Research Progress on Pathogenesis and Nutritional Regulation of Milk Fever Caused by Hypocalcemia of Dairy Cows

ZHANG Fan; WANG Hui; GUO Yuming; XIONG Benhai

doi:10.3969/j.issn.1006-267x.2021.07.004

Chinese Journal of Animal Nutrition >

2021 , Vol. 33 >Issue 7: 3629 - 3638

DOI: https://doi.org/10.3969/j.issn.1006-267x.2021.07.004

Research Progress on Pathogenesis and Nutritional Regulation of Milk Fever Caused by Hypocalcemia of Dairy Cows

ZHANG Fan ,
WANG Hui ,
GUO Yuming ,
XIONG Benhai

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1. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China

Received date: 2020-12-16

Online published: 2021-07-06

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Abstract

Milk fever, which is also called postpartum paralysis, is a common nutritional and metabolic disease in transition dairy cows. The direct reason is that at the beginning of lactation, a large amount of blood calcium is secreted into the milk, while intestinal absorption and bone calcium mobilization cannot timely supplement the loss of blood calcium, which leads to the decrease of blood calcium level, causing postpartum paralysis in dairy cows. Milk fever mostly occurs in high-yielding postpartum multiparous cows. Clinically, it is characterized by hypocalcemia, muscle weakness, depression and quadriplegia. With the decrease of blood calcium level, it will be accompanied by retained placenta, metritis, displaced abomasum, mastitis, ketosis and other diseases, which greatly increases the culling rate of cows. Therefore, the prevention of milk fever is an important way to improve the economic benefits of dairy farming. The sources of blood calcium in cows include intestinal absorption, bone calcium mobilization and kidney reabsorption. Therefore, it is the key point to prevent milk fever of cows during calving through nutritional regulation measures to increase the blood calcium level of calving cows from the three channels. In this paper, the pathogenesis and nutritional regulation methods of milk fever in dairy cows were reviewed, in order to provide guidance for the prevention of milk fever in dairy cows.

Key words： dairy cows; milk fever; hypocalcemia; postpartum paralysis; dietary cation-anion difference

Cite this article

ZHANG Fan , WANG Hui , GUO Yuming , XIONG Benhai . Research Progress on Pathogenesis and Nutritional Regulation of Milk Fever Caused by Hypocalcemia of Dairy Cows[J]. Chinese Journal of Animal Nutrition, 2021 , 33(7) : 3629 -3638 . DOI: 10.3969/j.issn.1006-267x.2021.07.004

References

[1] REINHARDT T A,LIPPOLIS J D,MCCLUSKEY B J,et al.Prevalence of subclinical hypocalcemia in dairy herds[J].The Veterinary Journal,2011,188(1):122-124.

[2] DEGARIS P J,LEAN I J.Milk fever in dairy cows:a review of pathophysiology and control principles[J].The Veterinary Journal,2008,176(1):58-69.

[3] 隋君霞,丰艳妮,田文儒,等.围产期奶牛低钙血症发病机制研究进展[J].中国兽医杂志,2018,54(11):61-63. SUI J X,FENG Y N,TIAN W R,et al.Progress in the pathogenesis of perinatal hypocalcemia in dairy cows[J].Chinese Journal of Veterinary Medicine,2008,54(11):61-63.(in Chinese)
[4] 谢心美.中国部分规模化牧场奶牛低血钙现状调查分析[J].中国奶牛,2020(8):19-22. XIE X M.Investigation and analysis on the status of hypocalcemia in dairy cows in some large-scale pastures in China[J].China Dairy Cattle,2020(8):19-22.(in Chinese)
[5] MARTÍN-TERESO J,MARTENS H.Calcium and magnesium physiology and nutrition in relation to the prevention of milk fever and tetany (dietary management of macrominerals in preventing disease)[J].Veterinary Clinics of North America:Food Animal Practice,2014,30(3):643-670.

[6] HERNÁNDEZ-CASTELLANO L E,HERNANDEZ L L,BRUCKMAIER R M.Review:endocrine pathways to regulate calcium homeostasis around parturition and the prevention of hypocalcemia in periparturient dairy cows[J].Animal,2020,14(2):330-338.

[7] GOFF J P,HORST R L.Effects of the addition of potassium or sodium, but not calcium, to prepartum rations on milk fever in dairy cows[J].Journal of Dairy Science,1997,80(1):176-186.

