Biological Activity of Curcumin and Its Molecular Mechanism Regulating Intestinal Mucosal Barrier Function of Animals

  • RUAN Dong ,
  • WANG Yibing ,
  • JIANG Shouqun ,
  • ZHENG Chuntian
Expand
  • Guangdong Key Laboratory of Animal Breeding and Nutrition, Key Laboratory of Animal Nutrition and Feed Science of ministry of Agriculture in South China, State Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

Received date: 2020-08-28

  Online published: 2021-04-15

Supported by

 

Abstract

Curcumin is a natural plant polyphenol derived from the rhizomes of Curcuma longa that has antioxidant, anti-apoptosis, anti-inflammatory, immune modulation and metabolic regulation properties. Research shows that curcumin exerts physiological function mainly through pattern recognition receptors, nuclear receptors, apoptosis and autophagy signal pathways, and modulates cell proliferation and differentiation through energy metabolism. This review mainly expounded the mechanism of curcumin maintaining intestinal mucosal barrier function, in order to provide scientific theoretical basis for the development of new feed additives and animal breeding.

Cite this article

RUAN Dong , WANG Yibing , JIANG Shouqun , ZHENG Chuntian . Biological Activity of Curcumin and Its Molecular Mechanism Regulating Intestinal Mucosal Barrier Function of Animals[J]. Chinese Journal of Animal Nutrition, 2021 , 33(4) : 1801 -1810 . DOI: 10.3969/j.issn.1006-267x.2021.04.001

