[1] RUI L Y,XIE M H,HU B,et al.Enhanced solubility and antioxidant activity of chlorogenic acid-chitosan conjugates due to the conjugation of chitosan with chlorogenic acid[J].Carbohydrate Polymers,2017,170:206-216.
[2] LOU L X,LIU Y J,ZHOU J W,et al.Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1β-induced fibroblast-like synoviocytes through regulating the activation of NF-κB and JAK/STAT-signaling pathways[J].Immunopharmacology and Immunotoxicology,2015,37(6):499-507.
[3] ZHANG Z,WU X Y,CAO S Y,et al.Chlorogenic acid ameliorates experimental colitis by promoting growth of
Akkermansia in mice[J].Nutrients,2017,9(7):677.
[4] PLEŠKO S,VOLK H,LUKŠIČ M,et al.
In silico study of plant polyphenols' interactions with VP24-Ebola virus membrane-associated protein[J].Acta Chimica Slovenica,2015,62(3):555-564.
[5] GOUTHAMCHANDRA K,SUDEEP H V,VENKATESH B J,et al.Chlorogenic acid complex (CGA7),standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells[J].Food Science and Human Wellness,2017,6(3):147-153.
[6] NAVEED M,HEJAZI V,ABBAS M,et al.Chlorogenic acid (CGA):a pharmacological review and call for further research[J].Biomedicine and Pharmacotherapy,2018,97:67-74.
[7] LIU H W,ZHAO J S,LI K,et al.Effects of chlorogenic acids-enriched extract from
Eucommia ulmoides leaves on growth performance,stress response,antioxidant status and meat quality of lambs subjected or not to transport stress[J].Animal Feed Science and Technology,2018,238:47-56.
[8] SUN Z L,ZHANG X X,WU H H,et al.Antibacterial activity and action mode of chlorogenic acid against
Salmonella Enteritidis,a foodborne pathogen in chilled fresh chicken[J].World Journal of Microbiology and Biotechnology,2020,36:24.
[9] MEINHART A D,DAMIN F M,CALDEIRÃO L,et al.Study of new sources of six chlorogenic acids and caffeic acid[J].Journal of Food Composition and Analysis,2019,82:103244.
[10] PAYEN S.Memoire sur le café (3° part)[J].Comptes Rendus,1846(23):244-251.
[11] GORTER K.Coffee[J].Justus Liebig's Annalen der Chemie,1908(358):327-348.
[12] CLIFFORD M N,JOHNSTON K L,KNIGHT S,et al.Hierarchical scheme for LC-MSn identification of chlorogenic acids[J].Journal of Agriculture and Food Chemistry,2003,51(10):2900-2911.
[13] LEE B,LEE D G.Depletion of reactive oxygen species induced by chlorogenic acid triggers apoptosis-like death in
Escherichia coli[J].Free Radical Research,2018,52(5):605-615.
[14] 国家林业局.全国杜仲产业发展规划(2016-2030年)[R].北京:国家林业局,2016. SFA.National development plan of
Eucommia ulmoides (2016-2030)[R].Beijing:The State Forestry Administration of China,2016.(in Chinese)
[15] 王娟娟,秦雪梅,高晓霞,等.杜仲化学成分、药理活性和质量控制现状研究进展[J].中草药,2017,48(15):3228-3237. WANG J J,QIN X M,GAO X X,et al.Research progress on chemical compounds,pharmacological action,and quality status of
Eucommia ulmoides[J].Chinese Herbal Medicines,2017,48(15):3228-3237.(in Chinese)
[16] 胡青平,徐建国,李琪,等.酶法提取元宝枫叶绿原酸的新工艺研究[J].食品科学,2006,27(7):159-162. HU Q P,XU J G,LI Q,et al.Study on new extraction technology of chlorgenic acid in
Acer truncatum Bunge leaf with enzyme treatment[J].Food Science,2006,27(7):159-162.(in Chinese)
[17] MCCLEMENTS D J.Encapsulation,protection,and release of hydrophilic active components:potential and limitations of colloidal delivery systems[J].Advances in Colloid and Interface Science,2015,219:27-53.
