Research Progress of Polyphenols in Piglet Iron Supply Imbalance

  • DING Haoxuan ,
  • ZHAO Yang ,
  • HONG Zuopeng ,
  • FENG Jie
Expand
  • Zhejiang Key Laboratory of Animal Nutrition, Institute of Feed Science, Zhejiang University, Hangzhou 310058, China

Received date: 2020-07-16

  Online published: 2021-03-18

Supported by

 

Abstract

Iron is one of the essential trace elements for piglet growth and development. Iron deficiency leading to piglet anemia is an important factor affecting piglet growth and development, and iron overload can also cause piglet oxidative stress through Fenton reaction. Finding highly effective antioxidants that can interfere with iron deficiency and iron overload damage has become a rising hot research topic. As natural plant-derived antioxidants, polyphenolic compounds have high antioxidant activity, metal chelating ability, anti-inflammatory and bacteriostatic functions, and can play a good intervention effect in the iron deficiency and overload of livestock and poultry. Therefore, this article reviews the research progress of polyphenols in pigs with iron deficiency and iron overload, and aims to provide a reference for the intervention of polyphenols in the disturbance of trace element metabolism in livestock and poultry.

Cite this article

DING Haoxuan , ZHAO Yang , HONG Zuopeng , FENG Jie . Research Progress of Polyphenols in Piglet Iron Supply Imbalance[J]. Chinese Journal of Animal Nutrition, 2021 , 33(3) : 1223 -1229 . DOI: 10.3969/j.issn.1006-267x.2021.03.004

