[1] RODRIGUES I,NAEHRER K.A three-year survey on the worldwide occurrence of mycotoxins in feedstuffs and feed[J].Toxins,2012,4(9):663-675.
[2] YANG X,GAO J,LIU Q,et al.Co-occurrence of mycotoxins in maize and maize-derived food in China and estimation of dietary intake[J].Food Additives & Contaminants:Part B,2019,12(2):124-134.
[3] GEREZ J R,PINTON P,CALLU P,et al.Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs[J].Experimental and Toxicologic Pathology,2015,67(2):89-98.
[4] LIAO Y X,PENG Z,CHEN L K,et al.Deoxynivalenol,gut microbiota and immunotoxicity:a potential approach?[J].Food and Chemical Toxicology,2018,112:342-354.
[5] WU Q H,WANG X,YANG W,et al.Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans:an update[J].Archives of Toxicology,2014,88(7):1309-1326.
[6] BONNET M S,ROUX J,MOUNIEN L,et al.Advances in deoxynivalenol toxicity mechanisms:the brain as a target[J].Toxins,2012,4(11):1120-1138.
[7] TRENHOLM H L,HAMILTON R M,FRIEND D W,et al.Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat:effects on swine,poultry,and dairy cattle[J].Journal of the American Veterinary Medical Association,1984,185(5):527-531.
[8] ABBAS H K,MIROCHA C J,TUITE J.Natural occurrence of deoxynivalenol,15-acetyl-deoxynivalenol,and zearalenone in refusal factor corn stored since 1972[J].Applied and Environmental Microbiology,1986,51(4):841-843.
[9] ANDRETTA I,KIPPER M,LEHNEN C R,et al.Meta-analytical study of productive and nutritional interactions of mycotoxins in growing pigs[J].Animal,2012,6(9):1476-1482.
[10] CHAN H M,SHIN S Y,KIM B G.Aflatoxin,deoxynivalenol,and zearalenone in swine diets:predictions on growth performance[J].Revista Colombiana De Ciencias Pecuarias,2013,26(3):243-254.
[11] WANG S,YANG J C,ZHANG B Y,et al.Deoxynivalenol impairs porcine intestinal host defense peptide expression in weaned piglets and IPEC-J2 cells[J].Toxins,2018,10(12):541.
[12] ARNOLD D L,KARPINSKI K F,MCGUIRE P F,et al.A short-term feeding study with deoxynivalenol (vomitoxin) using rats[J].Fundamental and Applied Toxicology,1986,6(4):691-696.
[13] ROBBANA-BARNAT S,LORIDON-ROSA B,COHEN H,et al.Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingestion in mice[J].Food Additives & Contaminants,1987,4(1):49-56.
[14] LIN R Q,SUN Y,MU P Q,et al.
Lactobacillus rhamnosus GG supplementation modulates the gut microbiota to promote butyrate production,protecting against deoxynivalenol exposure in nude mice[J].Biochemical Pharmacology,2020,175:113868.
[15] FLANNERY B M,WU W D,PESTKA J J.Characterization of deoxynivalenol-induced anorexia using mouse bioassay[J].Food and Chemical Toxicology,2011,49(8):1863-1869.
[16] JIA H,WU W D,LU X,et al.Role of glucagon-like peptide-1 and gastric inhibitory peptide in anorexia induction following oral exposure to the trichothecene mycotoxin deoxynivalenol (vomitoxin)[J].Toxicological Sciences,2017,159(1):16-24.
[17] TOMINAGA M,MOMONAKA Y,YOKOSE C,et al.Anorexic action of deoxynivalenol in hypothalamus and intestine[J].Toxicon,2016,118:54-60.
[18] VESONDER R F,CIEGLER A,JENSEN A H.Isolation of the emetic principle from fusarium-infected corn[J].Applied Microbiology,1973,26(6):1008-1010.
[19] PESTKA J J.Deoxynivalenol-induced proinflammatory gene expression:mechanisms and pathological sequelae[J].Toxins,2010,2(6):1300-1317.
[20] PESTKA J J,SMOLINSKI A T.Deoxynivalenol:toxicology and potential effects on humans[J].Journal of Toxicology and Environmental Health:Part B,2005,8(1):39-69.
[21] FORSYTH D M,YOSHIZAWA T,MOROOKA N,et al.Emetic and refusal activity of deoxynivalenol to swine[J].Applied and Environmental Microbiology,1977,34(5):547-552.
