Effects of Dietary Lycium barbarum Polysaccharide on Growth Performance, Antioxidant Capacity, Intestinal Mucosal Immune Function and Intestinal Morphology of Weaned Rats

  • YIN Yexin ,
  • WANG Fang ,
  • YU Dongming ,
  • WANG Xin ,
  • FU Chenxing ,
  • CHEN Jiashun
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  • 1. Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

Received date: 2020-09-17

  Online published: 2021-04-15

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Abstract

The objective of the present study was to investigate the effects of dietary Lycium barbarum polysaccharide (LBP) on growth performance, antioxidant capacity, intestinal mucosal immune function and intestinal morphology of weaned rats. Twenty healthy weaned male SD rats, based on the similar body weight, were randomly assigned to two groups with ten replicates of one rat each. The rats in control groups were fed a basal diet, and those in LBP group were fed an experiment diet which supplemented with 4 g/kg LBP based on the basal diet. The experiment lasted for 28 d. The results showed as follows:1) compared with the control group, the average daily gain (ADG) in the LBP group was increased by 16.3% (P<0.05). 2) Compared with the control group, the serum total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) activity in the LBP group were increased by 52.8% (P<0.05) and 67.5% (P<0.05), respectively, and the malondialdehyde (MDA) content was reduced by 31.7% (P<0.05); the T-AOC in jejunal mucosa in the LBP group was increased by 99.1% (P<0.05), and the MDA content was reduced by 13.7% (P<0.05). 3) Compared with the control group, the contents of interleukin-2 (IL-2) and interleukin-10 (IL-10) in jejunal mucosa in the LBP group were increased by 31.6% (P<0.05) and 66.0% (P<0.05), respectively. 4) Compared with the control group, the contents of immunoglobulin M and immunoglobulin G in jejunal mucosa in the LBP group were increased by 33.7% (P<0.05) and 35.1% (P<0.05), respectively. 5) Compared with the control group, the villi height of jejunum in the LBP group showed an upward trend, the crypt depth showed a downward trend, and the villi height/crypt depth (V/C) was significantly increased (P<0.05). It is concluded that adding LBP to the diet of weaned rats can improve the antioxidant capacity and immune function of jejunal mucosa, improve the morphology of jejunum, and them improve the growth performance of weaned rats.

Cite this article

YIN Yexin , WANG Fang , YU Dongming , WANG Xin , FU Chenxing , CHEN Jiashun . Effects of Dietary Lycium barbarum Polysaccharide on Growth Performance, Antioxidant Capacity, Intestinal Mucosal Immune Function and Intestinal Morphology of Weaned Rats[J]. Chinese Journal of Animal Nutrition, 2021 , 33(4) : 2302 -2310 . DOI: 10.3969/j.issn.1006-267x.2021.04.048

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