References

[1] HUSSAIN Z,EI THU H,AMJAD M W,et al.Exploring recent developments to improve antioxidant,anti-inflammatory and antimicrobial efficacy of curcumin:a review of new trends and future perspectives[J].Materials Science and Engineering:C,2017,77:1316-1326.
[2] KAUR H,HE B,ZHANG C H,et al.Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells:implications for the inhibition of protein synthesis and TNFα signaling[J].Journal of Nutritional Biochemistry,2018,57:276-286.
[3] KIM C Y.Inhibition of interleukin-1α-induced intestinal epithelial tight junction permeability by curcumin treatment in Caco-2 cells in Caco-2 cells[J].Journal of Life Science,2016,26(9):1082-1087.  
[4] GHOSH S S,HE H L,WANG J,et al.Curcumin-mediated regulation of intestinal barrier function:the mechanism underlying its beneficial effects[J].Tissue Barriers,2018,6(1):e1425085.
[5] LOPRESTI A L.The problem of curcumin and its bioavailability:could its gastrointestinal influence contribute to its overall health-enhancing effects?[J].Advances in Nutrition,2018,9(1):41-50.  
[6] SCAZZOCCHIO B,MINGHETTI L,D'ARCHIVIO M.Interaction between gut microbiota and curcumin:a new key of understanding for the health effects of curcumin[J].Nutrients,2020,12(9):2499.
[7] TSUDA T.Curcumin as a functional food-derived factor:degradation products,metabolites,bioactivity,and future perspectives[J].Food & Function,2018,9(2):705-714.  
[8] TIAN M P,SONG R X,WANG T,et al.Inducing sustained release and improving oral bioavailability of curcumin via chitosan derivatives-coated liposomes[J].International Journal of Biological Macromolecules,2018,120:702-710.
[9] KIMURA S,KIRIYAMA A,ARAKI K,et al.Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles[J].European Journal of Pharmaceutics and Biopharmaceutics,2018,122:1-5.
[10] BAN C,JO M,PARK Y H,et al.Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles[J].Food Chemistry,2020,302:125328.
[11] STOHS S J,CHEN O,RAY S D,et al.Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application:a review[J].Molecules,2020,25(6):1397.
[12] PRASAD S,TYAGI A K,AGGARWAL B B.Recent developments in delivery,bioavailability,absorption and metabolism of curcumin:the golden pigment from golden spice[J].Cancer Research and Treatment,2014,46(1):2-18.  
[13] ZHANG Z G,CHEN Y J,XIANG L H,et al.Effect of curcumin on the diversity of gut microbiota in ovariectomized rats[J].Nutrients,2017,9(10):1146.
[14] SHEN L,JI H F.Bidirectional interactions between dietary curcumin and gut microbiota[J].Critical Reviews in Food Science and Nutrition,2019,59(18):2896-2902.  
[15] PLUTA R,JANUSZEWSKI S,ULAMEK-KOZIOL M.Mutual two-way interactions of curcumin and gut microbiota[J].International Journal of Molecular Sciences,2020,21(3):1055.
[16] LUO D D,CHEN J F,LIU J J,et al.Tetrahydrocurcumin and octahydrocurcumin,the primary and final hydrogenated metabolites of curcumin,possess superior hepatic-protective effect against acetaminophen-induced liver injury:role of CYP2E1 and Keap1-Nrf2 pathway[J].Food and Chemical Toxicology,2019,123:349-362.
[17] YANG J Y,ZHONG X C,KIM S J,et al.Comparative effects of curcumin and tetrahydrocurcumin on dextran sulfate sodium-induced colitis and inflammatory signaling in mice[J].Journal of Cancer Prevention,2018,23(1):18-24.  
[18] ZHANG Z B,LUO D D,XIE J H,et al.Curcumin's metabolites,tetrahydrocurcumin and octahydrocurcumin,possess superior anti-inflammatory effects in vivo through suppression of TAK1-NF-κB pathway[J].Frontiers in Pharmacology,2018,9:1181.
[19] TEYMOURI M,BARATI N,PIRRO M,et al.Biological and pharmacological evaluation of dimethoxycurcumin:a metabolically stable curcumin analogue with a promising therapeutic potential[J].Journal of Cellular Physiology,2018,233(1):124-140.  
[20] LU M C,JI J A,JIANG Z Y,et al.The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target:an update[J].Medicinal Research Reviews,2016,36(5):924-963.  
[21] BAI X P,CHEN Y B,HOU X Y,et al.Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters[J].Drug Metabolism Reviews,2016,48(4):541-567.  
[22] WEN Z Y,LIU W H,LI X,et al.A protective role of the Nrf2-Keap1 pathway in maintaining intestinal barrier function[J].Oxidative Medicine and Cellular Longevity,2019,2019:1759149.
[23] WANG N,WANG G,HAO J X,et al.Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal epithelial cells[J].Digestive Diseases and Sciences,2012,57(7):1792-1801.  
[24] YAN E F,ZHANG J Q,HAN H L,et al.Curcumin alleviates IUGR jejunum damage by increasing antioxidant capacity through Nrf2/Keap1 pathway in growing pigs[J].Animals,2020,10(1):41.
[25] RUAN D,ZHU Y W,FOUAD A M,et al.Dietary curcumin enhances intestinal antioxidant capacity in ducklings via altering gene expression of antioxidant and key detoxification enzymes[J].Poultry Science,2019,98(9):3705-3714.  
[26] BALAJI S,CHEMPAKAM B.Toxicity prediction of compounds from turmeric (Curcuma longa L)[J].Food and Chemical Toxicology,2010,48(10):2951-2959.  
[27] QIU P Y,MAN S L,LI J,et al.Overdose intake of curcumin initiates the unbalanced state of bodies[J].Journal of Agricultural and Food Chemsitry,2016,64(13):2765-2771.  
[28] SINGH R,CHANDRASHEKHARAPPA S,BODDULURI S R,et al.Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway[J].Nature Communications,2019,10:89.
[29] SHEN L,LIU L,JI H F.Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications[J].Food Nutrition Research,2017,61:1361780.
[30] PETERSON C T,VAUGHN A R,SHARMA V,et al.Effects of turmeric and curcumin dietary supplementation on human gut microbiota:a double-blind,reandomized,placebo-controlled pilot study[J].Journal of Evidence-Based Integrative Medicine,2018,23:2515690X18790725.
[31] LOGANES C,LEGA S,BRAMUZZO M,et al.Curcumin anti-apoptotic action in a model of intestinal epithelial inflammatory damage[J].Nutrients,2017,9(6):578.
