Effects of Different Types of Acidifiers on Growth Performance and Immune Function of Weaned Piglets

  • CHENG Yuanzhi ,
  • ZHOU Hongbin ,
  • YU Caihua ,
  • ZHANG Peifa ,
  • LU Zeqing ,
  • WANG Yizhen ,
  • WANG Tenghao
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  • 1. Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China;
    2. Dalian Chengsan Animal Husbandry Co., Ltd., Dalian 116308, China;
    3. Shanghai Xinnong Feed Co., Ltd., Shanghai 201604, China;
    4. Zhejiang Qinglian Food Co., Ltd., Jiaxing 314317, China

Received date: 2020-11-06

  Online published: 2021-05-14

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Abstract

This study was conducted to investigate the effects of different types of acidifiers on growth performance, antioxidant and immune function of weaned piglets. One hundred and sixty-two weaned piglets with body weight of (7.14±0.30) kg were randomly divided into 3 groups with 3 replicates per group and 18 pigs per replicate. Pigs in the control group were fed a basal diet, and those in the experimental groups were fed the basal diets supplemented with 0.2% phosphoric acid acidifier and 0.2% lactic acid acidifier, respectively. The trial lasted for 21 days. The results showed as follows:1) compared with the control group, the average feed intake of weaned piglets in phosphoric acid acidifier group and lactic acid acidifier group was increased by 6.75% and 11.69% (P>0.05), the average daily weight gain was increased by 10.67% and 13.07% (P>0.05), and the feed to gain ratio was decreased by 3.40% and 1.36% (P>0.05), respectively. 2) Compared with the control group, the serum total superoxide dismutase activity of weaned piglets in lactic acid acidifier group was significantly increased (P<0.05), and the serum malondialdehyde content was significantly decreased (P<0.05). 3) Compared with the control group, the serum contents of immunoglobulin G and immunoglobulin A of weaned piglets in the lactic acid acidifier group were significantly increased (P<0.05), and the serum immunoglobulin G content was significantly higher than that in the phosphoric acid acidifier group (P<0.05); the mRNA relative expression levels of interleukin-10 and transforming growth factor-β in duodenum of weaned piglets in the lactic acid acidifier group were significantly increased (P<0.05), and the mRNA relative expression levels of tumor necrosis factor-α and transforming growth factor-β in jejunum were significantly higher than those in the control group and the phosphoric acid acidifier group (P<0.05). In conclusion, both dietary 0.2% phosphoric acid acidifier and 0.2% lactic acid acidifier can enhance the antioxidant and immune function of weaned piglets to a certain extent, also have the trend of improving the growth performance of piglets, and the effects of lactic acid acidifier are better than those of phosphoric acid acidifier.

Cite this article

CHENG Yuanzhi , ZHOU Hongbin , YU Caihua , ZHANG Peifa , LU Zeqing , WANG Yizhen , WANG Tenghao . Effects of Different Types of Acidifiers on Growth Performance and Immune Function of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2021 , 33(5) : 2575 -2584 . DOI: 10.3969/j.issn.1006-267x.2021.05.018

