[1] YANG H,XIAO Y P,WANG J J,et al.Core gut microbiota in
Jinhua pigs and its correlation with strain,farm and weaning age[J].Journal of Microbiology,2018,56(5):346-355.

[2] PAJARILLO E A,CHAE J P,BALOLONG M P,et al.Pyrosequencing-based analysis of fecal microbial communities in three purebred pig lines[J].Journal of Microbiology,2014,52(8):646-651.

[3] PAJARILLO E A,CHAE J P,BALOLONG M P,et al.Characterization of the fecal microbial communities of Duroc pigs using 16S rRNA gene pyrosequencing[J].Asian-Australasian Journal of Animal Sciences,2015,28(4):584-591.

[4] DIAO H,YAN H L,XIAO Y,et al.Intestinal microbiota could transfer host gut characteristics from pigs to mice[J].BMC Microbiology,2016,16:238.
[5] ZENG B,ZHANG S Y,XU H L,et al.Gut microbiota of Tibetans and Tibetan pigs varies between high and low altitude environments[J].Microbiological Research,2020,235:126447.
[6] XIAO Y P,KONG F L,XIANG Y,et al.Comparative biogeography of the gut microbiome between
Jinhua and Landrace pigs[J].Scientific Reports,2018,8:5985.
[7] CRESPO-PIAZUELO D,MIGURA-GARCIA L,ESTELLÉ J,et al.Association between the pig genome and its gut microbiota composition[J].Scientific Reports,2019,9(1):8791.
[8] WANG X F,TSAI T,DENG F L,et al.Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria[J].Microbiome,2019,7:109.
[9] BIAN G R,MA S Q,ZHU Z G,et al.Age,introduction of solid feed and weaning are more important determinants of gut bacterial succession in piglets than breed and nursing mother as revealed by a reciprocal cross-fostering model[J].Environmental Microbiology,2016,18(5):1566-1577.

[10] KUBASOVA T,DAVIDOVA-GERZOVA L,MERLOT E,et al.Housing systems influence gut microbiota composition of sows but not of their piglets[J].PLoS One,2017,12(1):e170051.
[11] GRZESKOWIAK L,ZENTEK J,VAHJEN W.Determination of the extent of
Clostridium difficile colonisation and toxin accumulation in sows and neonatal piglets[J].Anaerobe,2016,40:5-9.
[12] LI Y,WANG X F,WANG X Q,et al.Life-long dynamics of the swine gut microbiome and their implications in probiotics development and food safety[J].Gut Microbes,2020,11(6):1824-1832.

[13] HAN G G,LEE J Y,JIN G D,et al.Tracing of the fecal microbiota of commercial pigs at five growth stages from birth to shipment[J].Scientific Reports,2018,8:6012.
[14] KIM H B,BOREWICZ K,WHITE B A,et al.Longitudinal investigation of the age-related bacterial diversity in the feces of commercial pigs[J].Veterinary Microbiology,2011,153(1/2):124-133.
[15] LIU Y,ZHENG Z J,YU L H,et al.Examination of the temporal and spatial dynamics of the gut microbiome in newborn piglets reveals distinct microbial communities in six intestinal segments[J].Scientific Reports,2019,9:3453.
[16] ABELILLA J J,STEIN H H.Degradation of dietary fiber in the stomach,small intestine,and large intestine of growing pigs fed corn- or wheat-based diets without or with microbial xylanase[J].Journal of Animal Science,2019,97(1):338-352.

