[1] 李敏利,汪芳裕,张晓华,等.肠道微生态与胃肠道疾病关系的研究进展[J].江苏医药,2019,45(3):291-294. LI M L,WANG F Y,ZHANG X H,et al.Research progress on the relationship between intestinal microecology and gastrointestinal diseases[J].Jiangsu Medicine,2019,45(3):291-294. (in Chinese)
[2] YAMASHIRO Y.Gut microbiota in health and disease[J].Annals of Nutrition and Metabolism,2017,71(3/4):242-246.
[3] ZMORA N,SUEZ J,ELINAV E.You are what you eat:diet,health and the gut microbiota[J].Nature Reviews Gastroenterology & Hepatology,2019,16(1):35-56.
[4] EL KAOUTARI A,ARMOUGOM F,GORDON J I,et al.The abundance and variety of carbohydrate-active enzymes in the human gut microbiota[J].Nature Reviews Microbiology,2013,11(7):497-504.
[5] SUAREZ F,FURNE J,SPRINGFIELD J,et al.Insights into human colonic physiology obtained from the study of flatus composition[J].American Journal of Physiology,1997,272(5):G1028-G1033.
[6] PIMENTEL M,MATHUR R,CHANG C.Gas and the microbiome[J].Current Gastroenterology Reports,2013,15(12):356.
[7] MACONI G,FURFARO F,FRIES W,et al.Intestinal gas and liver steatosis:a casual association? A prospective multicentre assessment[J].Liver International,2017,37(1):141-147.
[8] GASBARRINI A,CORAZZA G R,GASBARRINI G,et al.Methodology and indications of H
2-breath testing in gastrointestinal diseases:the Rome consensus conference[J].Alimentary Pharmacology & Therapeutics,2009,29(Suppl.1):1-49.
[9] FRANKLIN B.Fart proudly:writings of benjamin franklin you never read in school[M].[s.l.]:North Atlantic Books,2019.
[10] MACFARLANE G T,GIBSON G R.Carbohydrate fermentation,energy transduction and gas metabolism in the human large intestine[M]//MACKIE R I,WHITE B A.Gastrointestinal microbiology.Boston,MA:Springer,1997.
[11] LEVITT M D.Volume and composition of human intestinal gas determined by means of an intestinal washout technic[J].New England Journal of Medicine,1971,284(25):1394-1398.
[12] SAHAKIAN A B,JEE S R,PIMENTEL M.Methane and the gastrointestinal tract[J].Digestive Diseases and Sciences,2010,55(8):2135-2143.
[13] LEVITT M D,BOND J H,Jr.Volume,composition,and source of intestinal gas[J].Gastroenterology,1970,59(6):921-929.
[14] MODAK A S.Stable isotope breath tests in clinical medicine:a review[J].Journal of Breath Research,2007,1(1):014003.
[15] 顾海莺,陆敏.结肠镜检查中采用二氧化碳送气装置注入CO
2进镜时间及安全性观察[J].现代仪器与医疗,2019,25(6):64-66. GU H Y,LU M.Observation on the time and safety of using carbon dioxide gas device to inject CO
2 into the lens during colonoscopy[J].Modern Instruments and Medical,2019,25(6):64-66. (in Chinese)
[16] CHRISTMAN N T,HAMILTON L H.A new chromatographic instrument for measuring trace concentrations of breath-hydrogen[J].Journal of Chromatography B:Biomedical Sciences and Applications,1982,229(2):259-265.
[17] METZ G,GASSULL M A,LEEDS A R,et al.A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling[J].Clinical Science and Molecular Medicine,1976,50(3):237-240.
[18] WOLF P G,BISWAS A,MORALES S E,et al.H
2 metabolism is widespread and diverse among human colonic microbes[J].Gut Microbes,2016,7(3):235-245.
[19] CARBONERO F,BENEFIEL A C,GASKINS H R.Contributions of the microbial hydrogen economy to colonic homeostasis[J].Nature Reviews Gastroenterology & Hepatology,2012,9(9):504-518.
[20] LOUIS P,HOLD G L,FLINT H J.The gut microbiota,bacterial metabolites and colorectal cancer[J].Nature Reviews Microbiology,2014,12(10):661-672.
[21] NAKAMURA N,LIN H C,MCSWEENEY C S,et al.Mechanisms of microbial hydrogen disposal in the human colon and implications for health and disease[J].Annual Review of Food Science and Technology,2010,1:363-395.