References

[1] LIPIŃSKI P,STARZYŃSKI R R,CANONNE-HERGAUX F,et al.Benefits and risks of iron supplementation in anemic neonatal pigs[J].The American Journal of Pathology,2010,177(3):1233-1243.  
[2] IMAM M U,ZHANG S S,MA J F,et al.Antioxidants mediate both iron homeostasis and oxidative stress[J].Nutrients,2017,9(7):671.
[3] CHEN X Y,ZHANG X F,ZHAO J,et al.Split iron supplementation is beneficial for newborn piglets[J].Biomedicine & Pharmacotherapy,2019,120:109479.
[4] National Research Council.Nutrient requirements of swine[S].11th ed.Washington,D.C.:National Academies Press,2012.
[5] 马雪莲,张丽阳,王良治,等.我国畜禽饲料资源中微量元素铁含量分布的调查研究[J].动物营养学报,2019,31(8):3821-3829. MA X L,ZHANG L Y,WANG L Z,et al.A survey on distribution of iron content in feedstuff resources for livestock and poultry in China[J].Chinese Journal of Animal Nutrition,2019,31(8):3821-3829.(in Chinese)
[6] 马雪莲,廖秀冬,张丽阳,等.铁水平和孵育时间对原代培养肉鸡鸡胚肝细胞中铁含量及含铁酶活性、基因表达和蛋白表达的影响[J].动物营养学报,2020,32(8):3830-3842. MA X L, LIAO X D, ZHANG L Y,et al.Effects of iron level and incubation time on iron content and activity, gene expression and protein expression of iron-containing enzyme in primarily cultured hepatocytes of broiler embryos[J].Chinese Journal of Animal Nutrition,2020,32(8):3830-3842.(in Chinese)
[7] QI X,ZHANG Y X,GUO H,et al.Mechanism and intervention measures of iron side effects on the intestine[J].Critical Reviews in Food Science and Nutrition,2020,60(12):2113-2125.  
[8] BASU T,PANJA S,SHENDGE A K,et al.A natural antioxidant,tannic acid mitigates iron-overload induced hepatotoxicity in Swiss albino mice through ROS regulation[J].Environmental Toxicology,2018,33(5):603-618.  
[9] VENN J A J,MCCANCE R A,WIDDOWSON E M.Iron metabolism in piglet anaemia[J].Journal of Comparative Pathology and Therapeutics,1947,57:314-325.
[10] LIAO Y L,LOPEZ V,SHAFIZADEH T B,et al.Cloning of a pig homologue of the human lactoferrin receptor:expression and localization during intestinal maturation in piglets[J].Comparative Biochemistry and Physiology Part A:Molecular & Integrative Physiology,2007,148(3):584-590.  
[11] DIXON S J,STOCKWELL B R.The role of iron and reactive oxygen species in cell death[J].Nature Chemical Biology,2014,10(1):9-17.  
[12] LI Y H,HANSEN S L,BORST L B,et al.Dietary Iron deficiency and oversupplementation increase intestinal permeability,ion transport,and inflammation in pigs[J].The Journal of Nutrition,2016,146(8):1499-1505.  
[13] JI P,NONNECKE E B,DOAN N,et al.Excess iron enhances purine catabolism through activation of xanthine oxidase and impairs myelination in the hippocampus of nursing piglets[J].The Journal of Nutrition,2019,149(11):1911-1919.  
[14] ESPINOZA A,MORALES S,ARREDONDO M.Effects of acute dietary iron overload in pigs (Sus scrofa) with induced type 2 diabetes mellitus[J].Biological Trace Element Research,2014,158(3):342-352.  
[15] DING H X,CAO A Z,LI H Y,et al.Effects of Eucommia ulmoides leaf extracts on growth performance,antioxidant capacity and intestinal function in weaned piglets[J].Journal of Animal Physiology and Animal Nutrition,2020,104(4):1169-1177,doi:10.1111/jpn.13333.
[16] 毋囡囡,林雪纯,应晨江,等.多酚类化合物与必需微量元素的相互作用[J].卫生研究,2019,48(6):1012-1016. WU N N,LIN X C,YING C J,et al.Interaction of polyphenols with essential trace elements[J].Journal of Hygiene Research,2019,48(6):1012-1016.(In Chinese)
[17] GESSNER D K,RINGSEIS R,EDER K.Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals[J].Journal of Animal Physiology and Animal Nutrition,2017,101(4):605-628.  
[18] MANACH C,SCALBERT A,MORAND C,et al.Polyphenols:food sources and bioavailability[J].The American Journal of Clinical Nutrition,2004,79(5):727-747.  
[19] VAIDYANATHAN J B,WALLE T.Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes[J].Drug Metabolism and Disposition,2002,30(8):897-903.  
[20] CARDONA F,ANDRÉS-LACUEVA C,TULIPANI S,et al.Benefits of polyphenols on gut microbiota and implications in human health[J].The Journal of Nutritional Biochemistry,2013,24(8):1415-1422.  
[21] MARGALEF M,PONS Z,IGLESIAS-CARRES L,et al.Gender-related similarities and differences in the body distribution of grape seed flavanols in rats[J].Molecular Nutrition & Food Research,2016,60(4):760-772.  
[22] RAZA A,XU X Q,XIA L,et al.Quercetin-iron complex:synthesis,characterization,antioxidant,DNA binding,DNA cleavage,and antibacterial activity studies[J].Journal of Fluorescence,2016,26(6):2023-2031.  