[18] FARRELL T L,DEW T P,POQUET L,et al.Absorption and metabolism of chlorogenic acids in cultured gastric epithelial monolayers[J].Drug Metabolism and Disposition,2011,39(12):2338-2346.
[19] LI L,SU C P,CHEN X Y,et al.Chlorogenic acids in cardiovascular disease:a review of dietary consumption,pharmacology,and pharmacokinetics[J].Journal of Agricultural and Food Chemistry,2020,68(24):6464-6484.
[20] STALMACH A,MULLEN W,BARRON D,et al.Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans:identification of biomarkers of coffee consumption[J].Drug Metabolism and Disposition,2009,37(8):1749-1758.
[21] CLIFFORD M N,KERIMI A,WILLIAMSON G.Bioavailability and metabolism of chlorogenic acids (acyl-quinic acids) in humans[J].Comprehensive Reviews in Food Science and Food Safety,2020,19(3):1299-1352.
[22] SOVA M,SASO L.Natural sources,pharmacokinetics,biological activities and health benefits of hydroxycinnamic acids and their metabolites[J].Nutrients,2020,12(8):2190.
[23] CLIFFORD M N,JAGANATH I B,LUDWIG I A,et al.Chlorogenic acids and the acyl-quinic acids:discovery,biosynthesis,bioavailability and bioactivity[J].Natural Product Reports,2017,34(12):1391-1421.
[24] TAJIK N,TAJIK M,MACK I,et al.The potential effects of chlorogenic acid,the main phenolic components in coffee,on health:a comprehensive review of the literature[J].European Journal of Nutrition,2017,56(7):2215-2244.
[25] DE OLIVEIRA D M,SAMPAIO G R,PINTO C B,et al.Bioavailability of chlorogenic acids in rats after acute ingestion of mate tea (
Ilex paraguariensis) or 5-caffeoylquinic acid[J].European Journal of Nutrition,2017,56(8):2541-2556.
[26] MONTEIRO M,FARAH A,PERRONE D,et al.Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans[J].The Journal of Nutrition,2007,137(10):2196-2201.
[27] DEL RIO D,STALMACH A,CALANI L,et al.Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols[J].Nutrients,2010,2(8):820-833.
[28] MIAO M S,XIANG L L.Pharmacological action and potential targets of chlorogenic acid[J].Advances in Pharmacology,2020,87:71-88.
[29] GUENGERICH F P.Cytochrome P4502E1 and its roles in disease[J].Chemico-Biological Interactions,2020,322:109056.
[30] EID A A,GORIN Y,FAGG B M,et al.Mechanisms of podocyte injury in diabetes role of cytochrome P450 and NADPH oxidases[J].Diabetes,2009,58(5):1201-1211.
[31] LIU Y Y,ZHAI T,YU Q Q,et al.Effect of high exposure of chlorogenic acid on lipid accumulation and oxidative stress in oleic acid-treated HepG2 cells[J].Chinese Herbal Medicines,2018,10(2):199-205.
[32] WEI M J,ZHENG Z Y,SHI L,et al.Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway[J].Toxicological Sciences,2018,162(1):99-112.
[33] MIAO H,ZHANG Y,HUANG Z L,et al.
Lonicera japonica attenuates carbon tetrachloride-induced liver fibrosis in mice:molecular mechanisms of action[J].The American Journal of Chinese Medicine,2019,47(2):351-367.
[34] SHIN H S,SATSU H,BAE M J,et al.Catechol groups enable reactive oxygen species scavenging-mediated suppression of PKD-NF kappa B-IL-8 signaling pathway by chlorogenic and caffeic acids in human intestinal cells[J].Nutrients,2017,9(2):165.
[35] ZHAO J S,DENG W,LIU H W.Effects of chlorogenic acid-enriched extract from
Eucommia ulmoides leaf on performance,meat quality,oxidative stability,and fatty acid profile of meat in heat-stressed broilers[J].Poultry Science,2019,98(7):3040-3049.
[36] CHEN J L,LI Y,YU B,et al.Dietary chlorogenic acid improves growth performance of weaned pigs through maintaining antioxidant capacity and intestinal digestion and absorption function[J].Journal of Animal Science,2018,96(3):1108-1118.
[37] TANAKA T,NARAZAKI M,KISHIMOTO T J I.Immunotherapeutic implications of IL-6 blockade for cytokine storm[J].Immuontherapy,2016,8(8):959-970.