[22] MASSET J,CALUSINSKA M,HAMILTON C,et al.Fermentative hydrogen production from glucose and starch using pure strains and artificial co-cultures of
Clostridium spp.[J].Biotechnology for Biofuels,2012,5:35.
[23] KALANTAR-ZADEH K,BEREAN K J,BURGELL R E,et al.Intestinal gases:influence on gut disorders and the role of dietary manipulations[J].Nature Reviews Gastroenterology & Hepatology,2019,16(12):733-747.
[24] HEDDERICH R,WHITMAN W B.Physiology and biochemistry of the methane-producing archaea[M]//DWORKIN M,FALKOW S,ROSENBERG E,et al.The prokaryotes.New York,NY:Springer,2006,2:1050-1079.
[25] HOFFMANN C.Integrating the archaea,bacteria and fungi of the gut microbiome with human diet[M].Goiânia:Universidade Federal De Goiás,2013.
[26] LUO Y H,CHEN H,YU B,et al.Dietary pea fiber increases diversity of colonic methanogens of pigs with a shift from
Methanobrevibacter to
Methanomassiliicoccus-like genus and change in numbers of three hydrogenotrophs[J].BMC Microbiology,2017,17:17.
[27] LUO Y H,ZHANG L,LI H,et al.Different types of dietary fibers trigger specific alterations in composition and predicted functions of colonic bacterial communities in BALB/c mice[J].Frontiers in Microbiology,2017,8:966.
[28] 葛婷,慕春龙,朱伟云.人肠道产甲烷菌与肠道健康[J].微生物学报,2015,55(6):661-666. GE T,MU C L,ZHU W Y.Human intestinal methanogens and intestinal health[J].Acta microbiologica Sinica,2015,55(6):661-666. (in Chinese)
[29] DE MACARIO E C,MACARIO A J L.Methanogenic archaea in health and disease:a novel paradigm of microbial pathogenesis[J].International Journal of Medical Microbiology,2009,299(2):99-108.
[30] 许宝孝,张达荣,苏皖文,等.肠道疾病患者粪便中的产甲烷菌[J].微生物学报,1991,31(6):473-478. XU B X,ZHANG D R,SU W W.Methanogens in the stool of patients with intestinal diseases[J].Acta Microbiologica Sinica,1991,31(6):473-478. (in Chinese)
[31] MILLION M,ALOU M T,KHELAIFIA S,et al.Increased gut redox and depletion of anaerobic and methanogenic prokaryotes in severe acute malnutrition[J].Scientific Reports,2016,6:26051.
[32] CHAUDHARY P P,CONWAY P L,SCHLUNDT J.Methanogens in humans:potentially beneficial or harmful for health[J].Applied Microbiology and Biotechnology,2018,102(7):3095-3104.
[33] ARMOUGOM F,HENRY M,VIALETTES B,et al.Monitoring bacterial community of human gut microbiota reveals an increase in
Lactobacillus in obese patients and
Methanogens in anorexic patients[J].PLoS One,2009,4(9):e7125.
[34] SAMUEL B S,GORDON J I.A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(26):10011-10016.
[35] DIBAISE J K,ZHANG H S,CROWELL M D,et al.Gut microbiota and its possible relationship with obesity[J].Mayo Clinic Proceedings,2008,83(4):460-469.
[36] PIMENTEL M,GUNSALUS R P,RAO S S C,et al.Methanogens in human health and disease[J].The American Journal of Gastroenterology Supplements,2012,1(1):28-33.
[37] SCANLAN P D,SHANAHAN F,MARCHESI J R.Human methanogen diversity and incidence in healthy and diseased colonic groups using
mcrA gene analysis[J].BMC Microbiology,2008,8:79.
[38] TRIANTAFYLLOU K,CHANG C,PIMENTEL M.Methanogens,methane and gastrointestinal motility[J].Journal of Neurogastroenterology and Motility,2014,20(1):31-40.
[39] GIBSON G R,MACFARLANE S,MACFARLANE G T.Metabolic interactions involving sulphate-reducing and methanogenic bacteria in the human large intestine[J].FEMS Microbiology Ecology,1993,12(2):117-125.
[40] WANG R.Two's company,three's a crowd:can H
2S be the third endogenous gaseous transmitter?[J].The FASEB Journal,2002,16(13):1792-1798.
[41] BUKOVSKA G,KERY V,KRAUS J P.Expression of human cystathionine β-synthase in
Escherichia coli:purification and characterization[J].Protein Expression and Purification,1994,5(5):442-448.
