Antioxidative Function and Mechanism of Donkey Milk

  • YUE Yuanxi ,
  • YAN Sumei
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  • Inner Mongolia Key Laboratory of Animal Nutrition and Feed Science, College of Animal Sciences, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2020-12-15

  Online published: 2021-07-06

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Abstract

The ingredients of donkey milk are similar with human milk, which is hypoallergenic, and the donkey milk is an ideal cow milk substitute. Donkey milk is rich in active factors such as lactoferrin, lysozyme, lactoperoxidase and immunoglobulin, that milk is an emerging functional dairy product with antioxidant, anti-tumor, antibacterial and immunity. The antioxidant function of donkey milk is beneficial to establish the oxidative defense for human body. Donkey milk, as a natural antioxidant dairy product, has become a research hotspot of functional food. This review summarized the basic compositions, antioxidant function and mechanism of donkey milk, to provide theoretical reference for the development and utilization of donkey milk.

Cite this article

YUE Yuanxi , YAN Sumei . Antioxidative Function and Mechanism of Donkey Milk[J]. Chinese Journal of Animal Nutrition, 2021 , 33(7) : 3639 -3644 . DOI: 10.3969/j.issn.1006-267x.2021.07.005

References

[1] LI L,LIU X F,GUO H.The nutritional ingredients and antioxidant activity of donkey milk and donkey milk powder[J].Food Science and Biotechnology,2017,27(2):393-400.
[2] TRINCHESE G,CAVALIERE G,DE FILIPPO C,et al.Human milk and donkey milk,compared to cow milk,reduce inflammatory mediators and modulate glucose and lipid metabolism,acting on mitochondrial function and oleylethanolamide levels in rat skeletal muscle[J].Frontiers in Physiology,2018,9:32.
[3] 李时珍.本草纲目(校点本)[M].北京:人民卫生出版社,1982:2781-2782. Li S Z.Compendium of materia medica (reference book)[M].Beijing:People's Medical Publishing House,1982:2781-2782.(in Chinese)
[4] KHAN I T,NADEEM M,IMRAN M,et al.Antioxidant properties of milk and dairy products:a comprehensive review of the current knowledge[J].Lipids in Health and Disease,2019,18:41.
[5] BUČEVIĆ -POPOVIĆ V,DELAŠ I,MEDUGORAC S,et al.Oxidative stability and antioxidant activity of bovine,caprine,ovine and asinine milk[J].International Journal of Dairy Technology,2014,67(3):394-401.  
[6] LIONETTI L,CAVALIERE G,BERGAMO P,et al.Diet supplementation with donkey milk upregulates liver mitochondrial uncoupling,reduces energy efficiency and improves antioxidant and anti-inflammatory defenses in rats[J].Molecular Nutrition & Food Research,2012,56(10):1596-1600.  
[7] POLIDORI P,VINCENZETTI S.Use of donkey milk in children with cow's milk protein allergy[J].Foods,2013,2(2):151-159.  
[8] CLAEYS W L,VERRAES C,CARDOEN S,et al.Consumption of raw or heated milk from different species:an evaluation of the nutritional and potential health benefits[J].Food Control,2014,42:188-201.
[9] GUO H Y,PANG K,ZHANG X Y,et al.Composition,physiochemical properties,nitrogen fraction distribution,and amino acid profile of donkey milk[J].Journal of Dairy Science,2007,90(4):1635-1643.  
[10] MALISSIOVA E,ARSENOS G,PAPADEMAS P,et al.Assessment of donkey milk chemical,microbiological and sensory attributes in Greece and Cyprus[J].International Journal of Dairy Technology,2016,69(1):143-146.  
