XIA Yingying , ZOU Tiande , LI Shuo , YOU Jinming . Nutritional Physiology Function and Feeding Prospects of Quercetin[J]. Chinese Journal of Animal Nutrition, 2021 , 33(2) : 729 -736 . DOI: 10.3969/j.issn.1006-267x.2021.02.014

[1] DELRIO D,RODRIGUEZ-MATEOS A,SPENCER J P E,et al.Dietary (poly) phenolics in human health:structures,bioavailability,and evidence of protective effects against chronic diseases[J].Antioxidants & Redox Signaling,2013,18(14):1818-1892
[2] OZDAL Z D,SAHMETLIOGLU E,NARIN I,et al.Synthesis of gold and silver nanoparticles using flavonoid quercetin and their effects on lipopolysaccharide induced inflammatory response in microglial cells[J].3 Biotech,2019,9(6):212.
[3] SCALBERT A,WILLIAMSON G.Dietary intake and bioavailability of polyphenols[J].The Journal of Nutrition,2000,130(8):2073S-2085S.
[4] MANACH C,WILLIAMSON G,MORAND C,et al.Bioavailability and bioefficacy of polyphenols in humans.Ⅰ.Review of 97 bioavailability studies[J].The American Journal of Clinical Nutrition,2005,81(1):230S-242S.
[5] FORMICA J V,REGELSON W.Review of the biology of quercetin and related bioflavonoids[J].Food & Chemical Toxicology,1995,33(12):1061-1080.  
[6] AVINASH B,VENU R,PRASAD T,et al.Synthesis and characterisation of neem leaf extract,2,3-dehydrosalanol and quercetin dihydrate mediated silver nano particles for therapeutic applications[J].IET Nanobiotechnology,2017,11(4):383-389.  
[7] TOREL J,CILLARD J,CILLARD P.Antioxidant activity of flavonoids and reactivity with peroxy radical[J].Phytochemistry,1986,25(2):383-385.  
[8] XU D,HU M J,WANG Y Q,et al.Antioxidant activities of quercetin and its complexes for medicinal application[J].Molecules,2019,24(6):1123.
[9] AHMED O M,AHMED A A,FAHIM H I,et al.Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats:the roles of oxidative stress,inflammation and cell apoptosis[J].Drug and Chemical Toxicology,2019,doi:10.1080/01480545.2019.1683187.
[10] DONG Y Y,HOU Q H,LEI J Q,et al.Quercetin alleviates intestinal oxidative damage induced by H₂O₂ via modulation of GSH:in vitro screening and in vivo evaluation in a colitis model of mice[J].ACS Omega,2020,5(14):8334-8346.  
[11] RUBIO-RUIZ M E,GUARNER-LANS V,CANO-MARTÍNEZ A,et al.Resveratrol and quercetin administration improves antioxidant defenses and reduces fatty liver in metabolic syndrome rats[J].Molecules,2019,24(7):1297.
[12] TKACZ K,WOJDYŁO A,TURKIEWICZ I P,et al.UPLC-PDA-Q/TOF-MS profiling of phenolic and carotenoid compounds and their influence on anticholinergic potential for AChE and BuChE inhibition and on-line antioxidant activity of selected Hippophaë rhamnoides L. cultivars[J].Food Chemistry,2020,309:125766.
[13] ADEDARA I A,EGO V C,SUBAIR T I,et al.Quercetin improves neurobehavioral performance through restoration of brain antioxidant status and acetylcholinesterase activity in manganese-treated rats[J].Neurochemical Research,2017,42(4):1219-1229.  
[14] MENG L Q,YANG F Y,WANG M S,et al.Quercetin protects against chronic prostatitis in rat model through NF-κB and MAPK signaling pathways[J].The Prostate,2018,78(11):790-800.  
[15] ZHAO Y,HU X B,LIU Y J,et al.ROS signaling under metabolic stress:cross-talk between AMPK and AKT pathway[J].Molecular Cancer,2017,16(1):79.
[16] HANIKOGLU A,KUCUKSAYAN E,HANIKOGLU F,et al.Effects of somatostatin,curcumin,and quercetin on the fatty acid profile of breast cancer cell membranes[J].Canadian Journal of Physiology and Pharmacology,2020,98(3):131-138.  
[17] KAWAMURA K,QI F,KOBAYASHI J.Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production[J].Journal of Radiation Research,2018,59(Suppl.2):ii91-ii97.
