[1] LAVOIE S,CONWAY K L,LASSEN K G,et al.The Crohn's disease polymorphism,ATG16L1 T300A,alters the gut microbiota and enhances the local Th1/Th17 response[J].eLife,2019,8:e39982.
[2] XIE A Y,ROBLES R J,MUKHERJEE S,et al.HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease[J].Journal of Autoimmunity,2018,94:122-133.
[3] CUI H T,CAI Y Z,WANG L,et al.Berberine regulates Treg/Th17 balance to treat ulcerative colitis through modulating the gut microbiota in the colon[J].Frontiers in Pharmacology,2018,9:571.
[4] KAPLAN G G.The global burden of IBD:from 2015 to 2025[J].Nature Reviews Gastroenterology & Hepatology,2015,12(12):720-727.
[5] KLOTZ C,BARRET M,DHOOGE M,et al.Management of diagnosis and treatment in ulcerative colitis[J].La Presse Médicale,2015,44(2):144-149.
[6] CLARKE K,CHINTANABOINA J.Allergic and immunologic perspectives of inflammatory bowel disease[J].Clinical Reviews in Allergy & Immunology,2019,57(2):179-193.
[7] ROSEN M J,DHAWAN A,SAEED S A.Inflammatory bowel disease in children and adolescents[J].JAMA Pediatrics,2015,169(11):1053-1060.
[8] 邓蓓蓓.黄芪多糖对重症急性胰腺炎大鼠肠黏膜屏障损伤的保护作用[D].硕士学位论文.长春:吉林大学,2017. DENG B B.Protective effect of astragalus polysaccharide on intestinal barrier dysfunction in rats with severe acute pancreatitis[D].Master's Thesis.Changchun:Jilin University,2017.(in Chinese)
[9] LATELLA G,PAPI C.Crucial steps in the natural history of inflammatory bowel disease[J].World Journal of Gastroenterology,2012,18(29):3790-3799.
[10] DANESE S,GRISHAM M,HODGE J,et al.JAK inhibition using tofacitinib for inflammatory bowel disease treatment:a hub for multiple inflammatory cytokines[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2016,310(3):G155-G162.
[11] VUITTON L,KOCH,S,PEYRIN-BIROULET L.Janus kinase inhibition with tofacitinib:changing the face of inflammatory bowel disease treatment[J].Current Drug Targets,2013,14(12):1385-1391..
[12] LI N,SUN W J,ZHOU X,et al.Dihydroartemisinin protects against dextran sulfate sodium-induced colitis in mice through inhibiting the PI3K/AKT and NF-κB signaling pathways[J].Biomed Research International,2019,2019:1415809.
[13] LEE G R.The balance of Th17 versus Treg cells in autoimmunity[J].International Journal of Molecular Sciences,2018,19(3):730.
[14] HAN L,YANG J,WANG X W,et al.Th17 cells in autoimmune diseases[J].Frontiers of Medicine,2015,9(1):10-19.
[15] HAASE S,WILCK N,KLEINEWIETFELD M,et al.Sodium chloride triggers Th17 mediated autoimmunity[J].Journal of Neuroimmunology,2019,329:9-13.
[16] YANG L,FANOK M H,MEDIERO-MUNOZ A,et al.Augmented Th17 differentiation leads to cutaneous and synovio-entheseal inflammation in a novel model of psoriatic arthritis[J].Arthritis & Rheumatology,2018,70(6):855-867.
[17] OGINO H,NAKAMURA K,IHARA E,et al.CD4
+CD25
+ regulatory T cells suppress Th17-responses in an experimental colitis model[J].Digestive Diseases and Sciences,2011,56(2):376-386.
[18] JIN S W,CHEN H J,LI Y S,et al.Maresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21[J].Annals of the Rheumatic Diseases,2018,77(11):1644-1652.
[19] FASCHING P,STRADNER M,GRANINGER W,et al.Therapeutic potential of targeting the TH17/Treg axis in autoimmune disorders[J].Molecules,2017,22(1):134.