[8] 唐波,王群,韩兆玉.不同补钙方式对奶牛产后血液钙和其他几种生化指标的影响[J].南京农业大学学报,2013,36(2):121-124. TANG B,WANG Q,HAN Z Y.Effects of supplementing calcium in different ways on the blood index in postpartum cows[J].Journal of Nanjing Agricultural University,2013,36(2):121-124.(in Chinese)
[9] GOFF J P.Macromineral physiology and application to the feeding of the dairy cow for prevention of milk fever and other periparturient mineral disorders[J].Animal Feed Science and Technology,2006,126(3):237-257.
[10] VAN DE BRAAK A E,KLOOSTER A T V,MALESTEIN A.Influence of a deficient supply of magnesium during the dry period on the rate of calcium mobilisation by dairy cows at parturition[J].Research in Veterinary Science,1987,42(1):101-108.

[11] LIANG D,ARNOLD L M,STOWE C J,et al.Estimating us dairy clinical disease costs with a stochastic simulation model[J].Journal of Dairy Science,2017,100(2):1472-1486.

[12] VENJAKOB P L,PIEPER L,HEUWIESER W,et al.Association of postpartum hypocalcemia with early-lactation milk yield, reproductive performance, and culling in dairy cows[J].Journal of Dairy Science,2018,101(10):9396-9405.

[13] JAWOR P E,HUZZEY J M,LEBLANC S J,et al.Associations of subclinical hypocalcemia at calving with milk yield, and feeding, drinking, and standing behaviors around parturition in Holstein cows[J].Journal of Dairy Science,2012,95(3):1240-1248.

[14] NEVES R C,LENO B M,CURLER M D,et al.Association of immediate postpartum plasma calcium concentration with early-lactation clinical diseases, culling, reproduction, and milk production in Holstein cows[J].Journal of Dairy Science,2018,101(1):547-555.

[15] FLEISCHER P,METZNER M,BEYERBACH M,et al.The relationship between milk yield and the incidence of some diseases in dairy cows[J].Journal of Dairy Science,2001,84(9):2025-2035.

[16] 张子扬,沈泰钰,于洪江,等.亚临床型低血钙症奶牛生产性能及粪污排放特性[J].中国农业科学,2016,49(21):4222-4230. ZHANG Z Y,SHEN T Y,YU H J,et al. A Study on the effect of subclinical hypocalcemia in dairy cows on productivity and manure emission characters[J].Scientia Agricultura Sinica,2016,49(21):4222-4230.(in Chinese)
[17] RODRÍGUEZ E M,ARÍS A,BACH A.Associations between subclinical hypocalcemia and postparturient diseases in dairy cows[J].Journal of Dairy Science,2017,100(9):7427-7434.

[18] CAIXETA L S,OSPINA P A,CAPEL M B,et al.Association between subclinical hypocalcemia in the first 3 days of lactation and reproductive performance of dairy cows[J].Theriogenology,2017,94:1-7.
[19] 张子扬,杨威,沈泰钰,等.奶牛低血钙症流行状况调查[J].中国兽医学报,2017,37(10):1969-1972. ZHANG Z Y,YANG W,SHEN T Y,et al.Investigation on epidemic situation of cow hypocalcemia[J].Chinese Journal of Veterinary Science,2017,37(10):1969-1972.(in Chinese)
[20] CAIXETA L S,OSPINA P A,CAPEL M B,et al.Association between subclinical hypocalcemia in the first 3 days of lactation and reproductive performance of dairy cows[J].Theriogenology,2017,94:1-7.
[21] FUTOSI K,FODOR S,MÓCSAI A.Reprint of neutrophil cell surface receptors and their intracellular signal transduction pathways[J].International Immunopharmacology,2013,17(4):1185-1197.

[22] 郭寒,杨威,陈媛媛,等.奶牛低血钙症降低中性粒细胞上ORAI1蛋白的表达[J].中国兽医学报,2019,39(8):1586-1590. GUO H,YANG W,CHEN Y Y,et al.Cows with hypocalcemia result in the expression decrease of ORAI1 protein on neutrophils[J].Chinese Journal of Veterinary Science,2019,39(8):1586-1590.(in Chinese)
[23] GOFF J P.The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows[J].The Veterinary Journal,2008,176(1):50-57.

[24] GOFF J P,HOHMAN A,TIMMS L L.Effect of subclinical and clinical hypocalcemia and dietary cation-anion difference on rumination activity in periparturient dairy cows[J].Journal of Dairy Science,2020,103(3):2591-2601.

[25] SABORÍO-MONTERO A,VARGAS-LEITÓN B,ROMERO-ZÚÑIGA J J,et al.Risk factors associated with milk fever occurrence in grazing dairy cattle[J].Journal of Dairy Science,2017,100(12):9715-9722.

[26] VALLDECABRES A,SILVA-DEL-RÍO N.Effects of postpartum oral calcium supplementation on milk yield, milk composition, and reproduction in multiparous Jersey and Jersey×Holstein crossbreed cows[J].Journal of Dairy Science,2021,104(1):795-805.

