Effects of Diet Composition and Antibiotics on Growth Performance and Intestinal Health of Weaned Piglets

XIA Zou; FENG Jiangxin; JIANG Junjie; CHEN Daiwen; YU Bing; HE Jun; YU Jie; MAO Xiangbing; LUO Yuheng; HUANG Zhiqing; LUO Junqiu; YAN Hui; ZHENG Ping

doi:10.3969/j.issn.1006-267x.2020.08.018

Chinese Journal of Animal Nutrition >

2020 , Vol. 32 >Issue 8: 3594 - 3604

DOI: https://doi.org/10.3969/j.issn.1006-267x.2020.08.018

Effects of Diet Composition and Antibiotics on Growth Performance and Intestinal Health of Weaned Piglets

XIA Zou ,
FENG Jiangxin ,
JIANG Junjie ,
CHEN Daiwen ,
YU Bing ,
HE Jun ,
YU Jie ,
MAO Xiangbing ,
LUO Yuheng ,
HUANG Zhiqing ,
LUO Junqiu ,
YAN Hui ,
ZHENG Ping

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Key Lab for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, China

Received date: 2020-03-05

Online published: 2020-08-13

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Abstract

This experiment was conducted to study the effects of diet composition and antibiotics on growth performance and intestinal health in weaned piglets. A total of 72 piglets (Duroc×Landrace×Yorkshire) were selected and assigned to the 4 treatments with 6 replicates per treatment and 3 weaned piglets per replicate. The trial was designed with 2×2 factors, including two diets "simple diets and complex diets" with or without antibiotics (75 mg/kg chlortetracycline and 50 mg/kg kitasamycin). The experiment lasted for 21 days. The results showed as follows:1) compared with simple diets, complex diets significantly decreased the feed/gain (F/G) and diarrhea rate of piglets from days 1 to 7 and 1 to 21(P<0.05), significantly increased the average daily gain (ADG) of piglets from days 1 to 7 (P<0.05), significantly increased the ratio of villus height to crypt depth in ileum and the number of goblet cells in jejunum (P<0.05), upregulated the relative expression of occludin (OCLN) mRNA in jejunum (P<0.05), significantly increased the contents of interleukin-10 (IL-10) (P<0.05) and transforming growth factor-β1 (TGF-β1) in jejunum, and significantly decreased the contents of interleukin-1β (IL-1β) in ileum (P<0.05). 2) Compared with no antibiotic diet, antibiotic diet significantly increased the ADG of piglets from days 1 to 7 and days 1 to 21 (P<0.05), the average daily feed intake (ADFI) from days 1 to 21 and final body weight on day 22 (P<0.05), significantly decreased the F/G and the diarrhea rate of piglets from days 1 to 7 and days 1 to 21 (P<0.05), significantly increased the ratio of villus height to crypt depth in ileum (P<0.05), significantly increased the number of goblet cells in jejunum and ileum (P<0.05), and significantly decreased the relative expressions of TLR2 mRNA in jejunum and ileum (P<0.05). In conclusion, complex diets can increase the growth performance of weaned piglets, decrease the diarrhea rate, and enhance the intestinal immune barrier function; while antibiotics can inhibit diarrhea, but has an adverse effect on intestinal barrier function of weaned piglets.

Key words： diet composition; antibiotic; weaned piglets; growth performance; intestinal health

Cite this article

XIA Zou , FENG Jiangxin , JIANG Junjie , CHEN Daiwen , YU Bing , HE Jun , YU Jie , MAO Xiangbing , LUO Yuheng , HUANG Zhiqing , LUO Junqiu , YAN Hui , ZHENG Ping . Effects of Diet Composition and Antibiotics on Growth Performance and Intestinal Health of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2020 , 32(8) : 3594 -3604 . DOI: 10.3969/j.issn.1006-267x.2020.08.018

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