[1] CAPRIOTTI A L,CARUSO G,CAVALIERE C,et al.Multiclass mycotoxin analysis in food,environmental and biological matrices with chromatography/mass spectrometry[J].Mass Spectrometry Reviews,2012,31(4):466-503.
[2] BENNETT J W,KLICH M.Mycotoxins[M]//SCHAECHTER M.Encyclopedia of Microbiology.3rd ed.Oxford:Elsevier Inc.,2009:559-565.
[3] ANFOSSI L,BAGGIANI C,GIOVANNOLI C,et al.Mycotoxins in food and feed:extraction,analysis and emerging technologies for rapid and on-field detection[J].Recent Patents on Food,Nutrition & Agriculture,2010,2(2):140-153.
[4] ALASSANE-KPEMBI I,SCHATZMAYR G,TARANU I,et al.Mycotoxins co-contamination:methodological aspects and biological relevance of combined toxicity studies[J].Critical Reviews in Food Science and Nutrition,2017,57(16):3489-3507.
[5] SINGH G M,MICHA R,KHATIBZADEH S,et al.Global,regional,and national consumption of sugar-sweetened beverages,fruit juices,and milk:a systematic assessment of beverage intake in 187 countries[J].PLoS One,2015,10(8):e0124845.
[6] HUSSEIN H S,BRASEL J M.Toxicity,metabolism,and impact of mycotoxins on humans and animals[J].Toxicology,2001,167(2):101-134.
[7] FINK-GREMMELS J.Mycotoxins in cattle feeds and carry-over to dairy milk:a review[J].Food Additives & Contaminants:Part A,2008,25(2):172-180.
[8] RODRIGUES I,NAEHRER K.A three-year survey on the worldwide occurrence of mycotoxins in feedstuffs and feed[J].Toxins,2012,4(9):663-765.
[9] GALLO A,GIUBERTI G,FRISVAD J C,et al.Review on mycotoxin issues in ruminants:occurrence in forages,effects of mycotoxin ingestion on health status and animal performance and practical strategies to counteract their negative effects[J].Toxins,2015,7(8):3057-3111.
[10] STROSNIDER H,AZZIZ-BAUMGARTNER E,BANZIGER M,et al.Workgroup report:public health strategies for reducing aflatoxin exposure in developing countries[J].Environmental Health Perspectives,2006,114(12):1898-1903.
[11] 郑楠,李松励,许晓敏,等.牛奶中霉菌毒素风险排序[J].中国畜牧兽医,2013,40(增刊):9-11. ZHENG N,LI S L,XU X M,et al.Risk ranking of mycotoxin in milk in China[J].China Animal Husbandry and Veterinary Medicine,2013,40(Suppl.):9-11.(in Chinese)
[12] FLORES-FLORES M E,LIZARRAGA E,DE CERAIN A L,et al.Presence of mycotoxins in animal milk:a review[J].Food Control,2015,53:163-176.
[13] ALVITO P C,SIZOO E A,ALMEIDA C M M,et al.Occurrence of aflatoxins and ochratoxin a in baby foods in portugal[J].Food Analytical Methods,2010,3(1):22-30.
[14] KABAK B.Aflatoxin M
1 and ochratoxin A in baby formulae in Turkey:occurrence and safety evaluation[J].Food Control,2012,26(1):182-187.
[15] UL HASSAN Z,AL THANI R,ATIA F A,et al.Co-occurrence of mycotoxins in commercial formula milk and cereal-based baby food on the Qatar market[J].Food Additives & Contaminants:Part B,2018,11(3):191-197.
[16] HUANG L C,ZHENG N,ZHENG B Q,et al.Simultaneous determination of aflatoxin m1,ochratoxin A,zearalenone and α-zearalenol in milk by UHPLC-MS/MS[J].Food Chemistry,2014,146:242-249.
[17] OLIVEIRA C A,ROSMANINHO J,ROSIM R.Aflatoxin M1 and cyclopiazonic acid in fluid milk traded in Sao Paulo,Brazil[J].Food Additives & Contaminants,2006,23(2):196-201.
[18] KOKKONEN M,JESTOI M,RIZZO A.Determination of selected mycotoxins in mould cheeses with liquid chromatography coupled to tandem with mass spectrometry[J].Food Additives & Contaminants,2005,22(5):449-456.
[19] FONTAINE K,PASSERÓ E,VALLONE L,et al.Occurrence of roquefortine C,mycophenolic acid and aflatoxin M
1 mycotoxins in blue-veined cheeses[J].Food Control,2015,47:634-640.
[20] 黄良策.牛奶中多霉菌毒素UPLC-MS/MS检测方法建立及其风险分析研究[D].硕士学位论文.合肥:安徽农业大学,2013. HUANG L C.Establishment of UPLC-MS/MS detection method for polymycotoxins in milk and its risk analysis[D].Master's Thesis.Hefei:Anhui Agricultural University,2013.(in Chinese)
[21] FICHEUX A S,SIBIRIL Y,PARENT-MASSIN D.Co-exposure of
Fusarium mycotoxins:
in vitro myelotoxicity assessment on human hematopoietic progenitors[J].Toxicon,2012,60(6):1171-1179.