[27] LEAN I J,DEGARIS P J,MCNEIL D M,et al.Hypocalcemia in dairy cows:Meta-analysis and dietary cation anion difference theory revisited[J].Journal of Dairy Science,2006,89(2):669-684.

[28] ROCHE J R,BERRY D P.Periparturient climatic, animal, and management factors influencing the incidence of milk fever in grazing systems[J].Journal of Dairy Science,2006,89(7):2775-2783.

[29] NRC.Nutrient requirements of dairy cattle[S].Washington,D.C.:National Academy of Press,2001.
[30] VALLDECABRES A,PIRES J A A,SILVA-DEL-RÍO N.Cow-level factors associated with subclinical hypocalcemia at calving in multiparous Jersey cows[J].Journal of Dairy Science,2019,102(9):8367-8375.

[31] HENDRIKS S J,HUZZEY J M,KUHN-SHERLOCK B,et al.Associations between lying behavior and activity and hypocalcemia in grazing dairy cows during the transition period[J].Journal of Dairy Science,2020,103(11):10530-10546.

[32] 陈庞.东北地区部分集约化牛场群体代谢病调查研究[D].硕士学位论文.长春:吉林大学,2020. CHEN P.Investigation and study on population metabolic diseases of intensive dairy cow farms in northeast China[D].Master's Thesis.Changchun:Jilin University,2020.(in Chinese)
[33] 赵畅,张江,范子玲,等.血浆TRAP5b在奶牛产后低血钙症发生的风险预警作用[J].中国兽医学报,2019,39(7):1361-1365. ZHAO C,ZHANG J,FAN Z L,et al.Risk prediction of plasma TRAP5b on hypocalcemia postpartum in dairy cows[J].Chinese Journal of Veterinary Science,2019,39(7):1361-1365.(in Chinese)
[34] GUANSHI Z,ELDA D,BURIM N A.Reprint of milk fever in dairy cows is preceded by activation of innate immunity and alterations in carbohydrate metabolism prior to disease occurrence[J].Research in Veterinary Science,2018,116.
[35] TSAI I C,MAYO L M,JONES B W,et al.Precision dairy monitoring technologies use in disease detection:differences in behavioral and physiological variables measured with precision dairy monitoring technologies between cows with or without metritis, hyperketonemia, and hypocalcemia[J].Livestock Science,2021,244:104334.
[36] MARTIN-TERESO J,VERSTEGEN M W A.A novel model to explain dietary factors affecting hypocalcaemia in dairy cattle[J].Nutrition Research Reviews,2011,24(2):228-243.

[37] THILSING-HANSEN T,JORGENSEN R J,OSTERGAARD S.Milk fever control principles:a review[J].Acta Veterinaria Scandinavica,2002,43(1):1-19.

[38] 熊本海,罗清尧,郑姗姗,等.中国饲料成分及营养价值表(2020年第31版)制订说明[J].中国饲料,2020(21):87-97. XIONG B H,LUO Q Y,ZHENG S S,et al.Introduction of tables of feed composition and nutritive values in China(2020 the thirty-first edition)[J].China Feed,2020(21):87-97.(in Chinese)
[39] MARTIN-TERESO J,MARTENS H,DEINER C,et al.Pre-calving feeding of rumen-protected rice bran to multiparous dairy cows improves recovery of calcaemia after calving[J].Journal of Dairy Research,2016,83(3):281-288.

[40] KHACHLOUF K,HAMED H,GDOURA R,et al.Effects of dietary zeolite supplementation on milk yield and composition and blood minerals status in lactating dairy cows[J].Journal of Applied Animal Research,2019,47(1):54-62.

[41] 李鑫垚,杨大盛,凌浩,等.奶牛饲粮阴阳离子平衡的研究进展[J].动物营养学报,2019,31(12):5438-5445. LI X Y,YANG D Z,LING H,et al.Research progress of dietary cation-anion balance in dairy cows[J].Chinese Journal of Animal Nutrition,2019,31(12):5438-5445.(in Chinese)
[42] WILKENS M R,NELSON C D,HERNANDEZ L L,et al.Symposium review:transition cow calcium homeostasis-health effects of hypocalcemia and strategies for prevention[J].Journal of Dairy Science,2020,103(3):2909-2927.

[43] GLOSSON K M,ZHANG X,BASCOM S S,et al.Negative dietary cation-anion difference and amount of calcium in prepartum diets:effects on milk production, blood calcium, and health[J].Journal of Dairy Science,2020,103(8):7039-7054.

[44] GOFF J P,KOSZEWSKI N J.Comparison of 0.46% calcium diets with and without added anions with a 0.7% calcium anionic diet as a means to reduce periparturient hypocalcemia[J].Journal of Dairy Science,2018,101(6):5033-5045.

