Effects of Mycotoxin on Intestinal Tight Junction Protein and Its Regulation Mechanism

  • YANG Xue ,
  • GAO Yanan ,
  • WANG Jiaqi ,
  • ZHENG Nan
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  • 1. Key Laboratory of Quality & Safety Control for Milk and Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Laboratory of Quality and Safety Risk Assessment for Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    3. Milk and Milk Products Inspection Center of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2020-04-26

  Online published: 2020-12-07

Abstract

Mycotoxin is a toxic secondary metabolite produced by Penicillium, Aspergillus and Fusarium, it has attracted wide attention because of its universal existence in all kinds of food and feed. At present, the risk assessment of mycotoxins is mainly focused on its nephrotoxicity, hepatotoxicity, immunotoxicity, genotoxicity and potential carcinogenicity. In recent years, the enterotoxicity of mycotoxin has been widely concerned by researchers. As an important part of the intestinal barrier, intestinal tight junction plays an important role in the enterotoxicity induced by mycotoxins. More and more studies have shown that there is a close relationship between intestinal tight junction injury and enterotoxicity. Different cell and animal experiments show that mycotoxins damage the integrity of intestinal barrier and induce enterotoxicity. In this paper, the damage effects of several major mycotoxins (zearalenone, fumonisin, aflatoxin, ochratoxin and deoxynivalenol) on tight junctions were systematically discussed in order to provide theoretical basis for the overall risk assessment of mycotoxins.

Cite this article

YANG Xue , GAO Yanan , WANG Jiaqi , ZHENG Nan . Effects of Mycotoxin on Intestinal Tight Junction Protein and Its Regulation Mechanism[J]. Chinese Journal of Animal Nutrition, 2020 , 32(12) : 5566 -5577 . DOI: 10.3969/j.issn.1006-267x.2020.12.010

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