[20] 陈志新.猪腹泻的病因分析与防治原则[J].畜牧与饲料科学,2010,31(8):168-169. CHEN Z X.Etiological analysis and principles of prevention and treatment of swine diarrhea[J].Animal Husbandry and Feed Science,2010,31(8):168-169.(in Chinese)
[21] 李浩然.中药白痢散治疗仔猪白痢的有效性和安全性研究[D].硕士学位论文.长春:吉林大学,2018. LI H R.Efficacy and safety of BAILISAN on piglet white scour[D].Master's Thesis.Changchun:Jilin University,2018.(in Chinese)
[22] 张赛奇.葛芪复方对仔猪大肠杆菌性腹泻作用效果研究[D].硕士学位论文.北京:中国农业科学院,2015. ZHANG S Q.The study of the effect of "
Geqi" Chinese herb compound on the piglets diarrhea induced by the E.coli[D].Master's Thesis.Beijing:Chinese Academy of Agricultural Sciences,2015.(in Chinese)
[23] 申正杰.某猪场保育猪腹泻发病调查及血管紧张素转化酶2(ACE2)抗炎作用的初步探讨[D].硕士学位论文.南京:南京农业大学,2018. SHEN Z J.Investigation on diarrhea incidence and anti-inflammatory effect of angiotensin converting enzyme 2(ACE2) in nursery swines on a porcine shed[D].Master's Degree.Thesis.Nanjing:Nanjing Agricultural University,2018.(in Chinese)
[24] 孟相秋.黑龙江省犊牛腹泻粪便中大肠杆菌的毒力基因和耐药性调查[D].硕士学位论文.哈尔滨:东北农业大学,2014. MENG X Q.The investigation of virulence genes and antibiotic resistance of
E.coli strain isolated from feces of calves with diarrhea in Heilongjiang province[D].Master's Thesis.Harbin:Northeast Agricultural University,2014.(in Chinese)
[25] 王晓云.肠神经胶质细胞在坏死性肠炎鸡肠道中的分布及部分分泌因子的研究[D].硕士学位论文.石河子:石河子大学,2018. WANG X Y.Study on distribution of enteric glial cells and its endocrine production in the intestinal tract o necrotic enteritis of chickens[D].Master's Degree.Thesis.Shihezi:Shihezi University,2018.(in Chinese)
[26] 阚刘刚,刘艳,吴媛媛,等.鸡坏死性肠炎模型构建和发病机理研究进展[J].中国家禽,2019,41(13):41-46. KAN L G,LIU Y,WU Y Y,et al.Advances in model development and pathogenesis mechanisms of avian necrotic enteritis[J].China Poultry,2019,41(13):41-46.(in Chinese)
[27] KALDHUSDAL M,BENESTAD S L,LØVLAND A.Epidemiologic aspects of necrotic enteritis in broiler chickens-disease occurrence and production performance[J].Avian Pathology,2016,45(3):271-274.
[28] CHEN T,GUO J F,CAI Z H,et al.Th9 cell differentiation and its dual effects in tumor development[J].Frontiers in Immunology,2020,11:1026.
[29] RUAN Q G,KAMESWARAN V,ZHANG Y,et al.The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis[J].Journal of Experimental Medicine,2011,208(11):2321-2333.
[30] WAN C K,ANDRASKI A B,SPOLSKI R,et al.Opposing roles of STAT1 and STAT3 in IL-21 function in CD4
+ T cells[J].Proceedings of the National Academy of Sciences of the United States of America,2015,112(30):9394-9399.
[31] MILOVANOVIC J,ARSENIJEVIC A,STOJANOVIC B,et al.Interleukin-17 in chronic inflammatory neurological diseases[J].Frontiers in Immunology,2020,11:947.
[32] KORN T,BETTELLI E,OUKKA M,et al.IL-17 and Th17 cells[J].Annual Review of Immunology,2009,27:485-517.
[33] FASCHING P,STRADNER M,GRANINGER W,et al.Therapeutic potential of targeting the Th17/Treg axis in autoimmune disorders[J].Molecules,2017,22:134.
[34] DENG G P,SONG X M,FUJIMOTO S,et al.Foxp3 post-translational modifications and treg suppressive activity[J].Frontiers in Immunology,2019,10:2486.
[35] CHEROUTRE H.Starting at the beginning:new perspectives on the biology of mucosal T cells[J].Annual Review of Immunology,2004,22:217-246.
[36] SCHIAVON V,DUCHEZ S,BRANCHTEIN M,et al.Microenvironment tailors nTreg structure and function[J].Proceedings of the National Academy of Sciences of the United States of America,2019,116(13):6298-6307.
[37] VAN WIJK F,CHEROUTRE H.Mucosal T cells in gut homeostasis and inflammation[J].Expert Review of Clinical Immunology,2010,6(4):559-566.
[38] WHITESIDE T L.FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity[J].Expert Opinion on Therapeutic Targets,2018,22(4):353-363.
[39] MOSHAPA F T,RICHES-SUMAN K,PALMER T M.Therapeutic targeting of the proinflammatory IL-6-JAK/STAT signalling pathways responsible for vascular restenosis in type 2 diabetes mellitus[J].Cardiology Research & Practice,2019,2019:9846312.
