Research Progress of Effects of Diet Nutrients on Intestinal Tight Junction Protein Zonula Occludens-1 of Fish

  • KONG Yaoyao ,
  • MA Xiuhua ,
  • MAI Kangsen ,
  • ZHANG Yanjiao
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  • 1. Key Laboratory of Aquaculture Nutrition and Feeds, Ministry of Agriculture, Key Laboratory of Mariculture Ministry of Education, Ocean University of China, Qingdao 266003, China;
    2. Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China

Received date: 2020-03-31

  Online published: 2020-11-16

Abstract

The intestinal tight junction structure of fish is an important component of intestinal mucosal barrier. Tight junction forms complex protein structure maintained by transmembrane proteins (eg. Claudin and Occludin) and cytoplasmic proteins [eg. zonula occludens-1 (ZO-1)] between adjacent epithelial cells. Cytoplasmic tight junction protein ZO-1 is a member of the membrane associated guanosine kinase (MAGUK) family, it is one of the most important proteins in tight junction. ZO-1 plays an important role in maintaining cell polarity and tight junction barrier function, which is closely related to the occurrence of intestinal diseases. As it was known, the nutrients in diet can affect and regulate the expression of ZO-1 to some extent. Therefore, the review presents the effects of the five nutrients, such as protein, fat, carbohydrate, vitamins and minerals, on intestinal tight junction protein ZO-1 and the potential mechanism in fish, which will be helpful to maintain the integrity of fish intestinal barrier and improve the feed utilization efficiency.

Cite this article

KONG Yaoyao , MA Xiuhua , MAI Kangsen , ZHANG Yanjiao . Research Progress of Effects of Diet Nutrients on Intestinal Tight Junction Protein Zonula Occludens-1 of Fish[J]. Chinese Journal of Animal Nutrition, 2020 , 32(11) : 5081 -5088 . DOI: 10.3969/j.issn.1006-267x.2020.11.014

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