[22] PRELUSKY D B,TRENHOLM H L.The efficacy of various classes of anti-emetics in preventing deoxynivalenol-induced vomiting in swine[J].Natural Toxins,1993,1(5):296-302.
[23] YOUNG L G,MCGIRR L,VALLI V E,et al.Vomitoxin in corn fed to young pigs[J].Journal of Animal Science,1983,57(3):655-664.
[24] SCHWARTZ M W.Central nervous system regulation of food intake[J].Obesity,2006,14(S2):1S-8S.
[25] HUSSAIN S S,BLOOM S R.The regulation of food intake by the gut-brain axis:implications for obesity[J].International Journal of Obesity,2013,37(5):625-633.
[26] PESTKA J J,ISLAM Z,AMUZIE C J.Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse[J].Toxicology Letters,2008,178(2):83-87.
[27] KOBAYASHI-HATTORI K,AMUZIE C J,FLANNERY B M,et al.Body composition and hormonal effects following exposure to mycotoxin deoxynivalenol in the high-fat diet-induced obese mouse[J].Molecular Nutrition & Food Research,2011,55(7):1070-1078.
[28] WANG S,YANG J C,ZHANG B Y,et al.Potential link between gut microbiota and deoxynivalenol-induced feed refusal in weaned piglets[J].Journal of Agricultural and Food Chemistry,2019,67(17):4976-4986.
[29] HEISLER L K,JOBST E E,SUTTON G M,et al.Serotonin reciprocally regulates melanocortin neurons to modulate food intake[J].Neuron,2006,51(2):239-249.
[30] FITZPATRICK D W,BOYD K E,WATTS B M.Comparison of the trichothecenes deoxynivalenol and T-2 toxin for their effects on brain biogenic monoamines in the rat[J].Toxicology Letters,1988,40(3):241-245.
[31] PRELUSKY D B,YEUNG J M,THOMPSON B K,et al.Effect of deoxynivalenol on neurotransmitters in discrete regions of swine brain[J].Archives of Environmental Contamination and Toxicology,1992,22(1):36-40.
[32] WU W D,BATES M A,BURSIAN S J,et al.Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin)[J].Toxicological Sciences,2013,133(1):186-195.
[33] WU W D,ZHOU H R,BURSIAN S J,et al.Calcium-sensing receptor and transient receptor ankyrin-1 mediate emesis induction by deoxynivalenol (vomitoxin)[J].Toxicological Sciences,2017,155(1):32-42.
[34] PRELUSKY D B.The effect of deoxynivalenol on serotoninergic neurotransmitter levels in pig blood[J].Journal of Environmental Science and Health,Part B,1994,29(6):1203-1218.
[35] CHEN L K,PENG Z,NÜSSLER A K,et al.Current and prospective sights in mechanism of deoxynivalenol-induced emesis for future scientific study and clinical treatment[J].Journal of Applied Toxicology,2017,37(7):784-791.
[36] LAM D D,PRZYDZIAL M J,RIDLEY S H,et al.Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors[J].Endocrinology,2008,149(3):1323-1328.
[37] TILIGADA E,WILSON J F.Regulation of α-melanocyte-stimulating hormone release from superfused slices of rat hypothalamus by serotonin and the interaction of serotonin with the dopaminergic system inhibiting peptide release[J].Brain Research,1989,503(2):225-228.
[38] SOHN J W,XU Y,JONES J E,et al.Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels[J].Neuron,2011,71(3):488-497.
[39] POSOVSZKY C,WABITSCH M.Regulation of appetite,satiation,and body weight by enteroendocrine cells.Part 1:characteristics of enteroendocrine cells and their capability of weight regulation[J].Hormone Research in Paediatrics,2015,83:1-10.
[40] TERCIOLO C,MARESCA M,PINTON P,et al.Review article:role of satiety hormones in anorexia induction by trichothecene mycotoxins[J].Food and Chemical Toxicology,2018,121:701-714.
[41] FLANNERY B M,CLARK E S,PESTKA J J.Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY[J].Toxicological Sciences,2012,130(2):289-297.
[42] CLARK E S,FLANNERY B M,GARDNER E M,et al.High sensitivity of aged mice to deoxynivalenol (vomitoxin)-induced anorexia corresponds to elevated proinflammatory cytokine and satiety hormone responses[J].Toxins,2015,7(10):4199-4215.
[43] WU W D,ZHOU H R,HE K Y,et al.Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol,15-acetyldeoxynivalenol,3-acetyldeoxynivalenol,fusarenon X,and nivalenol[J].Toxicological Sciences,2014,138(2):278-289.