[40] SCHAPER F,ROSE-JOHN S.Interleukin-6:biology,signaling and strategies of blockade[J].Cytokine & Growth Factor Reviews,2015,26(5):475-487.
[41] ROSE-JOHN S.IL-6 trans-signaling via the soluble IL-6 receptor:importance for the pro-inflammatory activities of IL-6[J].International Journal of Biological Sciences,2012,8(9):1237-1247.
[42] ARNOLD P,LÜCKSTÄDT W,LI W J,et al.Joint reconstituted signaling of the IL-6 receptor via extracellular vesicles[J].Cells,2020,9(5):1037.
[43] ZEGEYE M M,LINDKVIST M,FÄLKER K,et al.Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells[J].Cell Communication and Signaling,2018,16(1):55.
[44] BANERJEE S,BIEHL A,GADINA M,et al.JAK-STAT signaling as a target for inflammatory and autoimmune diseases:current and future prospects[J].Drugs,2017,77(5):521-546.
[45] VASBINDER M M,ALIMZHANOV M,AUGUSTIN M,et al.Identification of azabenzimidazoles as potent JAK1 selective inhibitors[J].Bioorganic & Medicinal Chemistry Letters,2016,26(1):60-67.
[46] WU P,NIELSEN T E,CLAUSEN M H.FDA-approved small-molecule kinase inhibitors[J].Trends in Pharmacological Sciences,2015,36(7):422-439.
[47] MIN X S,UNGUREANU D,MAXWELL S,et al.Structural and functional characterization of the JH2 pseudokinase domain of JAK family tyrosine kinase 2(TYK2)[J].Journal of Biological Chemistry,2015,290(45):27261-27270.
[48] GHORESCHI K,LAURENCE A,O'SHEA J J.Janus kinases in immune cell signaling[J].Immunological Reviews,2009,228(1):273-287.
[49] KICINSKA A,LELUK J,JARMUSZKIEWICZ W.
Acanthamoeba castellanii STAT protein[J].PLoS One,2014,9(10):e111345.
[50] XU A T,LI Y,ZHAO D,et al.High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission[J].Inflammatory Bowel Diseases,2015,21(2):241-250.
[51] SCHWARTZ D M,BONELLI M,GADINA M,et al.Type Ⅰ/Ⅱ cytokines,JAKs,and new strategies for treating autoimmune diseases[J].Nature Reviews Rheumatology,2016,12(1):25-36.
[52] CHOY E H.Clinical significance of Janus kinase inhibitor selectivity[J].Rheumatology,2019,58(6):953-962.
[53] VILLARINO A V,KANNO Y,O'SHEA J J.Mechanisms and consequences of Jak-STAT signaling in the immune system[J].Nature Immunology,2017,18(4):374-384.
[54] ROSKOSKI R,Jr.Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases[J].Pharmacological Research,2016,111:784-803.
[55] YOSHIMURA T,TAKEDA A,HAMANO S,et al.Two-sided roles of IL-27:induction of Th1 differentiation on naive CD4
+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4
+ T cells partially through STAT3-dependent mechanism[J].The Journal of Immunology,2006,177(8):5377-5385.
[56] 孙志高.补脾和胃方减轻5-Fu化疗大鼠肠道微生态损害及对Th17/Treg信号通路的调节机制[D].博士学位论文.北京:中国人民解放军医学院,2019. SUN Z G.BuPiHeWei decoction ameliorate 5-fluorouracil-induced intestinal microecological disorder in rats by regulating the Th17/Treg signaling pathway[D].Ph.D.Thesis.Beijing:Chinese People's Liberation Army Medical College,2019.(in Chinese)
[57] ARORA S,AHMAD S,IRSHAD R,et al.TLRs in pulmonary diseases[J].Life Sciences,2019,233:116671.
[58] GEREMIA A,BIANCHERI P,ALLAN P,et al.Innate and adaptive immunity in inflammatory bowel disease[J].Autoimmunity Reviews,2014,13(1):3-10.
[59] HAYDEN M S,GHOSH S.NF-κB,the first quarter-century:remarkable progress and outstanding questions[J].Genes & Development,2012,26(3):203-234.