[42] ERICKSON P F,MAXWELL I H,SU L J,et al.Sequence of cDNA for rat cystathionine γ-lyase and comparison of deduced amino acid sequence with related
Escherichia coli enzymes[J].Biochemical Journal,1990,269(2):335-340.
[43] STIPANUK M H,BECK P W.Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat[J].Biochemical Journal,1982,206(2):267-277.
[44] BLACHIER F,BEAUMONT M,KIM E.Cysteine-derived hydrogen sulfide and gut health:a matter of endogenous or bacterial origin[J].Current Opinion in Clinical Nutrition and Metabolic Care,2019,22(1):68-75.
[45] ROEDIGER W E W.Review article:nitric oxide from dysbiotic bacterial respiration of nitrate in the pathogenesis and as a target for therapy of ulcerative colitis[J].Alimentary Pharmacology & Therapeutics,2008,27(7):531-541.
[46] ROEDIGER W E,MOORE J,BABIDGE W.Colonic sulfide in pathogenesis and treatment of ulcerative colitis[J].Digestive Diseases and Sciences,1997,42(8):1571-1579.
[47] HUYCKE M M,GASKINS H R.Commensal bacteria,redox stress,and colorectal cancer:mechanisms and models[J].Experimental Biology and Medicine,2004,229(7):586-597.
[48] ATTENE-RAMOS M S,WAGNER E D,PLEWA M J,et al.Evidence that hydrogen sulfide is a genotoxic agent[J].Molecular Cancer Research,2006,4(1):9-14.
[49] ATTENE-RAMOS M S,WAGNER E D,GASKINS H R,et al.Hydrogen sulfide induces direct radical-associated DNA damage[J].Molecular Cancer Research,2007,5(5):455-459.
[50] TOMASOVA L,KONOPELSKI P,UFNAL M.Gut bacteria and hydrogen sulfide:the new old players in circulatory system homeostasis[J].Molecules,2016,21(11):1558.
[51] GENG B,CHANG L,PAN C S,et al.Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol[J].Biochemical and Biophysical Research Communications,2004,318(3):756-763.
[52] SUN Y G,CAO Y X,WANG W W,et al.Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes[J].Cardiovascular Research,2008,79(4):632-641.
[53] YONG Q C,PAN T T,HU L F,et al.Negative regulation of β-adrenergic function by hydrogen sulphide in the rat hearts[J].Journal of Molecular and Cellular Cardiology,2008,44(4):701-710.
[54] NAGPURE B V,BIAN J S.Interaction of hydrogen sulfide with nitric oxide in the cardiovascular system[J].Oxidative Medicine and Cellular Longevity,2016,2016:6904327.
[55] PEREZ F,ACCARINO A,AZPIROZ F,et al.Gas distribution within the human gut:effect of meals[J].The American Journal of Gastroenterology,2007,102(4):842-849.
[56] MC WILLIAMS S R,MC LAUGHLIN P D,O'CONNOR O J,et al.Computed tomography assessment of intestinal gas volumes in functional gastrointestinal disorders[J].Journal of Neurogastroenterology and Motility,2012,18(4):419-425.
[57] MURRAY K,WILKINSON-SMITH V,HOAD C,et al.Differential effects of FODMAPs (fermentable oligo-,di-,mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI[J].The American Journal of Gastroenterology,2013,109(1):110-119.
[58] LEVITT M D.Production and excretion of hydrogen gas in man[J].The New England Journal of Medicine,1969,281(3):122-127.
[59] BOND J H,Jr.,ENGEL R R,LEVITT M D.Factors influencing pulmonary methane excretion in man:an indirect method of studying the in situ metabolism of the methane-producing colonic Bacteria[J].Journal of Experimental Medicine,1971,133(3):572-588.
[60] JEONG Y D,KO H S,HOSSEINDOUST A,et al.
Lactobacillus-based fermentation product and lactose level in the feed for weanling pigs:effects on intestinal morphology,microbiota,gas emission,and targeted intestinal coliforms[J].Livestock Science,2019,227:90-96.
[61] LIU J B,CAO S C,LIU J,et al.Effect of probiotics and xylo-oligosaccharide supplementation on nutrient digestibility,intestinal health and noxious gas emission in weanling pigs[J].Asian-Australasian Journal of Animal Sciences,2018,31(10):1660-1669.
[62] KALANTAR-ZADEH K,BEREAN K J,HA N,et al.A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gut[J].Nature Electronics,2018,1(1):79-87.
[63] OU J Z,YAO C K,ROTBART A,et al.Human intestinal gas measurement systems:in vitro fermentation and gas capsules[J].Trends in Biotechnology,2015,33(4):208-213.
