Research Advances on Pathogenic Mechanism and Control Measures of Trichothecenes Mycotoxin

  • YAN Zhaoming ,
  • LI Wenrui ,
  • LIU Shuangli ,
  • CHEN Qinghua
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  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. School of Urban Economics and Public Administration, Capital University of Economics and Business, Beijing 100070, China

Received date: 2019-12-06

  Online published: 2020-06-16

Abstract

Mycotoxins are secondary metabolites of molds in the process of growth and reproduction. They are characterized by a wide variety and exhibit the characteristics of "multi-bacteria production and multi-biological toxicity". Once the animals have taken the feed contaminated with mycotoxins, they will cause different degrees of damage to the body due to the different intakes, which are collectively referred to as mycotoxin poisoning. The accumulation and residue of mycotoxins in animal products can also cause great damage to human health after entering the human body. Trichothecenes are dangerous substances recognized by the World Health Organization, and the mechanism by which they cause animal poisoning has not been fully elucidated. At present, the treatment of mycotoxins is being transformed from the traditional physicochemical method to the biological detoxification. In this paper, the poisoning mechanism of trichothecenes is summarized and various detoxification methods of mycotoxins are reviewed. The aim is to provide theoretical support and basis for the development and production of mycotoxins.

Cite this article

YAN Zhaoming , LI Wenrui , LIU Shuangli , CHEN Qinghua . Research Advances on Pathogenic Mechanism and Control Measures of Trichothecenes Mycotoxin[J]. Chinese Journal of Animal Nutrition, 2020 , 32(6) : 2543 -2550 . DOI: 10.3969/j.issn.1006-267x.2020.06.013