[60] 陈曦.Toll样受体4与β防御素2在结肠炎上皮表达及调控的研究[D].博士学位论文.成都:四川大学,2005. CHEN X.Expression of TLR4 and HBD2 in intestina epithelium of Ulcerative Colitis[D].Ph.D.Thesis.Chengdu:Sichuan University,2005.(in Chinese)
[61] 李斌.乌梅丸及其拆方对溃疡性结肠炎大鼠TLR9/MyD88/NF-κBp65及IL-6/JAK/STAT3信号通路的影响[D].博士学位论文.沈阳:辽宁中医药大学,2016. LI B.Effects of Wumei Pill and its decomposed formulas on TLR9/MyD88/NF-κBp65 and IL-6/JAK/STAT3 signaling pathways in rats with ulcerative colitis[D].Ph.D.Thesis.Shenyang:Liaoning University of Traditional Chinese Medicine,2016.(in Chinese)
[62] FERNANDEZ-GONZALO R,DE PAZ J A,RODRIGUEZ-MIGUELEZ P,et al.TLR4-mediated blunting of inflammatory responses to eccentric exercise in young women[J].Mediators of Inflammation,2014,2014:479395.
[63] ZHANG Q,LENARDO M J,BALTIMORE D.30 Years of NF-κB:a blossoming of relevance to human pathobiology[J].Cell,2017,168(1/2):37-57.
[64] BARNES S E,WANG Y,CHEN L Q,et al.T cell-NF-κB activation is required for tumor control
in vivo[J].Journal for Immunotherapy of Cancer,2015,3(1):1.
[65] OH H,GRINBERG-BLEYER Y,LIAO W,et al.An NF-κB transcription-factor-dependent lineage-specific transcriptional program promotes regulatory T cell identity and function[J].Immunity,2017,47(3):450-465.e5.
[66] MUSSBACHER M,SALZMANN M,BROSTJAN C,et al.Cell type-specific roles of NF-κB linking inflammation and thrombosis[J].Frontiers in Immunology,2019,10:85.
[67] VISEKRUNA A,HUBER M,HELLHUND A,et al.c-Rel is crucial for the induction of Foxp3
+ regulatory CD4
+ T cells but not TH17 cells[J].European Journal of Immunology,2010,40(3):671-676.
[68] CHEN G B,HARDY K,PAGLER E,et al.The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis[J].The Journal of Immunology,2011,187(9):4483-4491.
[69] GRINBERG-BLEYER Y,OH H,DESRICHARD A,et al.NF-κB c-Rel is crucial for the regulatory T cell immune checkpoint in cancer[J].Cell,2017,170(6):1096-1108.e13.
[70] RUAN Q G,CHEN Y H.Nuclear factor-κB in immunity and inflammation:the Treg and Th17 connection[M]//LAMBRIS J,HAJISHENGALLIS G.Current topics in innate immunity Ⅱ.New York,NY:Springer,2012,946:207-221.
[71] HILLMANN P,FABBRO D.PI3K/mTOR pathway inhibition:opportunities in oncology and rare genetic diseases[J].International Journal of Molecular Sciences,2019,20(22):5792.
[72] DIBBLE C C,CANTLEY L C.Regulation of mTORC1 by PI3K signaling[J].Trends in Cell Biology,2015,25(9):545-555.
[73] SINGH S S,YAP W N,ARFUSO F,et al.Targeting the PI3K/Akt signaling pathway in gastric carcinoma:A reality for personalized medicine?[J].World Journal of Gastroenterology,2015,21(43):12261-12273.
[74] SWITON K,KOTULSKA K,JANUSZ-KAMINSKA A,et al.Molecular neurobiology of mTOR[J].Neuroscience,2017,341:112-153.
[75] YANG H S,XIONG X,LI T J,et al.Ethanolamine enhances the proliferation of intestinal epithelial cells via the mTOR signaling pathway and mitochondrial function[J].In Vitro Cellular & Developmental Biology-Animal,2016,52(5):562-567.
[76] QIN Q,XU X,WANG X Y,et al.Glutamate alleviates intestinal injury,maintains mTOR and suppresses TLR4 and NOD signaling pathways in weanling pigs challenged with lipopolysaccharide[J].Scientific Reports,2018,8:15124.
[77] KEPPLER-NOREUIL K M,PARKER V E R,DARLING T N,et al.Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies[J].American Journal of Medical Genetics Part C:Seminars in Medical Genetics,2016,172(4):402-421.
[78] 孟宪邑.娃儿藤碱类化合物W-8对Treg细胞分化调控作用的研究[D].博士学位论文.天津:南开大学,2012. MENG X Y.Study on the regulatory of a novel tylophorine analog W-8 on Treg differentiation[D].Ph.D.Thesis.Tianjin:Nankai University,2012.(in Chinese)
[79] BERTACCHINI J,HEIDARI N,MEDIANI L,et al.Targeting PI3K/AKT/mTOR network for treatment of leukemia[J].Cellular and Molecular Life Sciences,2015,72(12):2337-2347.
