Research Progress in Plant Natural Products as Bacterial Urease Inhibitors

  • ZHANG Zhenyu ,
  • ZHAO Shengguo ,
  • ZHENG Nan ,
  • WANG Jiaqi
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  • 1. Ministry of Agriculture, State Key Laboratory of Animal Nutrition, Beijing 100193, China;
    2. Key Laboratory of Quality and Safety Control for Milk and Dairy Products, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2020-08-09

  Online published: 2021-03-18

Supported by

 

Abstract

The overactive urease activity of ruminal microbiota leads to the excessive release rate of ammonia. This could reduce the efficiency of microbial protein synthesis, which in turn lower the utilization of microbial proteins by ruminants. Urease inhibitor bind to the active site of the urease and inhibit urease activity. Compared with physical coating methods and chemical synthesis methods, urease inhibitors have the advantage of simultaneously controlling the decomposition of exogenous and endogenous urea. Thus, it has great application potential. However, the current urease inhibitors have some problems such as strong biological toxicity and strong side effects, which limits the application of urease inhibitors. Plant extracts are one of the ideal sources of urease inhibitors with low biological toxicity and low side effects. In recent years, with the development of chemical purification technology, a series of plant extracts with urease inhibition bioactivity have been obtained. Through the structure-activity relationship analysis, these new compounds greatly enriched the urease inhibitory chemical skeleton structures. This article summarizes the plant extracts with urease inhibitory activity into categories and the structure-activity relationship and inhibition mode of different types of urease inhibitors, which aims to provide a reference for the development of novel urease inhibitors.

Cite this article

ZHANG Zhenyu , ZHAO Shengguo , ZHENG Nan , WANG Jiaqi . Research Progress in Plant Natural Products as Bacterial Urease Inhibitors[J]. Chinese Journal of Animal Nutrition, 2021 , 33(3) : 1306 -1317 . DOI: 10.3969/j.issn.1006-267x.2021.03.014

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