[1] 张维佳,李颖,WU L F.细菌鞭毛推进器复杂的蛋白组成和精致的空间结构[J].科学通报,2014,59(20):1912-1918.
[2] MOHARI B,THOMPSON M A,TRINIDAD J C,et al.Multiple flagellin proteins have distinct and synergistic roles in
Agrobacterium tumefaciens motility[J].Journal of Bacteriology,2018,200(23):e00327-18.
[3] 刘明月,程古月,王旭,等.空肠弯曲杆菌鞭毛的研究进展[J].中国畜牧兽医,2018,45(9):2591-2599.
[4] CHASSAING B,LEY R E,GEWIRTZ A T.Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice[J].Gastroenterology,2014,147(6):1363-1377.e17.
[5] SONG W S,YOON S I.Crystal structure of FliC flagellin from
Pseudomonas aeruginosa and its implication in TLR5 binding and formation of the flagellar filament[J].Biochemical and Biophysical Research Communications,2014,444(2):109-115.
[6] SONG W S,JEON Y J,NAMGUNG B,et al.A conserved TLR5 binding and activation hot spot on flagellin[J].Scientific Reports,2017,7:40878.
[7] YOON S I,KURNASOV O,NATARAJAN V,et al.Structural basis of TLR5-flagellin recognition and signaling[J].Science,2012,335(6070):859-864.
[8] LU J H,SUN P D.The structure of the TLR5-flagellin complex:a new mode of pathogen detection,conserved receptor dimerization for signaling[J].Science Signaling,2012,5(223):pe11.
[9] IVICAK-KOCJAN K,FORSTNERIC V,PANTER G,et al.Extension and refinement of the recognition motif for Toll-like receptor 5 activation by flagellin[J].Journal of Leukocyte Biology,2018,104(4):767-776.
[10] FORSTNERI? V,IVI?AK-KOCJAN K,PLAPER T,et al.The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5[J].PLoS Pathogens,2017,13(8):e1006574.
[11] FRIEDLANDER R S,VLAMAKIS H,KIM P,et al.Bacterial flagella explore microscale hummocks and hollows to increase adhesion[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(14):5624-5629.
[12] IIDA Y,HOBLEY L,LAMBERT C,et al.Roles of multiple flagellins in flagellar formation and flagellar growth post bdelloplast lysis in
Bdellovibrio bacteriovorus[J].Journal of Molecular Biology,2009,394(5):1011-1021.
[13] MCGEE K,HÖRSTEDT P,MILTON D L.Identification and characterization of additional flagellin genes from Vibrio anguillarum[J].Journal of Bacteriology,1996,178(17):5188-5198.
[14] DUAN Q D,ZHOU M X,ZHU X F,et al.The flagella of F18ab
Escherichia coli is a virulence factor that contributes to infection in a IPEC-J2 cell model in vitro[J].Veterinary Microbiology,2012,160(1/2):132-140.
[15] VERMA S,PRESCOTT R A,INGANO L,et al.The YrbE phospholipid transporter of
Salmonella enterica serovar Typhi regulates the expression of flagellin and influences motility,adhesion and induction of epithelial inflammatory responses[J].Gut Microbes,2019,12:1-13.
[16] ASADISHAD B,HIDALGO G,TUFENKJI N.Pomegranate materials inhibit flagellin gene expression and flagellar-propelled motility of uropathogenic
Escherichia coli strain CFT073[J].FEMS Microbiology Letters,2012,334(2):87-94.
[17] FORSTNERI? V,IVI?AK-KOCJAN K,LJUBET? A,et al Distinctive recognition of flagellin by human and mouse toll-like receptor 5[J].PLoS One,2016,11(7):e0158894.
[18] HAJAM I A,DAR P A,SHAHNAWAZ I,et al.Bacterial flagellin-a potent immunomodulatory agent[J].Experimental & Molecular Medicine,2017,49(9):e373.
[19] TRAN H Q,LEY R E,GEWIRTZ A T,et al.Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases[J].Nature Communications,2019,10:5650.
[20] ANDERSEN-NISSEN E,SMITH K D,STROBE K L,et al.Evasion of Toll-like receptor 5 by flagellated bacteria[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(26):9247-9252.