[44] ZHOU H R,PESTKA J J.Deoxynivalenol (vomitoxin)-induced cholecystokinin and glucagon-like peptide-1 release in the STC-1 enteroendocrine cell model is mediated by calcium-sensing receptor and transient receptor potential ankyrin-1 channel[J].Toxicological Sciences,2015,145(2):407-417.
[45] MILLINGTON G W M.The role of proopiomelanocortin (POMC) neurones in feeding behaviour[J].Nutrition & Metabolism,2007,4:18.
[46] WU W D,ZHOU H R,PESTKA J J.Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1(TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin)[J].Archives of Toxicology,2017,91(1):495-507.
[47] CHALLIS B G,PINNOCK S B,COLL A P,et al.Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse[J].Biochemical and Biophysical Research Communications,2003,311(4):915-919.
[48] LI R N,LI Y S,SU Y T,et al.Short-term ingestion of deoxynivalenol in naturally contaminated feed alters piglet performance and gut hormone secretion[J].Animal Science Journal,2018,89(8):1134-1143.
[49] DANTZER R.Cytokine-induced sickness behavior:mechanisms and implications[J].Annals of the New York Academy of Sciences,2001,933(1):222-234.
[50] TARDIVEL C,AIRAULT C,DJELLOUL M,et al.The food born mycotoxin deoxynivalenol induces low-grade inflammation in mice in the absence of observed-adverse effects[J].Toxicology Letters,2015,232(3):601-611.
[51] ISLAM M R,ROH Y S,KIM J,et al.Differential immune modulation by deoxynivalenol (vomitoxin) in mice[J].Toxicology Letters,2013,221(2):152-163.
[52] WU W D,ZHANG H B.Role of tumor necrosis factor-α and interleukin-1β in anorexia induction following oral exposure to the trichothecene deoxynivalenol (vomitoxin) in the mouse[J].Journal of Toxicological Sciences,2014,39(6):875-886.
[53] JANG P G,NAMKOONG C,KANG G M,et al.NF-κB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia[J].Journal of Biological Chemistry,2010,285(13):9706-9715.
[54] ALCOCK J,MALEY C C,AKTIPIS C A.Is eating behavior manipulated by the gastrointestinal microbiota?Evolutionary pressures and potential mechanisms[J].Bioessays,2014,36(10):940-949.
[55] LEE W J,HASE K.Gut microbiota-generated metabolites in animal health and disease[J].Nature Chemical Biology,2014,10(6):416-424.
[56] VIGNAL C,DJOUINA M,PICHAVANT M,et al.Chronic ingestion of deoxynivalenol at human dietary levels impairs intestinal homeostasis and gut microbiota in mice[J].Archives of Toxicology,2018,92(7):2327-2338.
[57] LIU M,ZHANG L,CHU X H,et al.Effects of deoxynivalenol on the porcine growth performance and intestinal microbiota and potential remediation by a modified HSCAS binder[J].Food and Chemical Toxicology,2020,141:111373.
[58] WANG J J,ZHANG R Q,ZHAI Q Y,et al.Metagenomic analysis of gut microbiota alteration in a mouse model exposed to mycotoxin deoxynivalenol[J].Toxicology and Applied Pharmacology,2019,372:47-56.
[59] PENG Z,LIAO Y X,CHEN L K,et al.Heme oxygenase-1 attenuates low-dose of deoxynivalenol-induced liver inflammation potentially associating with microbiota[J].Toxicology and Applied Pharmacology,2019,374:20-31.
[60] SAMPSON T R,MAZMANIAN S K.Control of brain development,function,and behavior by the microbiome[J].Cell Host & Microbe,2015,17(5):565-576.
[61] PSICHAS A,SLEETH M L,MURPHY K G,et al.The short chain fatty acid propionate stimulates GLP-1 and PYY secretion
via free fatty acid receptor 2 in rodents[J].International Journal of Obesity,2015,39(3):424-429.
[62] NICHOLSON J K,HOLMES E,KINROSS J,et al.Host-gut microbiota metabolic interactions[J].Science,2012,336(6086):1262-1267.
[63] DESBONNET L,GARRETT L,CLARKE G,et al.The probiotic
Bifidobacteria infantis:an assessment of potential antidepressant properties in the rat[J].Journal of Psychiatric Research,2008,43(2):164-174.
[64] CHIMEREL C,EMERY E,SUMMERS D K,et al.Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells[J].Cell Reports,2014,9(4):1202-1208.