[38] ZHANG L,FAN Y,SU H W,et al.Chlorogenic acid methyl ester exerts strong anti-inflammatory effects
via inhibiting the COX-2/NLRP3/NF-κB pathway[J].Food & Function,2018,9(12):6155-6164.
[39] ZAMANI-GARMSIRI F,GHASEMPOUR G,ALIABADI M,et al.Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high-fat diet fed mice[J].International Union of Biochemistry and Molecular Biology Life,2020,doi:10.1002/iub.2424.
[40] GAO R F,YANG H D,JING S F,et al.Protective effect of chlorogenic acid on lipopolysaccharide-induced inflammatory response in dairy mammary epithelial cells[J].Microbial Pathogenesis,2018,124:178-182.
[41] BAO L P,LI J S,ZHA D Q,et al.Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-κB pathways[J].International Immunopharmacology,2018,54:245-253.
[42] ZHAO X L,YU L,ZHANG S D,et al.Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages[J].International Immunopharmacology,2020,83:106436.
[43] GAO W Y,WANG C H,YU L,et al.Chlorogenic acid attenuates dextran sodium sulfate-induced ulcerative colitis in mice through MAPK/ERK/JNK pathway[J].Biomed Research International,2019,2019:6769789.
[44] TAN S R,YAN F,LI Q R,et al.Chlorogenic acid promotes autophagy and alleviates
Salmonella typhimurium infection through the lncRNAGAS5/miR-23a/PTEN axis and the p38 MAPK pathway[J].Frontiers in Cell and Develpomental Biology,2020,8:552020.
[45] CHAI B B,JIANG W J,HU M,et al.
In vitro synergistic interactions of protocatechuic acid and chlorogenic acid in combination with antibiotics against animal pathogens[J].Synergy,2019,9:100055.
[46] GONG X X,SU X S,ZHAN K,et al.The protective effect of chlorogenic acid on bovine mammary epithelial cells and neutrophil function[J].Journal of Dairy Science,2018,101(11):10089-10097.
[47] CHEN J L,YU B,CHEN D W,et al.Changes of porcine gut microbiota in response to dietary chlorogenic acid supplementation[J].Applied Microbiology and Biotechnology,2019,103(19):8157-8168.
[48] PENG M J,WANG Z H,PENG S,et al.Dietary supplementation with the extract from
Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets[J].PLoS One,2019,14(9):e0223002.
[49] SU M M,LIU F,LUO Z,et al.The antibacterial activity and mechanism of chlorogenic acid against foodborne pathogen pseudomonas aeruginosa[J].Foodborne Pathogens and Disease,2019,16(12):823-830.
[50] NAKAMURA K,ISHIYAMA,SHENG H,et al.Bactericidal activity and mechanism of photoirradiated polyphenols against gram-positive and-negative bacteria[J].Journal of Agricultural and Food Chemistry,2015,63(35):7707-7713.
[51] GUAN S S,ZHU K T,DONG Y J,et al.Exploration of binding mechanism of a potential
Streptococcus pneumoniae neuraminidase inhibitor from herbaceous plants by molecular simulation[J].International Journal of Molecualr Science,2020,21(3):1003.
[52] KARAR M G E,MATEI M F,JAISWAL R,et al.Neuraminidase inhibition of dietary chlorogenic acids and derivatives-potential antivirals from dietary sources[J].Food & Function,2016,7(4):2052-2059.
[53] SINISI V,STEVAERT A,BERTI F,et al.Chlorogenic compounds from coffee beans exert activity against respiratory viruses[J].Planta Medica,2017,83(7):615-623.
[54] PRINSLOO G,VERVOORT J.Identifying anti-HSV compounds from unrelated plants using NMR and LC-MS metabolomic analysis[J].Metabolomics,2018,14(10):134.
[55] SILVA-BELTRAN N P,CHAIDEZ-QUIROZ C,LOPEZ-CUEVAS O,et al.Phenolic compounds of potato peel extracts:their antioxidant activity and protection against human enteric viruses[J].Journal of Microbiology and Biotechnology,2017,27(2):234-241.