[17] ZHANG L,WU W D,LEE Y K,et al.Spatial heterogeneity and co-occurrence of mucosal and luminal microbiome across swine intestinal tract[J].Frontiers in Microbiology,2018,9:48.
[18] JIANG L L,FENG C P,TAO S Y,et al.Maternal imprinting of the neonatal microbiota colonization in intrauterine growth restricted piglets:a review[J].Journal of Animal Science and Biotechnology,2019,10:88.
[19] CHEN X,XU J M,REN E D,et al.Co-occurrence of early gut colonization in neonatal piglets with microbiota in the maternal and surrounding delivery environments[J].Anaerobe,2018,49:30-40.
[20] LIU H B,ZENG X F,ZHANG G L,et al.Maternal milk and fecal microbes guide the spatiotemporal development of mucosa-associated microbiota and barrier function in the porcine neonatal gut[J].BMC Biology,2019,17:106.
[21] VAL-LAILLET D,BESSON M,GUÉRIN S,et al.A maternal Western diet during gestation and lactation modifies offspring's microbiota activity,blood lipid levels,cognitive responses,and hippocampal neurogenesis in Yucatan pigs[J].The FASEB Journal,2017,31(5):2037-2049.

[22] WANG W L,HU H F,ZIJLSTRA R T,et al.Metagenomic reconstructions of gut microbial metabolism in weanling pigs[J].Microbiome,2019,7:48.
[23] ZHOU L P,FANG L D,SUN Y,et al.Effects of a diet high in resistant starch on fermentation end-products of protein and mucin secretion in the colons of pigs[J].Starch-Stärke,2017,69(7/8):1600032.
[24] HE X Y,SUN W W,GE T,et al.An increase in corn resistant starch decreases protein fermentation and modulates gut microbiota during
in vitro cultivation of pig large intestinal inocula[J].Animal Nutrition,2017,3(3):219-224.

[25] GAO K,PI Y,PENG Y,et al.Time-course responses of ileal and fecal microbiota and metabolite profiles to antibiotics in cannulated pigs[J].Applied Microbiology and Biotechnology,2018,102(5):2289-2299.

[26] MU C L,YANG Y X,YU K F,et al.Alteration of metabolomic markers of amino-acid metabolism in piglets with in-feed antibiotics[J].Amino Acids,2017,49(4):771-781.

[27] HUANG S M,WU Z H,LI T T,et al.Perturbation of the lipid metabolism and intestinal inflammation in growing pigs with low birth weight is associated with the alterations of gut microbiota[J].Science of the Total Environment,2020,719:137382.
[28] MCCORMACK U M,CURIÃO T,BUZOIANU S G,et al.Exploring a possible link between the intestinal Microbiota and feed efficiency in pigs[J].Applied and Environmental Microbiology,2017,83(15):e00380-17.
[29] YANG H,XIANG Y,ROBINSON K,et al.Gut microbiota is a major contributor to adiposity in pigs[J].Frontiers in Microbiology,2018,9:3045.
[30] KERR B J,YEN J T,NIENABER J A,et al.Influences of dietary protein level,amino acid supplementation and environmental temperature on performance,body composition,organ weights and total heat production of growing pigs[J].Journal of Animal Science,2003,81(8):1998-2007.

[31] CHE L Q,PENG X,HU L,et al.The addition of protein-bound amino acids in low-protein diets improves the metabolic and immunological characteristics in fifteen- to thirty-five-kg pigs[J].Journal of Animal Science,2017,95(3):1277-1287.
[32] SHEN J H,WANG H S,PI Y,et al.Casein hydrolysate supplementation in low-crude protein diets increases feed intake and nitrogen retention without affecting nitrogen utilization of growing pigs[J].Journal of the Science of Food and Agriculture,2020,100(4):1748-1756.

[33] YUE L Y,QIAO S Y.Effects of low-protein diets supplemented with crystalline amino acids on performance and intestinal development in piglets over the first 2 weeks after weaning[J].Livestock Science,2008,115(2/3):144-152.
[34] LI Y Y,LU X X,WU H Q,et al.The effect of dietary supplementation of low crude protein on intestinal morphology in pigs[J].Research in Veterinary Science,2019,122:15-21.
[35] HOU Q,XIA M,HU W,et al.The effect of low protein on colonic mucosal barrier in pigs[J].International Journal of Morpholohy,2017,35(3):877-882.