[11] 李泽鑫.日粮蛋白水平对泌乳驴产奶性能和营养物质消化的影响[D].硕士学位论文.呼和浩特:内蒙古农业大学,2019. LI Z X.Effects of dietary protein levels on milk production and nutrient digestion of lactating donkeys[D].Master's Thesis.Hohhot:Inner Mongolia Agricultural University,2019.(in Chinese)
[12] MARCHIŞ Z,MUREŞAN G,STAN A,et al.Donkey milk chemical composition and the influence of lactation[J].ABAH Bioflux,2015,7(2):196-201.
[13] CUNSOLO V,SALETTI R,MUCCILLI V,et al.Proteins and bioactive peptides from donkey milk:the molecular basis for its reduced allergenic properties[J].Food Research International,2017,99(1):41-57.
[14] MASSOURAS T,TRIANTAPHYLLOPOULOS K A,THEODOSSIOU I.Chemical composition,protein fraction and fatty acid profile of donkey milk during lactation[J].International Dairy Journal,2017,75:83-90.
[15] CONTE F,FOTI M,MALVISI M,et al.Assessment of antibacterial activity of donkey milk lysozyme. Safety and hygiene issues[J].Large Animal Review,2012,18(1):13-16.
[16] BLASI F,MONTESANO D,DE ANGELIS M,et al.Results of stereospecific analysis of triacylglycerol fraction from donkey,cow,ewe,goat and buffalo milk[J].Journal of Food Composition and Analysis,2008,21(1):1-7.  
[17] FANTUZ F,FERRARO S,TODINI L,et al.Donkey milk concentration of calcium,phosphorus,potassium,sodium and magnesium[J].International Dairy Journal,2012,24(2):143-145.  
[18] SALIMEI E,FANTUZ F.Equid milk for human consumption[J].International Dairy Journal,2012,24(2):130-142.  
[19] BHARDWAJ A,KUMARI P,NAYNA V,et al.Estimation of antioxidant potential of indigenous Halari and French Poitu donkey milk by using the total antioxidant capacity and ferric reducing antioxidant power essay[J].Asian Journal of Dairy and Food Research,2019,38(4):307-310.
[20] BEGHELLI D,LUPIDI G,DAMIANO S,et al.Rapid assay to evaluate the total antioxidant capacity in donkey milk and in more common animal milk for human consumption[J].Austin Food Science,2016,1(1):1003.
[21] SIMOS Y,METSIOS A,VERGINADIS I,et al.Antioxidant and anti-platelet properties of milk from goat,donkey and cow:an in vitro,ex vivo and in vivo study[J].International Dairy Journal,2011,21(11):901-906.  
[22] LONGODOR A L,MIREŞAN V,CODEA R A,et al.Antioxidant capacity in donkey milk (Equus asinus) depending on lactation[J].Scientific Bulletin.Series F.Biotechnologies,2019,23:181-185.
[23] PIOVESANA S,CAPRIOTTI A L,CAVALIERE C,et al.Peptidome characterization and bioactivity analysis of donkey milk[J].Journal of Proteomics,2015,119:21-29.
[24] 苏德奇,马龙,杨浩峰.鲜驴乳保健功效的实验研究[C]//中国毒理学会第五次全国学术大会论文集.贵阳:中国毒理学会,2009. SU D Q,MA L,YANG H F.Experimental study on health care effect of fresh donkey milk[C]//Proceedings of the fifth national conference of Chinese Society of Toxicology.Guiyang:Chinese Society of Toxicology,2009.(in Chinese)
[25] PHELAN M,AHERNE-BRUCE S A,O'SULLIVAN D,et al.Potential bioactive effects of casein hydrolysates on human cultured cells[J].International Dairy Journal,2009,19(5):279-285.  
[26] SUETSUNA K,UKEDA H,OCHI H.Isolation and characterization of free radical scavenging activities peptides derived from casein[J].The Journal of Nutritional Biochemistry,2000,11(3):128-131.  
[27] AKAN E.An evaluation of the in vitro antioxidant and antidiabetic potentials of camel and donkey milk peptides released from casein and whey proteins[J].Journal of Food Science and Technology,2020,doi:10.1007/s13197-020-04832-5.