[56] INOUE M,TSUGANE S.Coffee drinking and reduced risk of liver cancer:update on epidemiological findings and potential mechanisms[J].Current Nutrition Reports,2019,8(3):182-186.
[57] IKEDA K,TSUJIMOTO K,UOZAKI M,et al.Inhibition of multiplication of herpes simplex virus by caffeic acid[J].International Journal of Molecular Medicine,2011,28(4):595-598.
[58] XUE N N,ZHOU Q,JI M,et al.Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype[J].Scientific Reports,2017,7:39011.
[59] HUANG S,WANG L L,XUE N N,et al.Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation[J].Theranostics,2019,9(23):6745-6763.
[60] HOU N,LIU N,HAN J,et al.Chlorogenic acid induces reactive oxygen species generation and inhibits the viability of human colon cancer cells[J].Anti-Cancer Drugs,2017,28(1):59-65.
[61] YAMAGATA K,IZAWA Y,ONODERA D,et al.Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells[J].Molecular and Cellular Biochemistry,2018,441(1/2):9-19.
[62] CHEN J L,YU B,CHEN D W,et al.Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs[J].The Journal of Nutritional Biochemistry,2018,59:84-92.
[63] 王宇,周选武,陈代文,等.绿原酸对仔猪生长性能、血清免疫球蛋白及肠道黏膜形态与消化吸收能力的影响[J].动物营养学报,2018,30(3):1136-1145. WANG Y,ZHOU X W,CHEN D W,et al.Effects of chlorogenic acid on growth performance,serum immunolobulins,intestinal mucosa morphology,digestive and absorptive capacity of piglets[J].Chinese Journal of Animal Nutrition,2018,30(3):1136-1145.(in Chinese)
[64] ZHANG Y,WANG Y,CHEN D W,et al.Dietary chlorogenic acid supplementation affects gut morphology,antioxidant capacity and intestinal selected bacterial populations in weaned piglets[J].Food & Function,2018,9(9):4968-4978.
[65] NGUYEN T V,TANIHARA F,DO L T K,et al.Chlorogenic acid supplementation during
in vitro maturation improves maturation,fertilization and developmental competence of porcine oocytes[J].Reproduction in Domestic Animals,2017,52(6):969-975.
[66] NGUYEN T V,WITTAYARAT M,DO L T K,et al.Effects of chlorogenic acid (CGA) supplementation during
in vitro maturation culture on the development and quality of porcine embryos with electroporation treatment after
in vitro fertilization[J].Animal Science Journal,2018,89(8):1207-1213.
[67] NAMULA Z,HIRATA M,WITTAYARAT M,et al.Effects of chlorogenic acid and caffeic acid on the quality of frozen-thawed boar sperm[J].Reproduction in Domestic Animals,2018,53(6):1600-1604.
[68] PEREIRA B A,CHAVES B R,TELES M C,et al.Chlorogenic acid improves the quality of boar semen subjected to cooled storage at 15℃[J].Andrologia,2018,50(5):e12978.
[69] BONGARTZ V,BÖTTGER C,WILHELMY N,et al.Protection of protein from ruminal degradation by alkali-induced oxidation of chlorogenic acid in sunflower meal[J].Journal of Animal Physiology and Animal Nutrition,2018,102(1):e209-e215.
[70] OH N S,LEE J Y,OH S,et al.Improved functionality of fermented milk is mediated by the synbiotic interaction between
Cudrania tricuspidata leaf extract and
Lactobacillus gasseri strains[J].Applied Microbiology and Biotechnology,2016,100(13):5919-5932.
[71] CARRANZA A D V,SARAGUSTI A,CHIABRANDO G A,et al.Effects of chlorogenic acid on thermal stress tolerance in
C. elegans via HIF-1,HSF-1 and autophagy[J].Phytomedicine,2020,66:153132.
[72] CHENG X,LI K,XU S S,et al.Applying chlorogenic acid in an alginate scaffold of chondrocytes can improve the repair of damaged articular cartilage[J].PLoS One,2018,13(4):e0195326.
[73] WANG G F,SHI L P,REN Y D,et al.Anti-hepatitis B virus activity of chlorogenic acid,quinic acid and caffeic acid
in vivo and
in vitro[J].Antiviral Research,2009,83(2):186-190.