References

[1] SNYDER A B,WOROBO R W.Risk mitigation for immunocompromised consumers of mucormycete spoiled and fermented foods:germane guidance and remaining needs[J].Microorganisms,2018,6(2):45.
[2] PALENCIA E R,HINTON D M,BACON C W.The black Aspergillus species of maize and peanuts and their potential for mycotoxin production[J].Toxins,2010,2(4):399-416.  
[3] WILD C P,GONG Y Y.Mycotoxins and human disease:a largely ignored global health issue[J].Carcinogenesis,2010,31(1):71-82.  
[4] JARVIS B B.Chemistry and toxicology of molds isolated from water-damaged buildings[M]//DEVRIES J W,TRUCKSESS M W,JACKSON L S.Mycotoxins and food safety.Boston,MA:Springer,2002,504:43-52.
[5] GRENIER B,BRACARENSE A P,LESLIE J F,et al.Physical and chemical methods for mycotoxin decontamination in maize[M]//LESLIE J F,LOGRIECO A F.Mycotoxin reduction in grain chains.New Delhi:Wiley Blackwell,2014.
[6] AWAD W A,GHAREEB K,BÖHM J,et al.Decontamination and detoxification strategies for the Fusarium mycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation[J].Food Additives & Contaminants:Part A,2010,27(4):510-520.  
[7] SCHMEITZL C,VARGA E,WARTH B,et al.Identification and characterization of carboxylesterases from Brachypodium distachyon deacetylating trichothecene mycotoxins[J].Toxins,2015,8(1):6.
[8] MENEELY J P,RICCI F,VAN EGMOND H P,et al.Current methods of analysis for the determination of trichothecene mycotoxins in food[J].TrAC Trends in Analytical Chemistry,2011,30(2):192-203.  
[9] KLÖTZEL M,LAUBER U,HUMPF H U.A new solid phase extraction clean-up method for the determination of 12 type A and B trichothecenes in cereals and cereal-based food by LC-MS/MS[J].Molecular Nutrition & Food Research,2010,50(3):261-269.
[10] GRENIER B,OSWALD I.Mycotoxin co-contamination of food and feed:meta-analysis of publications describing toxicological interactions[J].World Mycotoxin Journal,2011,4(3):285-313.  
[11] HE Y Y,LUO Q H,GE P H,et al.Review on mould contamination and hygrothermal effect in indoor environment[J].Journal of Environmental Protection,2018,9(2):100-110.  
[12] JANSSEN E M,LIU C,VAN DER FELS-KLERX H J.Fusarium infection and trichothecenes in barley and its comparison with wheat[J].World Mycotoxin Journal,2018,11(1):33-46.  
[13] KIRAN S,SUREKHA M,REDDY S M S.Influence of water activity (aw) on mould infestation and mycotoxin contamination of rice fodder[J].Asian Journal of Biological Sciences,2019,12(4):797-803.  
[14] MAEDA K,TANAKA A,SUGIURA R,et al.Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes:evolution of alternative pathways in the nivalenol chemotype[J].Environmental Microbiology,2016,18(11):3798-3811.  
[15] TORP M,LANGSETH W.Production of T-2 toxin by a Fusarium resembling Fusarium poae[J].Mycopathologia,1999,147(2):89-96.  
[16] WU W D,ZHOU H R,BURSIAN S J,et al.Emetic responses to T-2 toxin,HT-2 toxin and emetine correspond to plasma elevations of peptide YY3-36 and 5-hydroxytryptamine[J].Archives of Toxicology,2016,90(4):997-1007.  
[17] SOKOLOVI? M,GARAJ-VRHOVAC V,ŠIMPRAGA B.T-2 toxin:incidence and toxicity in poultry[J].Archives of Industrial Hygiene and Toxicology,2008,59(1):43-52.  
[18] KUCA K,DOHNAL V,JEZKOVA A,et al.Metabolic pathways of T-2 toxin[J].Current Drug Metabolism,2008,9(1):77-82.  
[19] KAPETANOV M,POTKONJAK D,STOJANOV I,et al.Importance of clinical and pathological diagnostics of mycotoxicosis in fat tening turkeys caused by T-2 trichothecene[C]//Ⅹ Ⅴ International Feed Technology Symposium "feed-to-food".Cost feed for Health Joint Workshop.Novi Sad,Serbia,2012.
[20] SEHATA S,KIYOSAWA N,ATSUMI F,et al.Microarray analysis of T-2 toxin-induced liver,placenta and fetal liver lesions in pregnant rats[J].Experimental and Toxicologic Pathology,2005,57(1):15-28.  
[21] ATROSHI F,RIZZO A,SANKARI S,et al.Liver enzyme activities of rats exposed to ochratoxin A and T-2 toxin with antioxidants[J].Bulletin of Environmental Contamination and Toxicology,2000,64(4):586-592.  
[22] WU J,JING L,YUAN H,et al.T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway[J].Toxicology Letters,2011,202(3):168-177.  
[23] CHAUDHARY M,RAO P V L.Brain oxidative stress after dermal and subcutaneous exposure of T-2 toxin in mice[J].Food and Chemical Toxicology,2010,48(12):3436-3442.  
[24] DOI K,ISHIGAMI N,SEHATA S.T-2 toxin-induced toxicity in pregnant mice and rats[J].International Journal of Molecular Sciences,2008,9(11):2146-2158.  
[25] GUO P,LIU A M,HUANG D Y,et al.Brain damage and neurological symptoms induced by T-2 toxin in rat brain[J].Toxicology Letters,2018,286:96-107.
[26] DAI C S,XIAO X L,SUN F F,et al.T-2 toxin neurotoxicity:role of oxidative stress and mitochondrial dysfunction[J].Archives of Toxicology,2019,93(11):3041-3056.  