[23] 闫昭明,郭秋平,仲银召,等.茶多酚的生物学特性及其在畜牧生产中的应用[J].动物营养学报,2019,31(4):1525-1532. YAN Z M,GUO Q P,ZHONG Y Z,et al.Tea polyphenols functions and their application in animal production[J].Chinese Journal of Animal Nutrition,2019,31(4):1525-1532.(in Chinese)
[24] QUESADA I M,BUSTOS M,BLAY M,et al.Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells[J].The Journal of Nutritional Biochemistry,2011,22(2):153-163.  
[25] ROBINSON K E,SHAH V H.Pathogenesis and pathways:nonalcoholic fatty liver disease & alcoholic liver disease[J].Translational Gastroenterology and Hepatology,2020,5:49.
[26] BI M X,DU X X,JIAO Q,et al.α-Synuclein regulates iron homeostasis via preventing parkin-mediated DMT1 ubiquitylation in Parkinson's disease models[J].ACS Chemical Neuroscience,2020,11(11):1682-1691,doi:10.1021/acschemneuro.0c00196.
[27] HORNIBLOW R D,HENESY D,IQBAL T H,et al.Modulation of iron transport,metabolism and reactive oxygen status by quercetin-iron complexes in vitro[J].Molecular Nutrition & Food Research,2017,61(3):1600692.
[28] MANDEL S A,AMIT T,KALFON L,et al.Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols:special reference to epigallocatechin gallate (EGCG)[J].Journal of Alzheimer's Disease,2008,15(2):211-222.  
[29] KONTOGHIORGHE C N,KOLNAGOU A,KONTOGHIORGHES G J.Phytochelators intended for clinical use in iron overload,other diseases of iron imbalance and free radical pathology[J].Molecules,2015,20(11):20841-20872.  
[30] MU M D,AN P,WU Q,et al.The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression[J].The Journal of Nutritional Biochemistry,2016,30:53-61.
[31] ZHEN A W,NGUYEN N H,GIBERT Y,et al.The small molecule,genistein,increases hepcidin expression in human hepatocytes[J].Hepatology,2013,58(4):1315-1325.  
[32] NIU Q,MU L T,LI S G,et al.Proanthocyanidin protects human embryo hepatocytes from fluoride-induced oxidative stress by regulating iron metabolism[J].Biological Trace Element Research,2016,169(2):174-179.  
[33] WONGJAIKAM S,KUMFU S,KHAMSEEKAEW J,et al.Combined iron chelator and antioxidant exerted greater efficacy on cardioprotection than monotherapy in iron-overloaded rats[J].PLoS One,2016,11(7):e0159414.
[34] SHIN J H,JEON H J,PARK J,et al.Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2[J].International Journal of Molecular Medicine,2016,38(4):1075-1082.  
[35] 贺宇佳,刘明,伍树松.植物多酚对氧化应激与炎症信号通路的调控机制[J].动物营养学报,2019,31(4):1554-1563. HE Y J,LIU M,WU S S.Regulation mechanism of plant polyphenols in oxidative stress and inflammatory signaling pathways[J].Chinese Journal of Animal Nutrition,2019,31(4):1554-1563.(in Chinese)
[36] FLEURY C,MIGNOTTE B,VAYSSIERE J L.Mitochondrial reactive oxygen species in cell death signaling[J].Biochimie,2002,84(2/3):131-141.
[37] ROSSI Y E,BOHL L P,VANDEN BRABER N L,et al.Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells.Studies of cytotoxicity,cytoprotection and interaction with ROS[J].Journal of Functional Foods,2020,67:103862.
[38] TATE P S,MARAZITA M C,MARQUIONI-RAMELLA M D,et al.Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells[J].Journal of Functional Foods,2020,67:103833.
[39] 郑红梅,王少英,史新娥.植物多酚的抗氧化作用及其改善肉质的机制[J].动物营养学报,2020,32(5):2037-2045. ZHENG H M,WANG S Y,SHI X E.Antioxidative effects of plant polyphenols and its mechanism of improving meat quality[J].Chinese Journal of Animal Nutrition,2020,32(5):2037-2045.(in Chinese)
[40] HALLIWELL B.Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?[J].Archives of Biochemistry and Biophysics,2008,476(2):107-112.  
[41] LEÓN-GONZÁLEZ A J,AUGER C,SCHINI-KERTH V B.Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy[J].Biochemical Pharmacology,2015,98(3):371-380.  
[42] LEE S H,SHINDE P L,CHOI J Y,et al.Effects of tannic acid supplementation on growth performance,blood hematology,iron status and faecal microflora in weanling pigs[J].Livestock Science,2010,131(2/3):281-286.
[43] BRUINS M J,VENTE-SPREEUWENBERG M A M,SMITS C H,et al.Black tea reduces diarrhoea prevalence but decreases growth performance in enterotoxigenic Escherichia coli-infected post-weaning piglets[J].Journal of Animal Physiology and Animal Nutrition,2011,95(3):388-398.  
[44] DONG J W,ZHOU Y Q,LU Y H,et al.Effect of tea polyphenols on the oxidation and color stability of porcine hemoglobin[J].Journal of Food Science,2019,84(8):2086-2090.  
[45] ÖZALP ÖZEN B,EREN M,PALA A,et al.Effect of plant extracts on lipid oxidation during frozen storage of minced fish muscle[J].International Journal of Food Science & Technology,2011,46(4):724-731.  
Outlines

/