[36] CHEN X,SONG P,FAN P,et al.Moderate dietary protein restriction optimized gut microbiota and mucosal barrier in growing pig model[J]. Frontiers in Cellular and Infection Microbiology,2018,8:246.
[37] FAN P,LIU P,SONG P,et al.Moderate dietary protein restriction alters the composition of gut microbiota and improves ileal barrier function in adult pig model[J].Scientific Reports,2017,7:43412.
[38] DAVILA A M,BLACHIER F,GOTTELAND M,et al.Intestinal luminal nitrogen metabolism:role of the gut microbiota and consequences for the host[J].Pharmacological Research,2013,68(1):95-107.

[39] FAN P,LI L,REZAEI A,et al.Metabolites of dietary protein and peptides by intestinal microbes and their impacts on gut[J].Current Protein & Peptide Science,2015,16(7):646-654.

[40] PENG Y,YU K,MU C,et al.Progressive response of large intestinal bacterial community and fermentation to the stepwise decrease of dietary crude protein level in growing pigs[J].Applied Microbiology and Biotechnology,2017,101(4):1-12.
[41] HE L,WU L,XU Z,et al.Low-protein diets affect ileal amino acid digestibility and gene expression of digestive enzymes in growing and finishing pigs[J].Amino Acids,2016,48(1):21-30.

[42] PSICHAS A,SLEETH M L,MURPHY K G,et al.The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents[J].International Journal of Obesity,2015,39(3):424-429.

[43] GAO K,PI Y,MU C L,et al.Antibiotics-induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets[J].Journal of Neurochemistry,2018,146(3):219-234.

[44] GAO K,PI Y,MU C L,et al.Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis:aromatic amino acids linking the microbiota-brain axis[J].Journal of Neurochemistry,2019,149(5):641-659.

[45] VAL-LAILLET D,GUÉRIN S,COQUERY N,et al.Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis,with limited effects on gut anatomy and function in pigs[J].The FASEB Journal,2017,32(4):2160-2171.
[46] YI H B,YANG G D,XIONG Y X,et al.Integrated metabolomic and proteomics profiling reveals the promotion of
Lactobacillus reuteri LR1 on amino acid metabolism in the gut-liver axis of weaned pigs[J].Food & Function,2019,10(11):7387-7396.

[47] PI Y,MU C L,GAO K,et al.Increasing the hindgut carbohydrate/protein ratio by cecal infusion of corn starch or casein hydrolysate drives gut microbiota-related bile acid metabolism to stimulate colonic barrier function[J].mSystems,2020,5(3):e00176-20.
[48] THAISS C A,LEVY M,KOREM T,et al.Microbiota diurnal rhythmicity programs host transcriptome oscillations[J].Cell,2016,167(6):1495-1510.e12.

[49] LEONE V,GIBBONS S M,MARTINEZ K,et al.Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism[J].Cell Host Microbe,2015,17(5):681-689.

[50] THAISS C A,ZEEVI D,LEVY M,et al.Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis[J].Cell,2014,159(3):514-529.

[51] ZARRINPAR A,CHAIX A,YOOSEPH S,et al.Diet and feeding pattern affect the diurnal dynamics of the gut microbiome[J].Cell Metabolism,2014,20(6):1006-1017.

[52] THAISS C A,LEVY M,ELINAV E.Chronobiomics:the biological clock as a new principle in host-microbial interactions[J].PLoS Pathogens,2015,11(10):e1005113.
[53] TOGNINI P,MURAKAMI M,LIU Y,et al.Distinct circadian signatures in liver and gut clocks revealed by ketogenic diet[J].Cell Metabolism,2017,26(3):523-538.e5.

[54] MARTINEZ-GURYN K,HUBERT N,FRAZIER K,et al.Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids[J].Cell Host Microbe,2018,23(4):458-469.e5.

[55] SUN S M,HANZAWA F,UMEKI M,et al.Impacts of high-sucrose diet on circadian rhythms in the small intestine of rats[J].Chronobiology International,2019,36(6):826-837.