[18] ZARAGOZÁ C,VILLAESCUSA L,MONSERRAT J,et al.Potential therapeutic anti-inflammatory and immunomodulatory effects of dihydroflavones,flavones,and flavonols[J].Molecules,2020,25(4):1017.
[19] LU H,WU L F,LIU L P,et al.Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization[J].Biochemical Pharmacology,2018,154:203-212.
[20] MARUTHAMUTHU V,HENRY L J K,RAMAR M K,et al.Myxopyrum serratulum ameliorates airway inflammation in LPS-stimulated RAW 264.7 macrophages and OVA-induced murine model of allergic asthma[J].Journal of Ethnopharmacology,2020,255:112369.
[21] CUI S N,WU Q Q,WANG J,et al.Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton[J].Cell Adhesion & Migration,2019,13(1):1-12.  
[22] NANI B D,DE CÁSSIA ORLANDI SARDI J,LAZARINI J G,et al.Anti-inflammatory and anti-Candida effects of Brazilian organic propolis,a promising source of bioactive molecules and functional food[J].Journal of Agricultural and Food Chemistry,2020,68(10):2861-2871.  
[23] HUANG R Y,YU Y L,CHENG W C,et al.Immunosuppressive effect of quercetin on dendritic cell activation and function[J].The Journal of Immunology,2010,184(12):6815-6821.  
[24] LI Y,XIA H L,WU M Q,et al.Evaluation of the antibacterial effects of flavonoid combination from the leaves of Dracontomelon dao by microcalorimetry and the quadratic rotary combination design[J].Frontiers in Pharmacology,2017,8:70.
[25] SHIN J E,KIM J M,BAE E A,et al.In vitro inhibitory effect of flavonoids on growth,infection and vacuolation of Helicobacter pylori[J].Planta Medica,2005,71(3):197-201.  
[26] GONZÁLEZ-SEGOVIA R,QUINTANAR J L,SALINAS E,et al.Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig[J].Journal of Gastroenterology,2008,43(6):441-447.  
[27] METO A,COLOMBARI B,METO A,et al.Propolis affects Pseudomonas aeruginosa growth,biofilm formation,eDNA release and phenazine production:potential involvement of polyphenols[J].Microorganisms,2020,8(2):243.
[28] POURTEYMOUR FARD TABRIZI F,HAJIZADEH-SHARAFABAD F,VAEZI M,et al.Quercetin and polycystic ovary syndrome,current evidence and future directions:a systematic review[J].Journal of Ovarian Research,2020,13(1):11.
[29] YING L L,CHAUDHRY M T,XIAO F L,et al.The effects and mechanism of quercetin dietary supplementation in streptozotocin-induced hyperglycemic arbor acre broilers[J].Oxidative Medicine and Cellular Longevity,2020,2020:9585047.
[30] FORNEY L A,LENARD N R,STEWART L K,et al.Dietary quercetin attenuates adipose tissue expansion and inflammation and alters adipocyte morphology in a tissue-specific manner[J].International Journal of Molecular Sciences,2018,19(3):895.
[31] JEFFERY E,WING A,HOLTRUP B,et al.The adipose tissue microenvironment regulates depot-specific adipogenesis in obesity[J].Cell Metabolism,2016,24(1):142-150.  
[32] HSU C L,YEN G C.Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity[J].Molecular Nutrition & Food Research,2006,50(11):1072-1079.  
[33] AHN J,LEE H,KIM S,et al.The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways[J].Biochemical and Biophysical Research Communications,2008,373(4):545-549.  
[34] GONZALES A M,ORLANDO R A.Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy[J].Nutrition & Metabolism,2007,4(1):22.
[35] LIN Y,YANG N,BAO B,et al.Luteolin reduces fat storage in Caenorhabditis elegans by promoting the central serotonin pathway[J].Food & Function,2020,11(1):730-740.  
[36] CASTALDO L,NARVÁEZ A,IZZO L,et al.Red wine consumption and cardiovascular health[J].Molecules,2019,24(19):3626.
[37] YAMAGATA K.Polyphenols regulate endothelial functions and reduce the risk of cardiovascular disease[J].Current Pharmaceutical Design,2019,25(22):2443-2458.  
