Effects of Calcium and Phosphorus on Growth Performance, Blood Physiological-Biochemical Indices and Mineral Element Metabolism of Immunosuppressed Piglets

  • LI Jing ,
  • NI Hengjia ,
  • HUANG Yonggang ,
  • LI Meng ,
  • TAN Bi'e
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  • 1. Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

Received date: 2020-09-18

  Online published: 2021-04-15

Supported by

 

Abstract

The aim of this study was to investigate the effects of calcium and phosphorus on growth performance, blood physiological-biochemical indices and mineral element metabolism of immunosuppressed piglets. Eighteen Duroc×Landrace×Yorkshire weaned piglets at 22 days of age were selected and randomly divided into three groups, each group consisting of six replicates with one piglet per pen. The control group and model group were fed a basal diet, while the experimental group was fed a diet containing a higher level of calcium and phosphorus[1.5 times NRC (2012) standard]. On the 23rd day, piglets in the model group and the experimental group were injected intraperitoneally with 18 mg/kg BW irinotecan (CPT) for 4 days, which was used to establish the immunosuppressed piglet model. While piglets in the control group was injected with the same amount of normal saline. The experiment lasted for 28 days. The results showed as follows:1) compared with the control group, the intraperitoneal injection of CPT significantly reduced the average daily weight gain of piglets (P<0.05), and significantly increased the feed to gain ratio and the diarrhea index (P<0.05); dietary calcium and phosphorus significantly relieved the diarrhea in immunosuppressed piglets (P<0.05), which was helpful in the improvement of the growth performance. 2) The immune cells such as leukocytes, neutrophils and monocytes in the blood of immunosuppressed piglets were significantly reduced compared with the control group (P<0.05), dietary calcium and phosphorus relieve the impact on the monocytes. 3) Compared with the control group, the copper content in serum increased significantly (P<0.05), and the copper content in colonic digesta decreased significantly in immunosuppressed piglets (P<0.05). It suggested that the copper utilization improvement might facilitate the repair of immune function, which was a positive feedback on the regulation of immunosuppression. Dietary calcium and phosphorus had no significant effect on the metabolism of metal trace elements in immunosuppressed piglets (P>0.05). In conclusion, dietary 1.5 times NRC (2012) calcium and phosphorus can effectively relieve diarrhea symptoms, improve the growth performance, and promote the recovery of immune function in immunosuppressed piglets caused by CPT.

Cite this article

LI Jing , NI Hengjia , HUANG Yonggang , LI Meng , TAN Bi'e . Effects of Calcium and Phosphorus on Growth Performance, Blood Physiological-Biochemical Indices and Mineral Element Metabolism of Immunosuppressed Piglets[J]. Chinese Journal of Animal Nutrition, 2021 , 33(4) : 1954 -1963 . DOI: 10.3969/j.issn.1006-267x.2021.04.016

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