[56] MUKHERJI A,KOBⅡTA A,YE T,et al.Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs[J].Cell,2013,153(4):812-827.

[57] WANG Y H,KUANG Z,YU X F,et al.The intestinal microbiota regulates body composition through NFIL3 and the circadian clock[J].Science,2017,357(6354):912-916.

[58] 虞德夫,朱晓峰,冯江银,等.低蛋白质日粮对断奶仔猪生长相关激素和肠道微生物区系的影响[J].微生物学报,2019,59(9):1695-1704.
[59] SHI Q,ZHU Y,WANG J,et al.Protein restriction and succedent realimentation affecting ileal morphology,ileal microbial composition and metabolites in weaned piglets[J].Animal,2019,13(11):2463-2472.

[60] 刘壮,慕春龙,彭宇,等.极低蛋白日粮补充不同形式氮营养素对生长猪回肠食糜菌群、代谢产物和屏障功能的影响[J].南京农业大学学报,2019,42(3):526-534.
[61] WANG H,SHEN J,PI Y,et al.Low-protein diets supplemented with casein hydrolysate favor the microbiota and enhance the mucosal humoral immunity in the colon of pigs[J].Journal of Animal Science and Biotechnology,2019,10(1):1-13.

[62] JI Y J,GUO Q P,YIN Y L,et al.Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in
Huanjiang mini-pigs[J].Journal of Animal Science and Biotechnology,2018,9:18.
[63] 颜桂花,邢恒涛,刘强,等.可溶性玉米纤维对仔猪盲肠微生物多样性的影响[J].南京农业大学学报,2020,43(3):505-513.
[64] 王嘉为,张蕾,祝皎月,等.饲粮中添加苜蓿草粉对生长猪结肠微生物区系及其代谢产物的影响[J].动物营养学报,2016,28(9):2715-2723.
[65] 毛湘冰,汤俊,陈代文,等.饲粮添加鼠李糖乳酸杆菌GG对轮状病毒感染的断奶仔猪回肠黏膜屏障功能的影响[J].四川农业大学学报,2019,37(1):78-82,91.
[66] MAO J D,QI S R,CUI Y J,et al.
Lactobacillus rhamnosus GG attenuates lipopolysaccharide-induced inflammation and barrier dysfunction by regulating MAPK/NF-κB signaling and modulating metabolome in the piglet intestine[J].The Journal of Nutrition,2020,150(5):1313-1323.

[67] 李雪莉,虞徳夫,王超,等.植物乳杆菌制剂对断奶仔猪肠道黏膜功能和微生物菌群及短链脂肪酸的影响[J].南京农业大学学报,2018,41(3):504-510.
[68] 赵秀英,县怡涵,李晨博,等.灌喂植物乳杆菌和干酪乳杆菌增加仔猪肠道菌群多样性及短链脂肪酸生成[J].微生物学报,2016,56(8):1291-1300.
[69] SU Y T,CHEN X J,LIU M,et al.Effect of three lactobacilli with strain-specific activities on the growth performance,faecal microbiota and ileum mucosa proteomics of piglets[J].Journal of Animal Science and Biotechnology,2017,8:52.
[70] PENG X,WANG R,HU L,et al.
Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic
Escherichia coli K88[J].Journal of Animal Science and Biotechnology,2019,10:72.
[71] CHEN L,LI S,ZHENG J,et al.Effects of dietary
Clostridium butyricum supplementation on growth performance,intestinal development,and immune response of weaned piglets challenged with lipopolysaccharide[J].Journal of Animal Science and Biotechnology,2018,9:62.
[72] LI Y,ZHANG H,SU W P,et al.Effects of dietary
Bacillus amyloliquefaciens supplementation on growth performance,intestinal morphology,inflammatory response,and microbiota of intra-uterine growth retarded weanling piglets[J].Journal of Animal Science and Biotechnology,2018,9:22.
[73] 张铮,朱坤,朱伟云,等.发酵饲料对生长育肥猪结肠微生物发酵及菌群组成的影响[J].微生物学报,2019,59(1):93-102.
[74] 王彬,刘俊泽,陈志杰,等.甘蔗提取物对敌草快诱导断奶仔猪氧化损伤的防护效果及肠道微生物参与的机制[J].南京农业大学学报,2020,43(3):514-522.
[75] WANG T X,YAO W L,LI J,et al.Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets[J].Journal of Animal Science and Biotechnology,2020,11:12.
[76] XU X,HUA H W,WANG L M,et al.Holly polyphenols alleviate intestinal inflammation and alter microbiota composition in lipopolysaccharide-challenged pigs[J].British Journal of Nutrition,2020,123(8):881-891.

