The purpose of this study was to investigate the effects of different dietary levels of compound enzyme preparation (containing 850 U/g xylanase, 750 U/g cellulase, 50 U/g β-glucanase and 2 000 U/kg phytase) on endogenous digestive enzyme activity and nutrient utilization in wheat-soybean meal type diet for broilers. A total of 336 one-day-old Arbor Acres male broiler chickens were randomly divided into 7 groups with 6 replicates in each group and 8 chickens in each replicate. The control group Ⅰ was fed a corn-soybean meal type diet, the control group Ⅱ was fed a wheat-soybean meal type diet, and the experimental groups Ⅰ, Ⅱ, Ⅲ, Ⅳ and Ⅴ were fed the wheat-soybean meal type diets supplemented with 1 000, 1 500, 2 000, 2 500 and 3 000 mg/kg compound enzyme preparation, respectively. The experiment lasted for 42 days. The results showed as follows: 1) at the age of 21 and 42 days, the pepsin activity in glandular stomach and muscle stomach of broilers in experimental group Ⅲ was slightly lower than that in the control group Ⅰ (P>0.05), which in the other experimental groups was extremely significantly lower than that in the control group Ⅰ (P<0.01). 2) The activities of amylase, trypsin and chymotrypsin in pancreas of broilers at the age of 42 days in experimental group Ⅲ were not significantly different compared with the control group Ⅰ (P>0.05), while those of broilers at the age of 21 and 42 days in the other experimental groups were significantly or extremely significantly lower than those in the control group Ⅰ (P<0.05 or P<0.01). The lipase activity in pancreas of broilers at the age of 21 days in experimental groups Ⅰ to Ⅴ and broilers at the age of 42 days in experimental group Ⅲ was not significantly different compared with the control group Ⅰ (P>0.05). 3) At the age of 42 days, the activities of amylase, lipase and trypsin in duodenum of broilers in experimental group Ⅲ and the activities of lipase and trypsin in duodenum of broilers in experimental group Ⅳ were not significantly different compared with the control group Ⅰ (P>0.05). The chymotrypsin activity in duodenum of broilers at the age of 21 days in experimental groups Ⅱ to Ⅴ and broilers at the age of 42 days in experimental groups Ⅲ to Ⅳ was not significantly different compared with the control group Ⅰ (P>0.05). The above indices in the other experimental groups were significantly or extremely significantly lower than those in the control group Ⅰ (P<0.05 or P<0.01). 4) At the age of 21 days, the activities of amylase and trypsin in jejunum of broilers in experimental group Ⅲ and the activities of lipase and chymotrypsin of broilers in experimental groups Ⅲ and Ⅳ were slightly lower than those in the control group Ⅰ (P>0.05). At the age of 42 days, the amylase activity in jejunum of broilers in experimental groups Ⅲ to Ⅳ, the lipase activity in jejunum of broilers in experimental groups Ⅱ to Ⅲ, and the chymotrypsin activity of broilers in experimental group Ⅲ were not significantly different compared with the control group Ⅰ (P>0.05). The above indices in the other experimental groups were significantly or extremely significantly lower than those in the control group Ⅰ (P<0.05 or P<0.01). 5) The activities of amylase, lipase, trypsin and chymotrypsin in ileum of broilers at the age of 21 days in experimental groups Ⅲ and Ⅳ and broilers at the age 42 days in experimental group Ⅲ were slightly lower than those in the control group Ⅰ (P>0.05), but those in the other experimental groups (except for experimental group Ⅳ at the age of 21 days) were extremely significantly lower than those in the control group Ⅰ (P<0.01). 6) Compared with the control group Ⅱ, the endogenous digestive enzyme activities in glandular stomach, muscle stomach, pancreas and all small intestine paragraphs of broilers in experimental groups Ⅱ to Ⅴ were significantly or extremely significantly increased (P<0.05 or P<0.01). 7) The apparent utilization and true utilization of dietary gross energy, ether extract and crude protein of broilers at the age of 21 days in experimental groups Ⅲ to Ⅴ and broilers at the age of 42 days in experimental groups Ⅳ to Ⅴ were not significantly different compared with the control group Ⅰ (P>0.05), which in the other experimental groups were significantly or extremely significantly lower than those in the control group Ⅰ (P<0.05 or P<0.01), and those in the experimental groups Ⅲ to Ⅴ at the age of 21 and 42 days were significantly higher than those in the control group Ⅱ (P<0.05 or P<0.01). At the age of 21 days, the calcium apparent utilization of broilers in experimental groups Ⅳ to Ⅴ and the calcium true utilization of broilers in experimental group Ⅴ were significantly or extremely significantly higher than those in the control groups Ⅰ and Ⅱ (P<0.05 or P<0.01). At the age of 42 days, the apparent utilization and true utilization of calcium of broilers in experimental groups Ⅳ to Ⅴ were extremely significantly higher than those in the control group Ⅱ (P<0.01). The apparent utilization and true utilization of phosphorus of broilers at the age of 42 days in experimental groups Ⅲ to Ⅴ were extremely significantly higher than those in the control group Ⅰ (P<0.01), and the apparent utilization and true utilization of phosphorus of broilers at the age of 21 and 42 days in experimental groups Ⅱ to Ⅴ were significantly or extremely higher than those in the control group Ⅱ (P<0.05 or P<0.01). In conclusion, dietary 2 000 to 2 500 mg/kg exogenous compound enzyme preparation in wheat-soybean meal type diet for broilers can increase the endogenous digestive enzyme activities in digestive organs to be basically consistent with the corn-soybean meal type diet, and dietary 2 000 to 3 000 mg/kg exogenous compound enzyme preparation can increase the nutrient utilization of broilers to be close or better than the corn-soybean meal type diet.