[64] WU G D,CHEN J,HOFFMANN C,et al.Linking long-term dietary patterns with gut microbial enterotypes[J].Science,2011,334(6052):105-108.
[65] MANICHANH C,ECK A,VARELA E,et al.Anal gas evacuation and colonic microbiota in patients with flatulence:effect of diet[J].Gut,2014,63(3):401-408.
[66] SERRA J.Intestinal gas:has diet anything to do in the absence of a demonstrable malabsorption state?[J].Current Opinion in Clinical Nutrition and Metabolic Care,2012,15(5):489-493.
[67] 中华医学会消化病学分会.肠易激综合征诊治共识意见[J].中华消化杂志,2003,23(7):427. CSGE.Consensus opinions on diagnosis and treatment of irritable bowel syndrome[J].Chinese Journal of Gastroenterology,2003,23(7):427.(in Chinese)
[68] 张子悦,马书进,贺新月,等.肠易激综合征的发病机制及治疗研究进展[J].临床消化病杂志,2019,31(1):60-63. ZHANG Z Y,MA S J,HE X Y,et al.Research progress on the pathogenesis and treatment of irritable bowel syndrome[J].Chinese Journal of Clinical Gastroenterology,2019,31(1):60-63. (in Chinese)
[69] SKOOG S M,BHARUCHA A E,ZINSMEISTER A R.Comparison of breath testing with fructose and high fructose corn syrups in health and IBS[J].Neurogastroenterology & Motility,2008,20(5):505-511.
[70] ONG D K,MITCHELL S B,BARRETT J S,et al.Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome[J].Journal of Gastroenterology and Hepatology,2010,25(8):1366-1373.
[71] HERNOT D C,BOILEAU T W,BAUER L L,et al.
In vitro fermentation profiles,gas production rates,and microbiota modulation as affected by certain fructans,galactooligosaccharides,and polydextrose[J].Journal of Agricultural and Food Chemistry,2009,57(4):1354-1361.
[72] SHEPHERD S J,LOMER M C,GIBSON P R.Short-chain carbohydrates and functional gastrointestinal disorders[J].American Journal of Gastroenterology,2013,108(5):707-717.
[73] ESWARAN S,MUIR J,CHEY W D.Fiber and functional gastrointestinal disorders[J].American Journal of Gastroenterology,2013,108(5):718-727.
[74] BRINKWORTH G D,NOAKES M,CLIFTON P M,et al.Comparative effects of very low-carbohydrate,high-fat and high-carbohydrate,low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations[J].British Journal of Nutrition,2009,101(10):1493-1502.
[75] CANI P D,AMAR J,IGLESIAS M A,et al.Metabolic endotoxemia initiates obesity and insulin resistance[J].Diabetes,2007,56(7):1761-1772.
[76] EL KAOUTARI A,ARMOUGOM F,LEROY Q,et al.Development and validation of a microarray for the investigation of the CAZymes encoded by the human gut microbiome[J].PLOS ONE,2013,8(12):e84033.
[77] GIBSON P R,SHEPHERD S J.Evidence-based dietary management of functional gastrointestinal symptoms:the FODMAP approach[J].2010,25(2):252-258.
[78] ONG D K,MITCHELL S B,SMITH S C,et al.The intestinal fermentative response to dietary FODMAPs:failure to switch to methane production in patients with irritable bowel syndrome[J].Journal of Gastroenterology and Hepatology,2008,23:A219.
[79] BARRETT J S,GEARRY R B,IRVING P M,et al.Dietary poorly absorbed short-chain carbohydrates (FODMAPs) increase the volume and fermentable substrate content of ileal output[J].Gastroenterology,2009,136(Suppl.1):A-135.
[80] RAWLINGS N D,BARRETT A J,FINN R.Twenty years of the MEROPS database of proteolytic enzymes,their substrates and inhibitors[J].Nucleic Acids Research,2015,44(D1):D343-D350.
[81] WINDEY K,DE PRETER V,VERBEKE K.Relevance of protein fermentation to gut health[J].Molecular Nutrition & Food Research,2012,56(1):184-196.
[82] PORTUNE K J,BEAUMONT M,DAVILA A M,et al.Gut microbiota role in dietary protein metabolism and health-related outcomes:the two sides of the coin[J].Trends in Food Science & Technology,2016,57:213-232.
[83] HUGHES R,MAGEE E A,BINGHAM S.Protein degradation in the large intestine:relevance to colorectal cancer[J].Current Issues in Intestinal Microbiology,2000,1(2):51-58.
