Effects of Dietary Different Addition Levels of Zinc on Fat Deposition and Fat Metabolism Related Genes Expression of Growing Rex Rabbits

  • LI Shu ,
  • LIU Yongxu ,
  • ZHANG Yujuan ,
  • ZHAO Hong ,
  • YANG Gouyu ,
  • LIU Gongyan ,
  • LIU Lei ,
  • LI Fuchang
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  • 1. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China;
    2. Qingdao Kangda Food Co., Ltd., Qingdao 266555, China;
    3. Shandong Rehabilitation Hospital, Ji'nan 250109, China;
    4. Animal Husbandry and Veterinary Institute, Shandong Academy of Agricultural Sciences, Ji'nan 250100, China

Received date: 2020-09-03

  Online published: 2021-04-15

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Abstract

The aim of this study was to investigate the effects of dietary with different addition levels of zinc on fat deposition and fat metabolism related genes expression of growing Rex rabbits. One hundred and sixty 3-month-old Rex rabbits with similar body weight were selected and randomly divided into 4 groups (40 replicates per group and 1 rabbit per replicate). Rabbits in the 4 groups were fed diets supplemented with 0 (control group), 40, 80 and 120 mg/kg zinc (in the form of zinc sulfate) based on a basal diet, respectively. The preliminary feeding period sustained for 7 days, and the experimental feeding period sustained for 49 days. The results showed as follows:1) with the increase of zinc addition level in diet, there was no significant change in the scapular fat deposition of growing Rex rabbits (P>0.05), but the perirenal fat deposition showed a decreasing trend (P=0.095 3). 2) Dietary with different addition levels of zinc had no significant effects on the mRNA expression levels of acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), peroxisome proliferator-activated receptor γ (PPARγ) and fatty acid transporter (FATP) in scapular fat and perirenal fat and peroxisome proliferator-activated receptor α (PPARα) and fatty acid binding protein (FABP) in perirenal fat (P>0.05). Compared with the control group, added with 120 mg/kg zinc in the diet significantly increased the mRNA expression levels of carnitine palmitoyl transferase 1 (CPT1) and hormone sensitive lipase (HSL) in scapular fat and perirenal fat and FABP in scapular fat (P<0.05), and significantly decreased the mRNA expression levels of LPL in scapular fat and perirenal fat (P<0.05). In conclusion, dietary added with 120 mg/kg zinc (in the form of zinc sulfate) can enhance the expression of related genes in the process of lipid decomposition, increase the process of lipolysis and fatty acids oxidation, so that the fat deposition has a tendence to decrease.

Cite this article

LI Shu , LIU Yongxu , ZHANG Yujuan , ZHAO Hong , YANG Gouyu , LIU Gongyan , LIU Lei , LI Fuchang . Effects of Dietary Different Addition Levels of Zinc on Fat Deposition and Fat Metabolism Related Genes Expression of Growing Rex Rabbits[J]. Chinese Journal of Animal Nutrition, 2021 , 33(4) : 2245 -2252 . DOI: 10.3969/j.issn.1006-267x.2021.04.043

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