[22] RUIZ M J,MACÁKOVÁP,JUAN-GARCÍA A,et al.Cytotoxic effects of mycotoxin combinations in mammalian kidney cells[J].Food and Chemical Toxicology,2011,49(10):2718-2724.
[23] AUPANUN S,PHUEKTES P,POAPOLATHEP S,et al.Individual and combined cytotoxicity of major trichothecenes type B,deoxynivalenol,nivalenol,and fusarenon-X on Jurkat human T cells[J].Toxicon,2019,160:29-37.
[24] HEUSSNER A H,DIETRICH D R,O'BRIEN E.
In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells[J].Toxicology in Vitro,2006,20(3):332-341.
[25] KLARI? M S,PEPELJNJAK S,DOMIJAN A M,et al.Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B
1,beauvericin and ochratoxin A[J].Basic & Clinical Pharmacology & Toxicology,2007,100(3):157-164.
[26] KLARI? M S,RUMORA L,LJUBANOVI? D,et al.Cytotoxicity and apoptosis induced by fumonisin B
1,beauvericin and ochratoxin A in porcine kidney PK15 cells:effects of individual and combined treatment[J].Archives of Toxicology,2008,82(4):247-255.
[27] KLARI? M S,?ELJE?I? D,RUMORA L,et al.A potential role of calcium in apoptosis and aberrant chromatin forms in porcine kidney PK15 cells induced by individual and combined ochratoxin A and citrinin[J].Archives of Toxicology,2012,86(1):97-107.
[28] GRENIER B,OSWALD I.Mycotoxin co-contamination of food and feed:meta-analysis of publications describing toxicological interactions[J].World Mycotoxin Journal,2011,4(3):285-313.
[29] BLISS C I.The toxicity of poisons applied jointly[J].Annals of Applied Biology,1939,26(3):585-615.
[30] CHOU T C,TALALAY P.Quantitative analysis of dose-effect relationships:the combined effects of multiple drugs or enzyme inhibitors[J].Advances in Enzyme Regulation,1984,22:27-55.
[31] CHOU T C.Theoretical basis,experimental design,and computerized simulation of synergism and antagonism in drug combination studies[J].Pharmacological Reviews,2006,58(3):621-681.
[32] WEBER F,FREUDINGER R,SCHWERDT G,et al.A rapid screening method to test apoptotic synergisms of ochratoxin A with other nephrotoxic substances[J].Toxicology in Vitro,2005,19(1):135-143.
[33] GROTEN J P,TAJIMA O,FERON V J,et al.Statistically designed experiments to screen chemical mixtures for possible interactions[J].Environmental Health Perspectives,1998,106(Suppl.6):1361-1365.
[34] KLARI? M Š.Adverse effects of combined mycotoxins[J].Archives of Industrial Hygiene and Toxicology,2012,63(4):519-530.
[35] TAMMER B,LEHMANN I,NIEBER K,et al.Combined effects of mycotoxin mixtures on human T cell function[J].Toxicology Letters,2007,170(2):124-133.
[36] QUINN B.Preparation and maintenance of live tissues and primary cultures for toxicity studies[M]//GAGNE F.Biochemical ecotoxicology.New York:Elsevier Academic Press Inc.,2014:33-47.
[37] HARTUNG T,DASTON G.Are
in vitro tests suitable for regulatory use?[J].Toxicological Sciences,2009,111(2):233-237.
[38] SMITH M C,MADEC S,COTON E,et al.Natural co-occurrence of mycotoxins in foods and feeds and their
in vitro combined toxicological effects[J].Toxins,2016,8(4):94.
[39] TAVARES A M,ALVITO P,LOUREIRO S,et al.Multi-mycotoxin determination in baby foods and
in vitro combined cytotoxic effects of aflatoxin M
1 and ochratoxin A[J].World Mycotoxin Journal,2013,6(4):375-388.
[40] HUANG X,GAO Y A,LI S L,et al.Modulation of mucin (
MUC2,
MUC5AC and
MUC5B) mRNA expression and protein production and secretion in Caco-2/HT29-MTX Co-cultures following exposure to individual and combined aflatoxin M
1 and ochratoxin A[J].Toxins,2019,11(2):132.
[41] GAO Y N,WANG J Q,LI S L,et al.Aflatoxin M
1 cytotoxicity against human intestinal Caco-2 cells is enhanced in the presence of other mycotoxins[J].Food and Chemical Toxicology,2016,96:79-89.
[42] ZHENG N,GAO Y N,LIU J,et al.Individual and combined cytotoxicity assessment of zearalenone with ochratoxin A or α-zearalenol by full factorial design[J].Food Science and Biotechnology,2017,27(1):251-259.
