Effects of Dietary Supplementation of Beta-Hydroxy-Beta-Methylbutyrate on Growth Performance and Liver Lipid Metabolism of Bama Xiang Pigs

ZHENG Changbing; SONG Bo; ZHENG Jie; ZHONG Yinzhao; ZHANG Shiyu; DUAN Yehui; YIN Yulong

doi:10.3969/j.issn.1006-267x.2021.06.020

2021 , Vol. 33 >Issue 6: 3176 - 3184

DOI: https://doi.org/10.3969/j.issn.1006-267x.2021.06.020

SWINE NUTRITION AND FEED

Effects of Dietary Supplementation of Beta-Hydroxy-Beta-Methylbutyrate on Growth Performance and Liver Lipid Metabolism of Bama Xiang Pigs

ZHENG Changbing ,
SONG Bo ,
ZHENG Jie ,
ZHONG Yinzhao ,
ZHANG Shiyu ,
DUAN Yehui ,
YIN Yulong

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1. College of Animal Science, South China Agricultural University, Guangzhou 510462, China;
2. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Key Laboratory of Animal Nutritional Physiology and Metabolic Process of Hunan, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

Received date: 2020-12-01

Online published: 2021-06-10

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Abstract

This experiment was conducted to investigate the effects of dietary supplementation of beta-hydroxy-beta-methylbutyrate (HMB) on growth performance and liver lipid metabolism of Bama Xiang pigs. Thirty-two healthy emasculated male Bama Xiang mini-pigs of similar weight[(8.58 ±0.21) kg] and at the age of (60±2) days were selected and randomly divided into 4 groups with 8 pigs per group. Pig in the 4 groups were fed diets which contained 0 (control group), 0.13%, 0.64% and 1.28% HMB for 60 days, respectively. The results showed as follows:1) compared with the control group, dietary supplementation of 0.13% HMB significantly increased the average daily gain and the serum high-density lipoprotein (HDL) content (P<0.05); dietary supplementation of 1.28% HMB supplementation significantly decreased the serum HDL content (P<0.05), and significantly increased the serum cholesterol content (P<0.05). 2) Compared with the control group, dietary supplementation of 0.13% HMB significantly increased the liver docosahexaenoic acid (C22:6n-3) content (P<0.05), and significantly decreased the ratio of n-6/n-3 polyunsaturated fatty acids (PUFA) (P<0.05). 3) Compared with the control group, dietary supplementation of 0.13% HMB significantly increased the mRNA expression levels of fatty acid translocation enzyme (HSL) and peroxisome proliferator-activated receptor α (PPARα) (P<0.05), while dietary supplementation of 1.28% HMB significantly decreased the mRNA expression levels of hormone sensitive lipase (HSL) and fatty acid transporter-1 (FATP-1) (P<0.05). In conclusion, dietary supplementation of HMB (the appropriate level is 0.13%) can improve the growth performance, increase the liver C22:6n-3 content, and improve the liver fat metabolism of Bama Xiang mini-pigs, and the mechanism of action may be related to PPARα signaling pathway.

Key words： beta-hydroxy-beta-methylbutyrate; Bama Xiang pigs; serum biochemical indexes; liver; fatty acids

Cite this article

ZHENG Changbing , SONG Bo , ZHENG Jie , ZHONG Yinzhao , ZHANG Shiyu , DUAN Yehui , YIN Yulong . Effects of Dietary Supplementation of Beta-Hydroxy-Beta-Methylbutyrate on Growth Performance and Liver Lipid Metabolism of Bama Xiang Pigs[J]. Chinese Journal of Animal Nutrition, 2021 , 33(6) : 3176 -3184 . DOI: 10.3969/j.issn.1006-267x.2021.06.020

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