Similarities and Differences of Niacin and Niacinamide in Study on Metabolism and Production of Ruminant

WEI Xiaoshi; YAO Junhu; WANG Chong

doi:10.3969/j.issn.1006-267x.2020.12.003

Chinese Journal of Animal Nutrition >

2020 , Vol. 32 >Issue 12: 5509 - 5515

DOI: https://doi.org/10.3969/j.issn.1006-267x.2020.12.003

Similarities and Differences of Niacin and Niacinamide in Study on Metabolism and Production of Ruminant

WEI Xiaoshi ,
YAO Junhu ,
WANG Chong

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1. College of Animal Science and Technology/College of Veterinary Medicine, Zhejiang Agricultural and Forestry University, Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, Hangzhou 311300, China;
2. College of Animal Science and Technology, Northwest Agricultural and Forestry University, Yangling 712100, China

Received date: 2020-05-15

Online published: 2020-12-07

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Abstract

The nicotinic acid (NA) and nicotinamide (NAM) are two forms of water-soluble B vitamins, also known as vitamin PP. They are involved in the body’s synthesis and catabolism and the metabolisms of carbohydrate, lipid and protein. As an important vitamin, they play important regulatory roles in energy metabolism and oxidative stress of ruminant. In this review, we summarized the effect and regulation mechanism of NA and NAM in ruminant, and compared their similarities and differences, aiming to provide reference for the related research of NA and NAM and their application in production.

Key words： nicotinic acid; nicotinamide; lipid regulation; oxidative stress; similarities and differences

Cite this article

WEI Xiaoshi , YAO Junhu , WANG Chong . Similarities and Differences of Niacin and Niacinamide in Study on Metabolism and Production of Ruminant[J]. Chinese Journal of Animal Nutrition, 2020 , 32(12) : 5509 -5515 . DOI: 10.3969/j.issn.1006-267x.2020.12.003

References

[1] BELENKY P,BOGAN K L,BRENNER C.NAD⁺ metabolism in health and disease[J].Trends in Biochemical Science,2007,32:12-19.
[2] ROMANI M,HOFER D C,KATSYUBA E,et al.Niacin:an old lipid drug in a new NAD⁺ dress[J].Journal of Lipid Research,2019,60:741-746.
[3] CHEN J,YANG Z,DONG G.Niacin nutrition and rumen-protected niacin supplementation in dairy cows:an updated review[J].British Journal of Nutrition,2019,122:1103-1112.
[4] FRYE T,WILLIAMS S N,GRAHAM T W.Vitamin deficiencies in cattle[J].Veterinary Clinics of North America:Food Animal Practice,1991,7:217-275.
[5] BENAVENTE C A,JACOBSON M K,JACOBSON E L,et al.NAD in skin:therapeutic approaches for niacin[J].Current Pharmaceutical Design,2009,15(1):29-38.

[6] NIEHOFF I D,HÜTHER L,LEBZIEN P.Niacin for dairy cattle:a review[J].British Journal of Nutrition,2008,101:5-19.
[7] SECK M,LINTON J V,ALLEN M,et al.Apparent ruminal synthesis of B vitamins in lactating dairy cows fed diets with different forage-to-concentrate ratios[J].Journal of Dairy Science,2017,100:1914-1922.
[8] NIEHOFF I D,HUTHE L,LEBZIEN P,et al.Investigations on the effect of a niacin supplementation to three diets differing in forage-to-concentrate ratio on several blood and milk variables of dairy cows[J].Archives of Animal Nutrition,2009,63(3):203-218.

[9] SANTSCHI D E,BERTHIAUME R,MATTE J J,et al.Fate of supplementary B-vitamins in the gastrointestinal tract of dairy cows[J].Journal of Dairy Science,2005,88(6):2043-2054.

[10] SCHWAB E C,CARAVIELLO D Z,SHAVER R D. Review:a Meta-analysis of lactation responses to supplemental dietary niacin in dairy cows[J].The Professional Animal Scientist,2005,21(4):239-247.

[11] PIRES J A A,STUMPF L F,SOUTULLO I D,et al.Effects of abomasal infusion of nicotinic acid on responses to glucose and β-agonist challenges in underfed lactating cows[J].Journal of Dairy Science,2016,99:2297-2307.
[12] TIENKEN R,KERSTEN S,FRAHM J,et al.Effects of prepartum dietary energy level and nicotinic acid supplementation on immunological, hematological and biochemical parameters of periparturient dairy cows differing in parity[J].Animals,2015,5(3):910-933.

[13] WEI X S,CAI C J,HE J J,et al.Effects of biotin and nicotinamide supplementation on glucose and lipid metabolism and milk production of transition dairy cows[J].Animal Feed Science and Technology,2018,237:106-117.
[14] MOREY S D,MAMEDOVA L K,ANDERSON D E,et al.Effects of encapsulated niacin on metabolism and production of periparturient dairy cows[J].Journal of Dairy Science,2011,94(10):5090-5104.

