Hypoxic Stress and Mitochondrial Function Mechanism in Animals

  • LU Yi ,
  • CAI Jie ,
  • WANG Diming ,
  • LIU Jianxin
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  • Institute of Dairy Science, College of Animal Science, Zhejiang University, Hangzhou 310029, China

Received date: 2020-04-02

  Online published: 2020-11-16

Abstract

Hypoxia is one of the important stress sources that animals face with changes in environment, disease, and metabolism, which can lead to the imbalance of free radical homeostasis and damage to cells. Mitochondria are the most important organelles that sense changes in oxygen and produce reactive oxygen species (ROS), and adapt to hypoxia through mass control and changes in energy metabolism. Hypoxia can activate hypoxia-inducible factor-1 (HIF-1) to participate in the regulation of hypoxia compensation mechanism and reduce cellular damage caused by reactive oxygen species. Meanwhile, the increase in mitochondrial biosynthesis may be a new strategy for mitochondria to resist against hypoxic stress and improve the adaptability of the body. This article reviewed the classification of hypoxic stress in animals and focused on the adaptive regulatory mechanism of HIF-1 and changes in mitochondrial function at the cellular and molecular levels.

Cite this article

LU Yi , CAI Jie , WANG Diming , LIU Jianxin . Hypoxic Stress and Mitochondrial Function Mechanism in Animals[J]. Chinese Journal of Animal Nutrition, 2020 , 32(11) : 5046 -5052 . DOI: 10.3969/j.issn.1006-267x.2020.11.009

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