[27] 杨凌宸.T-2/HT-2毒素对肉鸡毒性机理及其减控作用研究[D].博士学位论文.南京:南京农业大学,2015.
[28] HJELKREM A G R,AAMOT H U,BRODAL G,et al.HT-2 and T-2 toxins in Norwegian oat grains related to weather conditions at different growth stages[J].European Journal of Plant Pathology,2018,151(4):501-514.
[29] 林妮妮.基于肝微粒体的T-2毒素体外代谢研究[D].博士学位论文.北京:中国人民解放军军事医学科学院,2013.
[30] RICHARD J L.Some major mycotoxins and their mycotoxicoses-an overview[J].International Journal of Food Microbiology,2007,119(1/2):3-10.
[31] YU Y H,HSIAO F S H,PROSKURA W S,et al.An impact of deoxynivalenol produced by Fusarium graminearum on broiler chickens[J].Journal of Animal Physiology and Animal Nutrition,2018,102(4):1012-1019.  
[32] TURAY S A,LIANG S,ZHANG M I N,et al.Wrong perception and scanty knowledge on food handling:a recipe for food contamination and poisoning[J].International Journal For Research in Health Sciences and Nursing,2017,3(12):29-50.
[33] WU W D,BATES M A,BURSIAN S J,et al.Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin)[J].Toxicological Sciences,2013,133(1):186-195.  
[34] PESTKA J J.Deoxynivalenol:toxicity,mechanisms and animal health risks[J].Animal Feed Science and Technology,2007,137(3/4):283-298.
[35] WA?KIEWICZ A,BESZTERDA M,KOSTECKI M,et al.Deoxynivalenol in the gastrointestinal tract of immature gilts under per os toxin application[J].Toxins,2014,6(3):973-987.  
[36] AWAD W A,VAHJEN W,ASCHENBACH J R,et al.A diet naturally contaminated with the Fusarium mycotoxin deoxynivalenol (DON) downregulates gene expression of glucose transporters in the intestine of broiler chickens[J].Livestock Science,2011,140(1/2/3):72-79.
[37] WACHÉ Y J,VALAT C,POSTOLLEC G,et al.Impact of deoxynivalenol on the intestinal microflora of pigs[J].International Journal of Molecular Sciences,2008,10(1):1-17.  
[38] VN DE WALLE J,SERGENT T,PIRONT N,et al.Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis[J].Toxicology and Applied Pharmacology,2010,245(3):291-298.  
[39] AWAD W A,GHAREEB K,DADAK A,et al.Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds[J].Poultry Science,2012,91(3):550-555,doi:10.3382/ps.2011-01742.
[40] CHANG C,WANG K,ZHOU S N,et al.Protective effect of Saccharomyces boulardii on deoxynivalenol-induced injury of porcine macrophage via attenuating p38 MAPK signal pathway[J].Applied Biochemistry and Biotechnology,2017,182(1):411-427.  
[41] 张晓莉.脱氧雪腐镰刀菌烯醇产毒菌的筛选及产毒分子机制探究[D].硕士学位论文.南京:江苏大学,2016.
[42] KARLOVSKY P,SUMAN M,BERTHILLER F,et al.Impact of food processing and detoxification treatments on mycotoxin contamination[J].Mycotoxin Research,2016,32(4):179-205.  
[43] CHOUDHARY A K,KUMARI P,MEGHVANSI M K.Management of mycotoxin contamination in pre-harvest and post-harvest crops:present status and future prospects[J].Journal of Phytology,2010,2(7):37-52.
[44] ZHOU H T.Mixture of palygorskite and montmorillonite (Paly-Mont) and its adsorptive application for mycotoxins[J].Applied Clay Science,2016,131:140-143.
[45] 张伟.霉菌毒素吸附剂的种类和特点[J].饲料与畜牧,2018(6):71-73.
[46] 姚丽欣.霉菌毒素对饲料原料的危害以及酵母细胞壁脱霉菌毒素的研究应用[J].饲料广角,2011(1):24-27.
[47] VAN LE THANH B,LESSARD M,CHORFI Y,et al.The efficacy of anti-mycotoxin feed additives in preventing the adverse effects of wheat naturally contaminated with Fusarium mycotoxins on performance,intestinal barrier function and nutrient digestibility and retention in weanling pigs[J].Canadian Journal of Animal Science,2015,95(2):197-209.  
[48] PARK D L,LEE L S,PRICE R L,et al.Review of the decontamination of aflatoxins by ammoniation:current status and regulation.[J].Journal-Association of Official Analytical Chemists,1988,71(4):685-703.
[49] KARACA H,VELIOGLU Y S,NAS S.Mycotoxins:contamination of dried fruits and degradation by ozone[J].Toxin Reviews,2010,29(2):51-59.  
[50] 张立阳,赵雪娇,刘帅,等.食品及饲料中黄曲霉毒素生物脱毒的研究进展[J].动物营养学报,2019,31(2):521-529.
[51] 闫昭明,陈清华,陈凤鸣.玉米赤霉烯酮毒性研究[J].动物营养学报,2018,30(9):3453-3458.
[52] KARLOVSKY P.Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives[J].Applied Microbiology and Biotechnology,2011,91(3):491-504.  
[53] YU H,ZHOU T,GONG J H,et al.Isolation of deoxynivalenol-transforming bacteria from the chicken intestines using the approach of PCR-DGGE guided microbial selection[J].BMC microbiology,2010,10:182-186.
[54] ALBERTS J F,ENGELBRECHT Y,STEYN P S,et al.Biological degradation of aflatoxin B1 by Rhodococcus erythropolis cultures[J].International Journal of Food Microbiology,2006,109(1/2):121-126.
[55] 计成.饲料中霉菌毒素生物降解的研究进展[J].中国农业科学,2012,45(1):153-158.
[56] 计成,贾如,赵丽红.基因工程技术在黄曲霉毒素生物降解中的应用[J].中国农业科学,2017,50(17):3422-3428.
[57] HE W J,ZHANG L M,YI S Y,et al.An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain[J].Scientific Reports,2017,7:9549.
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