[21] DICKEY A K,CHANTRATITA N,TANDHAVANANT S,et al.Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to
Burkholderia pseudomallei[J].PLoS Neglected Tropical Diseases,2019,13(5):e0007354.
[22] HANEY C H.Innate immunity in plants and animals[J].Biochemist,2014,36(5):1-5.
[23] TAHOUN A,JENSEN K,CORRIPIO-MIYAR Y,et al.Host species adaptation of TLR5 signalling and flagellin recognition[J].Scientific Reports,2017,7:17677.
[24] GONZÁLEZ-STEGMAIER R,GUZMÁN F,ALBERICIO F,et al.A synthetic peptide derived from the D1 domain of flagellin induced the expression of proinflammatory cytokines in fish macrophages[J].Fish & Shellfish Immunology,2015,47(1):239-244.
[25] GONZÁLEZ-STEGMAIER R,ROMERO A,ESTEPA A,et al.Effects of recombinant flagellin B and its ND1 domain from
Vibrio anguillarum on macrophages from gilthead seabream (
Sparus aurata L.) and rainbow trout (
Oncorhynchus mykiss,W.)[J].Fish & Shellfish Immunology,2015,42(1):144-152.
[26] 罗佳,李薇,段云峰,等.Toll样受体5和鞭毛蛋白的相互作用影响宿主区分病原菌和益生菌[J].微生物学通报,2014,41(7):1368-1375.
[27] 卢军锋.益生菌发酵饲料对育肥猪免疫指标和肠道健康的影响[D].硕士学位论文.杨凌:西北农林科技大学,2019.
[28] VIJAY-KUMAR M,AITKEN J D,CARVALHO F A,et al.Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5[J].Science,2010,328(5975):228-231.
[29] CARVALHO F A,KOREN O,GOODRICH J K,et al.Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice[J].Cell Host & Microbe,2012,12(2):139-152.
[30] 朱学农,谭玉文,史宪伟.大河乌猪
TLR5基因变异与经济性状的相关性分析[C]//第十一次全国畜禽遗传标记研讨会论文集.青岛:中国畜牧兽医学会,2008:195-201.
[31] SHARMA P,LEVY O,DOWLING D J.The TLR5 agonist flagellin modifies phenotypical and enhances functional activation of lung mucosal antigen presenting cells in neonatal mice[J].bioRxiv,2019,doi:10.1101/564054.
[32] VIJAYAN A,RUMBO M,CARNOY C,et al.Compartmentalized antimicrobial defenses in response to flagellin[J].Trends in Microbiology,2018,26(5):423-435.
[33] HORSTMANN J A,ZSCHIESCHANG E,TRUSCHEL T,et al.Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive
Salmonella gut colonisation[J].Cellular Microbiology,2017,19(8):e12739.
[34] KIM E H,KIM J H,SAMIVEL R,et al.Intralymphatic treatment of flagellin-ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis[J].Allergy,2016,71(5):629-639.
[35] LI Q N,XU Z X,WU T T,et al.A flagellin-adjuvanted PED subunit vaccine improved protective efficiency against PEDV variant challenge in pigs[J].Vaccine,2018,36(29):4228-4235.
[36] HE B,XU W F,SANTINI P A,et al.Intestinal bacteria trigger T cell-independent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL[J].Immunity,2007,26(6):812-826.
[37] 崔保峰.基于鞭毛蛋白载体的口蹄疫表位疫苗研究[D].博士学位论文.北京:中国农业科学院,2019.
[38] KIM M I,LEE C,PARK J,et al.Crystal structure of
Bacillus cereus flagellin and structure-guided fusion-protein designs[J].Scientific Reports,2018,8:5814.
[39] METT V,KOMAROVA E A,GREENE K,et al.Mobilan:a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy[J].Oncogene,2018,37(4):439-449.
[40] HONG M S,LEE P S,HOFFMAN R M B,et al.Antibody recognition of the pandemic H1N1 influenza virus hemagglutinin receptor binding site[J].Journal of Virology,2013,87(22):12471-12480.
[41] 梁海鹰,陈永新,简纪常,等.溶藻弧菌鞭毛蛋白flaC基因DNA疫苗对红笛鲷的免疫保护[J].水产学报,2013,37(1):125-131.
