Effects of Saccharomyces boulardii Cell Wall Polysaccharides on Diarrhea and Intestinal Mucosal Immunity of Early-Weaned Lambs

  • LIU Mengjian ,
  • ZHANG Wenju ,
  • YAO Jun
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  • College of Animal Science and Technology, Shihezi University, Shihezi 832000, China

Received date: 2020-03-14

  Online published: 2020-09-17

Abstract

This experiment was conducted to determine the effects of Saccharomyces boulardii cell wall polysaccharides on diarrhea and intestinal mucosal immunity of early-weaned lambs. A single factor random experiment design was used and 60 lambs with similar health condition, parity and body weight which weaned at 15 to 17 days of age were randomly allotted to 5 groups with 3 replicates in each group and 4 lambs in each replicate. Lambs in the 4 groups were fed milk replacer (group Ⅰ), milk replacer+0.005% gentamicin (group Ⅱ), milk replacer+0.1% Saccharomyces boulardii cell wall polysaccharide (group Ⅲ), milk replacer+0.3% Saccharomyces boulardii cell wall polysaccharide (group Ⅳ) and milk replacer+0.5% Saccharomyces boulardii cell wall polysaccharide (group Ⅴ), respectively. The experiment lasted for 44 days, including transition period, preliminary period and test period, and they were designed to 8, 7 and 29 days, respectively. The results showed as follows:1) the fecal index of groups Ⅳ and Ⅴ was significantly lower than that of group Ⅰ by 20.73% and 15.85% (P<0.05), respectively; the diarrhea rate of groups Ⅳ and Ⅴ was significantly lower than that of group Ⅰ by 31.34% and 23.75% (P<0.05). 2) The secreted immunoglobulin A (sIgA) content in colonic mucosa of groups Ⅳ and Ⅴ was significantly higher than that of group Ⅰ by 14.49% and 17.77% (P<0.05), respectively; the immunoglobulin A (IgA) content in colonic mucosa of group Ⅲ was significantly higher than that of group I by 5.81% (P<0.05); the interleukin-1 (IL-1) content in colonic mucosa of groups Ⅳ and Ⅴ was significantly lower than that of group I by 7.93% and 10.58% (P<0.05), respectively; the interleukin-10 (IL-10) content in colonic mucosa of group Ⅳ was significantly higher than that of group Ⅰ by 8.05% (P<0.05). Moreover, the immunoglobulin G (IgG) content increased and the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) decreased in colonic mucosa of groups Ⅳ and Ⅴ compared with group Ⅰ, but the differences were not significant (P>0.05). The above results indicate that adding 0.3% to 0.5% Saccharomyces boulardii cell wall polysaccharide in the milk replacer can decrease the diarrhea rate of early-weaned lambs in a certain degree, and enhance the intestinal mucosal immune level.

Cite this article

LIU Mengjian , ZHANG Wenju , YAO Jun . Effects of Saccharomyces boulardii Cell Wall Polysaccharides on Diarrhea and Intestinal Mucosal Immunity of Early-Weaned Lambs[J]. Chinese Journal of Animal Nutrition, 2020 , 32(9) : 4205 -4211 . DOI: 10.3969/j.issn.1006-267x.2020.09.030

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