[38] DABEEK W M,MARRA M V.Dietary quercetin and kaempferol:bioavailability and potential cardiovascular-related bioactivity in humans[J].Nutrients,2019,11(10):2288.
[39] HAZAFA A,KHALIL-UR-REHMAN,JAHAN N,et al.The role of polyphenol (flavonoids) compounds in the treatment of cancer cells[J].Nutrition and Cancer,2020,72(3):386-397.  
[40] ZOU Y,WEI H K,XIANG Q H,et al.Protective effect of quercetin on pig intestinal integrity after transport stress is associated with regulation oxidative status and inflammation[J].Journal of Veterinary Medical Science,2016,78(9):1487-1494.  
[41] ZHANG C C,KANG K,NING P B,et al.Heat shock protein 70 is associated with CSFV NS5A protein and enhances viral RNA replication[J].Virology,2015,482:9-18.
[42] SANTINI S E,BASINI G,BUSSOLATI S,et al.The phytoestrogen quercetin impairs steroidogenesis and angiogenesis in swine granulosa cells in vitro[J].BioMed Research International,2009,2009:419891.
[43] SUN L,XU G Q,DONG Y Y Y,et al.Quercetin protects against lipopolysaccharide-induced intestinal oxidative stress in broiler chickens through activation of Nrf2 pathway[J].Molecules,2020,25(5):1053.
[44] SOHAIB M,BUTT MS,SHABBIR MA,et al.Lipid stability,antioxidant potential and fatty acid composition of broilers breast meat as influenced by quercetin in combination with α-tocopherol enriched diets[J].Lipids in Health and Disease,2015,14(1):61.
[45] GOLIOMYTIS M,TSOUREKI D,SIMITZIS P E,et al.The effects of quercetin dietary supplementation on broiler growth performance,meat quality,and oxidative stability[J].Poultry Science,2014,93(8):1957-1962.  
[46] YANG J X,MARIA T C,ZHOU B,et al.Quercetin improves immune function in Arbor Acre broilers through activation of NF-κB signaling pathway[J].Poultry Science,2020,99(2):906-913.  
[47] LIU Y,LI Y,LIU H N,et al.Effect of quercetin on performance and egg quality during the late laying period of hens[J].British Poultry Science,2013,54(4):510-514.  
[48] LIU H N,LIU Y,HU L L,et al.Effects of dietary supplementation of quercetin on performance,egg quality,cecal microflora populations,and antioxidant status in laying hens[J].Poultry Science,2014,93(2):347-353.  
[49] ISKENDER H,YENICE G,DOKUMACIOGLU E,et al.Comparison of the effects of dietary supplementation of flavonoids on laying hen performance,egg quality and egg nutrient profile[J].British Poultry Science,2017,58(5):550-556.  
[50] GHANIEI A,ESLAMI M,ZADEH HASHEM E,et al.Quercetin attenuates H₂O₂-induced toxicity of rooster semen during liquid storage at 4℃[J].Journal of Animal Physiology and Animal Nutrition,2019,103(3):713-722.  
[51] BHUTTO Z A,HE F,ZLOH M,et al.Use of quercetin in animal feed:effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken[J].Scientific Reports,2018,8(1):4400.
[52] KEHRLI M,Jr,NEILL J,BURVENICH C,et al.Energy and protein effects on the immune system[C]//Proceedings of the 10th international symposium on ruminant physiology.Copenhagen,Denmark:Wageningen Academic Publishers,2006:455-471.
[53] STOLDT A K,MIELENZ M,NÜRNBERG G,et al.Effects of a six-week intraduodenal supplementation with quercetin on liver lipid metabolism and oxidative stress in peripartal dairy cows[J].Journal of Animal Science,2016,94(5):1913-1923.  
[54] SILVA A A A,SILVA M N P,FIGUEIREDO L B F,et al.Quercetin influences in vitro maturation,apoptosis and metabolically active mitochondria of goat oocytes[J].Zygote,2018,26(6):465-470.  
[55] STOLDT A K,DERNO M,DAS G,et al.Effects of rutin and buckwheat seeds on energy metabolism and methane production in dairy cows[J].Journal of Dairy Science,2016,99(3):2161-2168.  
[56] BERGER L M,BLANK R,ZORN F,et al.Ruminal degradation of quercetin and its influence on fermentation in ruminants[J].Journal of Dairy Science,2015,98(8):5688-5698.