[45] SANTOS J E P,LEAN I J,GOLDER H,et al.Meta-analysis of the effects of prepartum dietary cation-anion difference on performance and health of dairy cows[J].Journal of Dairy Science,2019,102(3):2134-2154.

[46] 张震宇,李龙瑞,张吉鹍.围产期不同水平阴阳离子差日粮对奶牛生产性能的影响[J].中国奶牛,2018(4):5-9. ZHANG Z Y,LI L R,ZHANG J K.The study on lactation performance of periparturient cows fed diets with varying cation-anion difference[J].China Dairy Cattle,2018(4):5-9.(in Chinese)
[47] LOPERA C,ZIMPEL R,VIEIRA-NETO A,et al.Effects of level of dietary cation-anion difference and duration of prepartum feeding on performance and metabolism of dairy cows[J].Journal of Dairy Science,2018,101(9):7907-7929.

[48] GOFF J P.Invited review:mineral absorption mechanisms, mineral interactions that affect acid-base and antioxidant status, and diet considerations to improve mineral status[J].Journal of Dairy Science,2018,101(4):2763-2813.

[49] GOFF J P,LIESEGANG A,HORST R L.Diet-induced pseudohypoparathyroidism:a hypocalcemia and milk fever risk factor[J].Journal of Dairy Science,2014,97(3):1520-1528.

[50] GOFF J P,HORST R L,JARDON P W,et al.Field trials of an oral calcium propionate paste as an aid to prevent milk fever in periparturient dairy cows[J].Journal of Dairy Science,1996,79(3):378-383.

[51] 侯引绪,刘小明,张京和.两种剂型钙制剂预防奶牛产后低血钙症临床研究试验[J].中国奶牛,2018(1):30-32. HOU Y X,LIU X M, ZHANG J H.Clinical trial on prevention of postpartum hypocalcemia in dairy cows with two forms of calcium[J].China Dairy Cattle,2018(1):30-32.(in Chinese)
[52] PEHRSON B,SVENSSON C,JONSSON M.A comparative study of the effectiveness of calcium propionate and calcium chloride for the prevention of parturient paresis in dairy cows[J].Journal of Dairy Science,1998,81(7):2011-2016.

[53] ZHANG F,NAN X,WANG H,et al.Research on the applications of calcium propionate in dairy cows:a review[J].Animals,2020,10(8):1336.
[54] OETZEL G R.Oral calcium supplementation in peripartum dairy cows[J].Veterinary Clinics of North America:Food Animal Practice,2013,29(2):447-455.

[55] BACHMANN H,LANZ M,KEHRLE S,et al.Effects of a sustained release formulation of 1,25-dihydroxyvitamin D₃-glycosides for milk fever prevention on serum 1,25-dihydroxyvitamin D₃, calcium and phosphorus in dairy cows[J].Journal of Steroid Biochemistry and Molecular Biology,2017,173(SI):301-307.
[56] LITTLEDIKE E T,HORST R L.Vitamin D₃ toxicity in dairy cows[J].Journal of Dairy Science,1982,65(5):749-759.

[57] COHRS I,WILKENS M R,GRVNBERG W.Short communication:effect of dietary phosphorus deprivation in late gestation and early lactation on the calcium homeostasis of periparturient dairy cows[J].Journal of Dairy Science,2018,101(10):9591-9598.

[58] 张志飞.五羟色胺(5-HT)对围产期奶山羊钙循环的影响及其分子机制研究[D].硕士学位论文.杨凌:西北农林科技大学,2018. ZHANG Z F.The effects and molecular mechanisms of 5-HT on calcium metabolism in dairy goats during transition period[D].Master's Thesis.Yangling:Northwest A&F University,2018.(in Chinese)
[59] 桑丹,娜美日嘎,孙海洲,等.5-羟色胺对围产期母羊生产性能及血浆和乳中钙转运相关生化指标的影响[J].动物营养学报,2019,31(7):3174-3180. SANG D,NAMIRGA,SUN H Z,et al.Effects of serotonin on performance and plasma and milk calcium transport related biochemical index of perinatal ewes[J].Journal of Animal Nutrition,2019,31(7):3174-3180.(in Chinese)
[60] HERNÁNDEZ-CASTELLANO L E,HERNANDEZ L L,WEAVER S,et al.Increased serum serotonin improves parturient calcium homeostasis in dairy cows[J].Journal of Dairy Science,2017,100(2):1580-1587.

[61] LAPORTA J,PETERS T L,WEAVER S R,et al.Feeding 5-hydroxy-l-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats[J].Domestic Animal Endocrinology,2013,44(4):176-184.

[62] WEAVER S R,LAPORTA J,MOORE S A E,et al.Serotonin and calcium homeostasis during the transition period[J].Domestic Animal Endocrinology,2016,56:S147-S154.

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