[28] CARTHY T L M,KERRY J P,KERRY J F,et al.Evaluation of the antioxidant potential of natural food/plant extracts as compared with synthetic antioxidants and vitamin E in raw and cooked pork patties[J].Meat Science,2001,58(1):45-52.  
[29] MALACARNE M,CRISCIONE A,FRANCESCHI P,et al.New insights into chemical and mineral composition of donkey milk throughout nine months of lactation[J].Animals,2019,9(12):1161.
[30] CHOE E,MIN D B.Mechanisms of antioxidants in the oxidation of foods[J].Comprehensive Reviews in Food Science and Food Safety,2009,8(4):345-358.  
[31] GONG J,NI L L,WANG D F,et al.Effect of dietary organic selenium on milk selenium concentration and antioxidant and immune status in midlactation dairy cows[J].Livestock Science,2014,170:84-90.
[32] ESPINOSA-DIEZ C,MIGUEL V,MENNERICH D,et al.Antioxidant responses and cellular adjustments to oxidative stress[J].Redox Biology,2015,6:183-197.
[33] HARVEY C J,THIMMULAPPA R K,SINGH A,et al.Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress[J].Free Radical Biology and Medicine,2009,46(4):443-445.  
[34] CONTRERAS A V,TORRES N,TOVAR A R.PPAR-α as a key nutritional and environmental sensor for metabolic adaptation[J].Advances in Nutrition,2013,4(4):439-452.  
[35] SEKULIC-JABLANOVIC M,PETKOVIC V,WRIGHT M B,et al.Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress[J].PLoS One,2017,12(11):e0188596.
[36] FIOCCHI A,BROZEK J,SCHVNEMANN H,et al.World allergy organization (WAO) diagnosis and rationale for action against cow's milk allergy (DRACMA) guidelines[J].World Allergy Organization Journal,2010,3(4):57-161.  
[37] TAFARO A,MAGRONE T,JIRILLO F,et al.Immunological properties of donkey's milk:its potential use in the prevention of atherosclerosis[J].Current Pharmaceutical Design,2007,13(36):3711-3717.  
[38] CARTA G,MURRU E,LISAI S,et al.Dietary triacylglycerols with palmitic acid in the sn-2 position modulate levels of N-acylethanolamides in rat tissues[J].PLoS One,2015,10(3):e0120424,doi:10.1371/journal.pone.0120424.
[39] YVON S,OLIER M,LEVEQUE M,et al.Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice[J].European Journal of Nutrition,2018,57(1):155-166.  
[40] TRINCHESE G,CAVALIERE G,CANANI R B,et al.Human,donkey and cow milk differently affects energy efficiency and inflammatory state by modulating mitochondrial function and gut microbiota[J].The Journal of Nutritional Biochemistry,2015,26(11):1136-1146.  
[41] BRUMINI D,FURLUND C B,COMI I,et al.Antiviral activity of donkey milk protein fractions on echovirus type 5[J].International Dairy Journal,2013,28(2):109-111.  
[42] AKCA C,VATAN O,YILMAZ D,et al.In vitro cytotoxic and genotoxic effects of donkey milk on lung cancer and normal cells lines[J].Czech Academy of Agricultural Sciences,2019,37(1):29-35.
[43] SHARIATIKIA M,BEHBAHANI M,MOHABATKAR H.Anticancer activity of cow,sheep,goat,mare,donkey and camel milks and their caseins and whey proteins and in silico comparison of the caseins[J].Molecular Biology Research Communications,2017,6(2):57-64.
[44] ŠARIĆ L,ŠARIĆ B M,MANDIĆ A I,et al.Antibacterial properties of Domestic Balkan donkeys' milk[J].International Dairy Journal,2012,25(2):142-146.  
[45] CHANDRASHEKAR K M,SHARADA R,ISLOOR S.Microbial profile and antimicrobial effect of donkey milk against staphylococcus aureus[J].International Journal of Current Microbiology and Applied Sciences,2018,7(3):3237-3242.  
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