Research Progress in Urease Inhibitors and Its Mechanism

  • ZHANG Zhenyu ,
  • ZHAO Shengguo ,
  • ZHENG Nan ,
  • WANG Jiaqi
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  • 1. State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Key Laboratory of Quality and Safety Control for Milk and Dairy Products, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2020-01-09

  Online published: 2020-08-13

Abstract

Urease inhibitors suppress urease activity, consequently lower the rate of ureolytic process between the urease producing bacteria and urea. Urease inhibitor has been widely implemented in both agriculture and medical area. But the existing bacterial urease inhibitor holds a lot of downsides such as toxicity, microbial adaptation, and compromised stability. These problems limit the application of urease inhibitors. In recent years, a lot of novel urease inhibitors have been found and its motifs and substructures bearing urease inhibition capacity have been revealed. The related interaction mode and mechanism have also been demonstrated. This article reviews urease inhibitors reported in the past ten years; arranges them in different groups and discusses the structure-activity relationship, inhibition effectiveness, and inhibition mode of individual groups. The inhibition mechanism was discussed from the perspective of structure-activity relationship of different types of urease inhibitors. This article may serve as useful reference for future discovery of novel urease inhibitor.

Cite this article

ZHANG Zhenyu , ZHAO Shengguo , ZHENG Nan , WANG Jiaqi . Research Progress in Urease Inhibitors and Its Mechanism[J]. Chinese Journal of Animal Nutrition, 2020 , 32(8) : 3496 -3508 . DOI: 10.3969/j.issn.1006-267x.2020.08.007

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