References

[1] WU Y Q,YIN X N,WANG Y L,et al.Effect of 2-hydroxy-4-(methylthio) butanoic acid and acidifier on the performance,chyme pH,and microbiota of broilers[J].Animal Science Journal,2020,91(1):e13409.
[2] JIA G,YAN J Y,CAI J Y,et al.Effects of encapsulated and non-encapsulated compound acidifiers on gastrointestinal pH and intestinal morphology and function in weaning piglets[J].Journal of Animal and Feed Sciences,2010,19(1):81-92.  
[3] KLINSODA J,VÖETTERL J,ZEBELI Q,et al.Lactic acid treatment of cereals and dietary phytase modified fecal microbiome composition without affecting expression of virulence factor genes in growing pigs[J].Frontiers in Microbiology,2019,10:2345.
[4] YI H B,JIANG D H,ZHANG L,et al.Developmental expression of STATs,nuclear factor-κB and inflammatory genes in the jejunum of piglets during weaning[J].International Immunopharmacology,2016,36:199-204.
[5] BURNELL T W,CROMWELL G L,STAHLY T S.Effects of dried whey and copper sulfate on the growth responses to organic acid in diets for weanling pigs[J].Journal of Animal Science,1988,66(5):1100-1108.  
[6] KIL D Y,BI KWON W,KIM B G.Dietary acidifiers in weanling pig diets:a review[J].Revista Colombiana de Ciencias Pecuarias,2011,24(3):231-247.
[7] RISLEY C R,KORNEGAY E T,LINDEMANN M D,et al.Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs[J].Journal of Animal Science,1992,70(1):196-206.  
[8] RADCLIFFE J S,ZHANG Z,KORNEGAY E T.The effects of microbial phytase,citric acid,and their interaction in a corn-soybean meal-based diet for weanling pigs[J].Journal of Animal Science,1998,76(7):1880-1886.  
[9] 李运虎,李美君,彭兰丽,等.不同酸化剂对断奶仔猪胃肠道pH和消化酶活性的影响[J].饲料博览,2019(2):20-23. LI Y H,LI M J,PENG L L,et al.Effect of different acidifiers on gastrointestinal pH value and digestive enzyme activities in weaned piglets[J].Feed Review,2019(2):20-23.(in Chinese)
[10] PARTANEN K H,MROZ Z.Organic acids for performance enhancement in pig diets[J].Nutrition Research Reviews,1999,12(1):117-145.  
[11] 王继华,刘伯.甲酸钙、乳酸钙、柠檬酸钙和柠檬酸对断奶仔猪生长性能的影响[J].饲料研究,2015(8):23-27. WANG J H,LIU B.Effects of calcium formate,calcium lactate,calcium citrate and citric acid on growth performance of weaned piglets[J].Feed Research,2015(8):23-27.(in Chinese)
[12] 李春凤,林显华,谷巍.酸化剂在畜禽生产中的应用[J].中国饲料,2012(22):34-35. LI C F,LIN X H,GU W.Application of Acidifier in livestock and poultry production[J].China Feed,2012(22):34-35.
[13] PARTANEN K,KARHAPÄÄ M,SILJANDER-RASI H,et al.Performance,carcass quality,and gastric alterations in fattening pigs fed additives containing formic acid either coated with sorbate or mixed with lactic acid[J].Agricultural and Food Science,2006,15(3):324-339.
[14] WANG H F,GAO K,WANG C,et al.Effects of feeding bamboo vinegar and acidifier as an antibiotic substitute on the growth performance and intestinal bacterial communities of weaned piglets[J].Acta Agriculturae Scandinavica,Section A:Animal Science,2013,63(3):143-150.
[15] 郑建婷,冯国亮,曹亮,等.柠檬酸对生长肉兔生长性能、养分表观消化率、血清抗氧化指标及肉品质的影响[J].动物营养学报,2020,32(5):2282-2289. ZHENG J T,FENG G L,CAO L,et al.Effects of citric acid on growth performance,nutrient apparent digestibilities,serum antioxidant indexes and meat quality of growth meat rabbits[J].Chinese Journal of Animal Nutrition,2020,32(5):2282-2289.(in Chinese)
[16] 李建平,单安山,徐奇友.不同类型酸化剂对早期断奶仔猪胃酸分泌、免疫功能和抗氧化机能的影响[J].东北农业大学学报,2009,40(4):69-73. LI J P,SHAN A S,XU Q Y.Effects of different acidifiers on gastric acid secretion,immunology and antioxidation of early weaned piglets[J].Journal of Northeast Agricultural University,2009,40(4):69-73.(in Chinese)
[17] 阳巧梅,尹秀娟,廖婵娟.日粮添加酸化剂替代抗生素对断奶仔猪生长性能、血清生化指标及肠道形态的影响[J].中国饲料,2018(10):37-41. YANG Q M,YIN X J,LIAO C J.Effects of organic acid substitute for antibiotic on growth performance,serum biochemistry indices and intestinal morphology of weaning pigs[J].China Feed,2018(10):37-41.(in Chinese)
[18] 李鹏,武书庚,张海军,等.复合酸化剂对断奶仔猪肠黏膜形态和肠道微生物区系及免疫功能的影响[J].中国畜牧杂志,2009,45(9):28-32. LI P,WU S G,ZHANG H J,et al.Effects of acidifiers on small intestine morphology,intestinal microbial flora and immune response of weaned pigs[J].Chinese Journal of Animal Science,2009,45(9):28-32.(in Chinese)
[19] AHMED S T,HWANG J A,HOON J,et al.Comparison of single and blend acidifiers as alternative to antibiotics on growth performance,fecal microflora,and humoral immunity in weaned piglets[J].Asian-Australasian Journal of Animal Sciences,2014,27(1):93-100.  
[20] REDA R M,MAHMOUD R,SELIM K M,et al.Effects of dietary acidifiers on growth,hematology,immune response and disease resistance of Nile tilapia,Oreochromis niloticus[J].Fish & Shellfish Immunology,2016,50:255-262.
[21] YIN F G,FARZAN A,WANG Q,et al.Reduction of Salmonella enterica serovar typhimurium DT104 infection in experimentally challenged weaned pigs fed a Lactobacillus-fermented feed[J].Foodborne Pathogens and Disease,2014,11(8):628-634.  
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