[15] 魏筱诗.烟酰胺对围产期奶畜糖脂代谢及其子代肠道发育的影响和机制[D].博士学位论文.杨凌:西北农林科技大学,2019.
[16] 高雨飞.高精料日粮条件下烟酸对牛瘤胃微生物区系的影响[D].硕士学位论文.南昌:江西农业大学,2016.
[17] GILLE A,BODOR E T,AHMED K,et al.Nicotinic acid:pharmacological effects and mechanisms of action[J].Annual Review of Pharmacology and Toxicology,2008,48:79-106.
[18] 颜研.泌乳奶牛日粮烟酰胺适宜补饲量研究[D].硕士学位论文.山东:山东农业大学,2011.
[19] WEI X S,YIN Q Y,ZHAO H H,et al.Metabolomics for the effect of biotin and nicotinamide on transition dairy cows[J].Journal of Agricultural and Food Chemistry,2018,66:5723-5732.
[20] 赵会会.围产期奶山羊添加烟酰胺对羔羊糖脂代谢的影响及其机制[D].硕士学位论文.杨凌:西北农林科技大学,2018.
[21] LI M,SUN X,ZHOU Y,et al.Nicotinamide and resveratrol regulate bovine adipogenesis through a SIRT1-dependent mechanism[J].Journal of Functional Foods,2015,18:492-500.
[22] BAI L,PANG W J,YANG Y J,et al.Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes[J].Molecular and Cellular Biochemistry,2008,307(1/2):129-140.
[23] SHAPIRO A L B,BOYLE K E,DABELEA D,et al.Nicotinamide promotes adipogenesis in umbilical cord-derived mesenchymal stem cells and is associated with neonatal adiposity:the healthy start baby BUMP project[J].Plos One,2016,11(7):e0159575.
[24] WANG H,QIANG L,FARMER S R.Identification of a domain within peroxisome proliferator-activated receptor {gamma} regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes[J].Molecular and Cellular Biology,2008,28(1):188-200.

[25] HWANG E S,SONG S B.Nicotinamide is an inhibitor of SIRT1in vitro, but can be a stimulator in cells[J].Cellular and Molecular Life Sciences,2017,74(1):3347.
[26] YANG S J,CHOI J M,KIM L,et al.Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes[J].Journal of Nutritional Biochemistry,2014,25(1):66-72.

[27] ZIMBELMAN R B,COLLIER R J,BILBY T R.Effects of utilizing rumen protected niacin on core body temperature as well as milk production and composition in lactating dairy cows during heat stress[J].Animal Feed Science and Technology,2013,180(1):26-33.
[28] 王雪莹,王之盛,薛白,等.烟酸对热应激牦牛生长性能、营养物质表观消化率和血液指标的影响[J].动物营养学报,2020,32(5):2228-2240.
[29] GANJI S H,QIN S,ZHANG L,et al.Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells[J].Atherosclerosis,2009,202:68-75.
[30] GANJI S H,KASHYAP M L,KAMANNA V S.Niacin inhibits fat accumulation,oxidative stress,and inflammatory cytokine IL-8 in cultured hepatocytes:impact on non-alcoholic fatty liver disease[J].Metabolism,2015,64(9):982-990.

[31] WEI X S,ZHAO H H,HE J J,et al.Maternal nicotinamide supplementation during the perinatal period modifies the small intestine morphology and antioxidative status of offspring kids[J].Animal Feed Science and Technology,2019,252:41-50.
[32] ERSHUN Z,YIMENG L,MINJUN Y,et al.Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms[J].International Immunopharmacology,2014,23:121-126.
[33] LAPPAS M,PERMEZEL M.The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B₃ derivative, are elicited by FoxO3 in human gestational tissues:implications for preterm birth[J].Journal of Nutritional Biochemistry,2011,22(12):1195-1201.

[34] GRANGE P A,RAINGEAUD J,CALVEZ V,et al.Nicotinamide inhibits propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappa B and MAPK pathways[J].Journal of Dermatological Science,2009,56:106-112.
[35] LI D,SUN W P,ZHOU Y M,et al.Chronic niacin overload may be involved in the increased prevalence of obesity in US children[J].World Journal of Gastroenterology,2010,16,2378-2387.
[36] MROCHEK J E,JOLLEY R L,YOUNG D S,et al.Metabolic response of humans to ingestion of nicotinic acid andnicotinamide[J].Clinical Chemistry,1976,22,1821-1827.
[37] LI D,TIAN Y J,GUO J,et al.Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats[J].British Journal of Nutrition,2013,110:2156-2164.
[38] TIAN Y J,LUO N,CHEN N N,et al.Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats[J].British Journal of Nutrition,2014,111:1594-1601.
[39] BEDARD K, KRAUSE K H.The NOX family of ROS-generating NADPH oxidases:physiology and pathophysiology[J].Physiological Reviews,2007,87:245-313.
[40] RUTKOWSKI B,SLOMINSKA E,SZOLKIEWICZ M,et al.N-methyl-2-pyridone-5-carboxamide:a novel uremic toxin[J]Kidney International,2003,63:S19-S21.
[41] RUTKOWSKI B, RUTKOWSKI P, S?OMINSKA E,et al.Cellular toxicity of nicotinamide metabolites[J].Journal of Renal Nutrition,2012,22:95-97.

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