[77] WU Y,MA N,SONG P X,et al.Grape seed proanthocyanidin affects lipid metabolism via changing gut microflora and enhancing propionate production in weaned pigs[J].The Journal of Nutrition,2019,149(9):1523-1532.

[78] WEI H K,XUE H X,ZHOU Z X,et al.A carvacrol-thymol blend decreased intestinal oxidative stress and influenced selected microbes without changing the messenger RNA levels of tight junction proteins in jejunal mucosa of weaning piglets[J].Animal,2017,11(2):193-201.

[79] 赵瑶,张玲,何俊,等.不同纤维源替代部分基础日粮对生长猪生产性能、养分消化率及肠道生理的影响[J].四川农业大学学报,2019,37(4):533-541.
[80] 胡瑶莲,张恒志,陈代文,等.白藜芦醇对生长育肥猪抗氧化能力、空肠黏膜免疫及结肠菌群的影响[J].动物营养学报,2019,31(1):459-468.
[81] 于光辉,王煜琦,刘正方,等.半胱胺螯合锌对育肥猪免疫性能、抗氧化能力、血清生化指标及肠道微生物的影响[J].动物营养学报,2020,32(4):1891-1898.
[82] 陈雪,任二都,苏勇.早期灌喂母源粪菌对新生仔猪肠道菌群发育的影响[J].微生物学报,2018,58(7):1224-1232.
[83] CHENG C S,WEI H K,WANG P,et al.Early intervention with faecal microbiota transplantation:an effective means to improve growth performance and the intestinal development of suckling piglets[J].Animal,2019,13(3):533-541.

[84] YU M,MU C L,ZHANG C J,et al.Long-term effect of early antibiotic exposure on amino acid profiles and gene expression of transporters and receptors in the small intestinal mucosa of growing pigs with different dietary protein levels[J].Journal of the Science of Food and Agriculture,2020,100(1):235-244.

[85] XU R Y,WAN J J,LIN C H,et al.Effects of early intervention with antibiotics and maternal fecal microbiota on transcriptomic profiling ileal mucusa in neonatal pigs[J].Antibiotics,2020,9(1):35.
[86] LIN C H,WAN J J,SU Y,et al.Effects of early intervention with maternal fecal microbiota and antibiotics on the gut microbiota and metabolite profiles of piglets[J].Metabolites,2018,8(4):89.
[87] WAN J J,LIN C H,REN E D,et al.Effects of early intervention with maternal fecal bacteria and antibiotics on liver metabolome and transcription in neonatal pigs[J].Frontiers in Physiology,2019,10:171.
[88] 赵方舟,胡平,汪晶,等.早期乳铁蛋白干预对哺乳仔猪盲肠菌群结构、短链脂肪酸及黏膜炎症因子的影响[J/OL].南京农业大学学报,2020:1-15[2020-04-29].https://kns.cnki.net/KCMS/detail/32.1148.S.20200429.1720.002.html.
[89] ZHAO X,FU H Y,QIU S N,et al.Effects of early protein restriction on the growth performance and gut development of pigs fed diets with or without antibiotic[J].Animal,2019,14(7):1392-1401.