019,10:956.
[23] LIU B,PIAO X,GUO L,et al.Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice[J].Molecular Medicine Reports,2016,13(6):4779.
[24] WAN S Z,LIU C,HUANG C K,et al.Ursolic acid improves intestinal damage and bacterial dysbiosis in liver fibrosis mice[J].Frontiers in Pharmacology,2019,10:1321.
[25] YOU H J,CHOI C Y,KIM J Y,et al.Ursolic acid enhances nitric oxide and tumor necrosis factor-α production via nuclear factor-κB activation in the resting macrophages[J].FEBS Letters,2001,509(2):156-160.
[26] VICENTE Y,DA ROCHA C,YU J K,et al.Architecture and function of the gastroesophageal barrier in the piglet[J].Digestive Diseases and Sciences,2001,46(9):1899-1908.
[27] RAMANAN D,CADWELL K.Intrinsic defense mechanisms of the intestinal epithelium[J].Cell Host & Microbe,2016,19(4):434-441.
[28] LO S H,LI Y X,CHENG K C,et al.Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats[J].Naunyn-Schmiedeberg's Archives of Pharmacology,2017,390(11):1097-1104.
[29] LADURNER A,ZEHL M,GRIENKE U,et al.Allspice and clove as source of triterpene acids activating the g protein-coupled bile acid receptor TGR5[J].Frontiers in Pharmacology,2017,8:468.
[30] CVIJIC M E,SUM C S S,ALT A,et al.GPCR profiling:from hits to leads and from genotype to phenotype[J].Drug Discovery Today:Technologies,2015,18:30-37.
[31] KIDA T,TSUBOSAKA Y,HORI M,et al.Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2013,33(7):1663-1669.
[32] 周娟娟,何文华,甘达凯,等.熊果酸对TGF-β1诱导肝细胞凋亡的抑制作用及其机制[J].解放军医学杂志,2017,42(5):383-388.
[33] CAMARA-LEMARROY C R,METZ L,MEDDINGS J B,et al.The intestinal barrier in multiple sclerosis:implications for pathophysiology and therapeutics[J].Brain,2018,141(7):1900-1916.
[34] 张明发,沈雅琴.熊果酸和齐墩果酸抗肝脂肪变和纤维化作用研究进展[J].药物评价研究,2017,40(2):270-278.
[35] 张梦军,孙克峰,李振翮,等.熊果酸口服治疗药物性肝损伤临床效果观察及机制探讨[J].山东医药,2019,59(7):77-79.
[36] 陆伦根,胡江峰.肠道菌群与胆汁酸的研究进展[J].内科理论与实践,2018,13(6):329-333.
[37] 张心悦,王怡仲.肠道菌群与胆汁酸关系研究进展[J].国际儿科学杂志,2018,45(9):693-697.
[38] 熊筱娟,陈蔚云,崔江龙,等.乌索酸对大鼠胆汁的影响[J].中医药学报,2003,31(4):54-55.
[39] ANDERSSON D,NILSSON A,DUAN R D.Ursolic acid and other pentacyclic triterpenoids stimulate intestinal alkaline sphingomyelinase
in vitro[J].European Journal of Lipid Science and Technology,2006,108(2):103-108.
[40] DUAN R D,NILSSON Å.Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development[J].Progress in Lipid Research,2009,48(1):62-72.
[41] NILSSON Å,DUAN R D.Absorption and lipoprotein transport of sphingomyelin[J].Journal of Lipid Research,2006,47(1):154-171.
[42] KEUNE W J,HAUSMANN J,BOLIER R,et al.Steroid binding to autotaxin links bile salts and lysophosphatidic acid signalling[J].Nature Communications,2016,7:11248.
[43] JANDHYALA S M,TALUKDAR R,SUBRAMANYAM C,et al.Role of the normal gut microbiota[J].World Journal of Gastroenterology,2015,21(29):8787-8803.
[44] 马浩然,贾海莲,张文龙,等.熊果酸对酒精性肝损伤大鼠肠道菌群的影响[J].食品科学,2018,39(11):146-151.
[45] TONG J,WANG Y,CHANG B,et al.Evidence for the involvement of rhoa signaling in the ethanol-induced increase in intestinal epithelial barrier permeability[J].International Journal of Molecular Sciences,2013,14(2):3946-3960.
[46] WO?NIAK L,SKAPSKA S,MARSZALEK K.Ursolic acid-a pentacyclic triterpenoid with a wide spectrum of pharmacological activities[J].Molecules,2015,20(11):20614-20641.
[47] DO NASCIMENTO P,LEMOS T L,BIZERRA A M,et al.Antibacterial and antioxidant activities of ursolic acid and derivatives[J].Molecules,2014,19(1):1317-1327.
[48] KUREK A,GRUDNIAK A M,SZWED M,et al.Oleanolic acid and ursolic acid affect peptidoglycan metabolism in
Listeria monocytogenes[J].Antonie van Leeuwenhoek,2010,97(1):61-68.
[49] PARK S N,AHN S J,KOOK J K.Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159[J].Brazilian Journal of Microbiology,2015,46(2):613-617.
[50] WANG C M,JHAN Y L,TSAI S J,et al.The pleiotropic antibacterial mechanisms of ursolic acid against methicillin-resistant
Staphylococcus aureus (MRSA)[J].Molecules,2016,21(7):884.
[51] PETERSON L W,ARTIS D.Intestinal epithelial cells:regulators of barrier function and immune homeostasis[J].Nature Reviews Immunology,2014,14(3):141-153.
[52] NIJKAMP F P,FOLKERTS G.Nitric oxide:initiator and modulator[J].Clinical & Experimental Allergy,2010,27(4):347-350.
[53] FARIAS-EISNER R,SHERMAN M P,AEBERHARD E,et al.Nitric oxide is an important mediator for tumoricidal activity
in vivo[J].Proceedings of the National Academy of Sciences of the United States of America,1994,91(20):9407-9411.
[54] CHUN J,LEE C,HWANG S W,et al.Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages,and attenuates experimental colitis in mice[J].Life Sciences,2014,110(1):23-34.
[55] ATREYA I,ATREYA R,NEURATH M F.NF-κB in inflammatory bowel disease[J].Journal of Internal Medicine,2008,263(6):591-596.
[56] NEURATH M F,PETTERSSON S,MEYER Z,et al.Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice[J].Nature Medicine,1996,2(9):998-1004.
[57] ROGLER G,BRAND K,VOGL D,et al.Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa[J].Gastroenterology,1998,115(2):357-369.
[58] 徐胜,黄顺荣.肠黏膜屏障损伤与保护分子机制研究进展[J].中华结直肠疾病电子杂志,2018,7(3):276-280.
[59] JANG S E,JU J J,HYAM S R,et al.Ursolic acid isolated from the seed of
Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages[J].Journal of Agricultural and Food Chemistry,2014,62(40):9711-9721.
[60] TOHMÉ M J,GIMÉNEZ M C,PERALTA A,et al.Ursolic acid:a novel antiviral compound inhibiting rotavirus infection
in vitro[J].International Journal of Antimicrobial Agents,2019,54(5):601-609.