[43] SMITH M C,GHEUX A,COTON M,et al.
In vitro co-culture models to evaluate acute cytotoxicity of individual and combined mycotoxin exposures on Caco-2,THP-1 and HepaRG human cell lines[J].Chemico-Biological Interactions,2018,281:51-59.
[44] BENSASSI F,GALLERNE C,EL DEIN O S,et al.
In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone[J].Toxicon,2014,84:1-6.
[45] WAN L Y M,TURNER P C,EL-NEZAMI H.Individual and combined cytotoxic effects of Fusarium toxins (deoxynivalenol,nivalenol,zearalenone and fumonisins B
1) on swine jejunal epithelial cells[J].Food and Chemical Toxicology,2013,57:276-283.
[46] KOUADIO J H,DANO S D,MOUKHA S,et al.Effects of combinations of
Fusarium mycotoxins on the inhibition of macromolecular synthesis,malondialdehyde levels,DNA methylation and fragmentation,and viability in Caco-2 cells[J].Toxicon,2007,49(3):306-317.
[47] SIVAKUMAR G,DWIVEDI P,SHARMA A K,et al.Fumonisin B
1 and ochratoxin A induced biochemical changes in young male New Zealand white rabbits[J].Indian Journal of Veterinary Pathology,2009,30(1):30-34.
[48] STOEV S D,GUNDASHEVA D,ZARKOV I,et al.Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B
1[J].Experimental and Toxicologic Pathology,2012,64(7/8):733-741.
[49] REN Z H,DENG H D,WANG Y C,et al.The
Fusarium toxin zearalenone and deoxynivalenol affect murine splenic antioxidant functions,interferon levels,and T-cell subsets[J].Environmental Toxicology and Pharmacology,2016,41:195-200.
[50] LIANG Z,REN Z H,GAO S,et al.Individual and combined effects of deoxynivalenol and zearalenone on mouse kidney[J].Environmental Toxicology and Pharmacology,2015,40(3):686-691.
[51] SZABÓ-FODOR J,SZABÓ A,KÓCSÓ D,et al.Interaction between the three frequently co-ccurring
Fusarium mycotoxins in rats[J].Journal of Animal Physiology and Animal Nutrition,2019,103(1):370-382.
[52] KOUADIO J H,MOUKHA S,BROU K,et al.Lipid metabolism disorders,lymphocytes cells death,and renal toxicity induced by very low levels of deoxynivalenol and fumonisin B
1 alone or in combination following 7 days oral administration to mice[J].Toxicology International,2013,20(3):218-223.
[53] EL-NEKEETY A A,EL-KADY A A,ABDEL-WAHHAB K G,et al.Reduction of individual or combined toxicity of fumonisin B
1 and zearalenone via dietary inclusion of organo-modified nano-montmorillonite in rats[J].Environmental Science and Pollution Research,2017,24(25):20770-20783.
[54] TAJIMA O,SCHOEN E D,FERON V J,et al.Statistically designed experiments in a tiered approach to screen mixtures of
Fusarium mycotoxins for possible interactions[J].Food and Chemical Toxicology,2002,40(5):685-695.
[55] LUONGO D,SEVERINO L,BERGAMO P,et al.Interactive effects of fumonisin B
1 and α-zearalenol on proliferation and cytokine expression in Jurkat T cells[J].Toxicology in Vitro,2006,20(8):1403-1410.
[56] SEVERINO L,LUONGO D,BERGAMO P,et al.Mycotoxins nivalenol and deoxynivalenol differentially modulate cytokine mRNA expression in Jurkat T cells[J].Cytokine,2006,36(1/2):75-82.
[57] CHEN F,MA Y L,XUE C Y,et al.The combination of deoxynivalenol and zearalenone at permitted feed concentrations causes serious physiological effects in young pigs[J].Journal of Veterinary Science,2008,9(1):39-44.
[58] CORCUERA L A,ARBILLAGA L,VETTORAZZI A,et al.Ochratoxin A reduces aflatoxin B
1 induced DNA damage detected by the comet assay in Hep G2 cells[J].Food and Chemical Toxicology,2011,49(11):2883-2889.
[59] KOUADIO J H,MOBIO T A,BAUDRIMONT I,et al.Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol,zearalenone or fumonisin B
1 in human intestinal cell line Caco-2[J].Toxicology,2005,213(1/2):56-65.
[60] BOONE M D.Examining the single and interactive effects of three insecticides on amphibian metamorphosis[J].Environmental Toxicology and Chemistry,2008,27(7):1561-1568.
[61] CAVALIERE C,FOGLIA P,PASTORINI E,et al.Development of a multiresidue method for analysis of major
Fusarium mycotoxins in corn meal using liquid chromatography/tandem mass spectrometry[J].Rapid Communications in Mass Spectrometry,2005,19(14):2085-2093.
[62] SPEIJERS G J A,SPEIJERS M H M.Combined toxic effects of mycotoxins[J].Toxicology Letters,2004,153(1):91-98.