[80] WANG P,ZHANG Q,TAN L,et al.The regulatory effects of mTOR complexes in the differentiation and function of CD4
+ T cell subsets[J].Journal of Immunology Research,2020,2020:3406032.
[81] WANG S Y,HUANG Y,ZHOU C L,et al.The role of autophagy and related microRNAs in inflammatory bowel disease[J].Gastroenterology Research and Practice,2018,2018:7565076.
[82] ZENG H,CHI H B.Metabolic control of regulatory T cell development and function[J].Trends in Immunology,2015,36(1):3-12.
[83] ZHANG H C,DAI Y,LIU Y,et al.
Helicobacter pylori colonization protects against chronic experimental colitis by regulating Th17/Treg balance[J].Inflammatory Bowel Diseases,2018,24(7):1481-1492.
[84] 付正伟,王丽霞,葛海燕.芦荟多糖调控Th17/Treg细胞平衡缓解肠炎的实验研究[J].中华普通外科学文献(电子版),2019,13(6):435-440. FU Z W,WANG L X,GE H Y.Experimental study of the aloe polysaccharides relieving enteritis by regulating Th17/Treg cell balance[J].Chinese Archives of General Surgery(Electronic Edition),2019,13:435-440. (in Chinese)
[85] ZHU J F,XU Y,ZHAO J,et al.IL-33 protects mice against DSS-induced chronic colitis by increasing both regulatory B cell and regulatory T cell responses as well as decreasing Th17 Cell response[J].Journal of Immunology Research,2018,2018:1827901.
[86] YOUNG D,IBUKI M,NAKAMORI T,et al.Soy-derived Di- and tripeptides alleviate colon and ileum inflammation in pigs with dextran sodium sulfate-induced colitis[J].The Journal of Nutrition,2012,142(2):363-368.
[87] 陈光华,陈教华,张磊昌.姜黄素通过IL-6/STAT3信号通路调控Th17/Treg平衡治疗溃疡性结肠炎[J].中国病理生理杂志,2019,35(11):2092-2097,2102. CHEN G H,CHEN J H,ZHANG L C.Curcumin regulates Th17/Treg balance in treatment of ulcerative colitis by IL-6/STAT3 signaling pathway[J].Chinese Journal of Pathophysiology,2019,35:2092-2097,2102.(in Chinese)
[88] 王斌.
L-色氨酸缓解动物肠道炎症的作用机制研究[D].博士学位论文.北京:中国农业大学,2018. WANG B.Study of the mechanism for the regulatory role of
L-tryptophan inallebiating intestinal inflammation in animal[D].Ph.D.Thesis.Beijing:China Agricultural University,2018.(in Chinese)
[89] KIM C J,KOVACS-NOLAN J A,YANG C B,et al.
L-tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis[J].The Journal of Nutritional Biochemistry,2010,21(6):468-475.
[90] 易宏波.抗菌肽CWA对断奶仔猪肠道炎症和肠道屏障功能的作用及其机制[D].博士学位论文.杭州:浙江大学,2016. YI H B.Effects an mechanisms of antimicrbial peptide CWA on intestinal inflammation and intestinal barrier functions in weaned piglets[D].Ph.D.Thesis.Hangzhou:Zhejiang University,2017.(in Chinese)
[91] 巩栋梁.TLR4/NF-κB信号通路调控猪热应激性炎性肠病的分子机制[D].硕士学位论文.湛江:广东海洋大学,2018. GONG D L.The molecular mechanism of TLR4/NF-κB signaling pathway contributing to heat stress-induced porcine inflammatory bowel disease[D].Master's Degree.Thesis.Zhanjiang:Guangdong Ocean University,2018.(in Chinese)
[92] ZHAO J,SUN Y,SHI P L,et al.Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy[J].International Immunopharmacology,2015,26(1):221-228.
[93] XU X,WANG X Y,WU H T,et al.Glycine relieves intestinal injury by maintaining mtor signaling and suppressing AMPK,TLR4,and NOD signaling in weaned piglets after lipopolysaccharide challenge[J].International Journal of Molecular Sciences,2018,19(7):1980.
[94] YI D,HOU Y Q,XIAO H,et al.N-acetylcysteine improves intestinal function in lipopolysaccharides-challenged piglets through multiple signaling pathways[J].Amino Acids,2017,49(12):1915-1929.
[95] SHAO Y X,WOLF P G,GUO S S,et al.Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells[J].The Journal of Nutritional Biochemistry,2017,43:18-26.