[32] FUKUDA K,UEHARA Y,NAKATA E,et al.A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa[J].International Journal of Radiation Biology,2016,92(7):388-394.  
[33] KIM J Y,LEE Y M,KIM D W,et al.Nanosphere loaded with curcumin inhibits the gastrointestinal cell death signaling pathway induced by the foodborne pathogen Vibrio vulnificus[J].Cells,2020,9(3):631.
[34] RUAN D,WANG W C,LIN C X,et al.Effects of curcumin on performance,antioxidation,intestinal barrier and mitochondrial function in ducks fed corn contaminated with ochratoxin A[J].Animal,2019,13(1):42-52.  
[35] RAVANAN P,SRIKUMAR I F,TALWAR P.Autophagy:the spotlight for cellular stress responses[J].Life Sciences,2017,188:53-57.
[36] COSIN-ROGER J,SIMMEN S,MELHEM H,et al.Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation[J].Nature Communications,2017,8:98.
[37] WONG M,GANAPATHY A S,SUCHANEC E,et al.Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin[J].American Journal of Physiology-Cell Physiology,2019,316(5):753-765.  
[38] SHAKERI A,CICERO A F G,PANAHI Y,et al.Curcumin:a naturally occurring autophagy modulator[J].Journal of Cellular Physiology,2019,234(5):5643-5654.  
[39] ZHANG J B,WANG J G,XU J,et al.Curcumin targets the TFEB-lysosome pathway for induction of autophagy[J].Oncotarget,2016,7(46):75659-75671.  
[40] CAO S T,WANG C C,YAN J T,et al.Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway[J].Free Radical Biology and Medicine,2020,147:8-22.
[41] ZHANG W J,HUANG Q B,ZENG Z H,et al.Sirt1 inhibits oxidative stress in vascular endothelial cells[J].Oxidative Medicine and Cellular Longgevity,2017,2017:7543973.
[42] REN M T,GU M L,ZHOU X X,et al.Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis[J].World Journal Gastroenterol,2019,25(38):5800-5813.  
[43] OU X,LEE M R,HUANG X X,et al.SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress[J].Stem Cells,2014,32(5):1183-1194.  
[44] IGARASHI M,GUARENTE L.mTORC1 and SIRT1 cooperate to foster expansion of gut adult stem cells during calorie restriction[J].Cell,2016,166(2):436-450.  
[45] LIANG D Y,ZHUO Y S,GUO Z H,et al.SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells[J].Biochimie,2020,170:10-20.
[46] ZHANG L Z,XUE H,ZHAO G,et al.Curcumin and resveratrol suppress dextran sulfate sodium-induced colitis in mice[J].Molecular Medicine Reports,2019,19(4):3053-3060.
[47] HAN J,PAN X Y,XU Y,et al.Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage[J].Autophagy,2012,8(5):812-825.  
[48] WELLMAN A S,METUKURI M R,KAZGAN N,et al.Intestinal epithelial sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota[J].Gastroenterology,2017,153(3):772-786.  
[49] MARTIN P K,MARCHIANDO A,XU R L,et al.Autophagy proteins suppress protective type Ⅰ interferon signalling in response to the murine gut microbiota[J].Nature Microbiology,2018,3(10):1131-1141.  
[50] LARABI A,BARNICH N,NGUYEN H T T.New insights into the interplay between autophagy,gut microbiota and inflammatory responses in IBD[J].Autophagy,2020,16(1):38-51.  
[51] LU Y,LI X R,LIU S S,et al.Toll-like receptors and inflammatory bowel disease[J].Frontiers in Immunology,2018,9:72.
[52] VIJAY K.Toll-like receptors in immunity and inflammatory diseases:past,present,and future[J].International Immunopharmacology,2018,59:391-412.
[53] FITZGERALD K A,KAGAN J C.Toll-like receptors and the control of immunity[J].Cell,2020,180(6):1044-1066.  
[54] BOOZARI M,BUTLER A E,SAHEBKAR A.Impact of curcumin on Toll-like receptors[J].Journal of Cellular Physiology,2019,234(8):12471-12482.  
[55] CHEN J J,DAI L,ZHAO L X,et al.Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis[J].Scientific Reports,2015,5:10278.
[56] WANG J,GHOSH S S,GHOSH S.Curcumin improves intestinal barrier function:modulation of intracellular signaling,and organization of tight junctions[J].American Journal of Physiology:Cell Physiology,2017,312(4):C438-C445.
[57] GAN Z D,WEI W Y,LI Y,et al.Curcumin and resveratrol regulate intestinal bacteria and alleviate intestinal inflammation in weaned piglets[J].Molecules,2019,24(7):1220.
[58] LIU T,ZHANG L Y,JOO D,et al.NF-κB signaling in inflammation[J].Signal Transduction and Targeted Therapy,2017,2:17023.
[59] TIAN S Y,GUO R X,WEI S C,et al.Curcumin protects against the intestinal ischemia-reperfusion injury:involvement of the tight junction protein ZO-1 and TNF-α related mechanism[J].Korean Journal of Physiology and Pharmacology,2016,20(2):147-152.  
[60] ECKERT J,SCOTT B,LAWRENCE S M,et al.FLLL32,a curcumin analog,ameliorates intestinal injury in necrotizing enterocolitis[J].Journal of Inflammation Research,2017,10:75-81.
[61] BURGE K,GUNASEKARAN A,ECKERT J,et al.Curcumin and intestinal inflammatory diseases:molecular mechanisms of protection[J].International Journal of Molecular Sciences,2019,20(8):1912.
[62] MA F Y,LIU F,DING L,et al.Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice[J].Pharmaceutical Biology,2017,55(1):1263-1273.  
[63] ABDOLLAHI E,MOMTAZI A A,JOHNSTON T P,et al.Therapeutic effects of curcumin in inflammatory and immune-mediated diseases:a nature-made jack-of-all-trades?[J].Journal of Cellular Physiology,2018,233(2):830-848.  
[64] OMENETTI S,PIZARRO T T.The Treg/Th17 axis:a dynamic balance regulated by the gut microbiome[J].Frontiers in Immunology,2015,6:639.
[65] ZHAO H M,XU R,HUANG X Y,et al.Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice[J].World Journal of Gastroenterology,2016,22(23):5374-5383.  
[66] ZHAO G M,LIU Y,YI X Y,et al.Curcumin inhibiting Th17 cell differentiation by regulating the metabotropic glutamate receptor-4 expression on dendritic cells[J].International Immunopharmacology,2017,46:80-86.
[67] OHNO M,NISHIDA A,SUGITANI Y,et al.Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells[J].PLoS One,2017,12(10):e0185999.
Outlines

/