Research Progress of Dairy Cow Mammary Gland Involution and Its Nutrition Regulation

HUANG Guohao; CHEN Juncai; DONG Guozhong

doi:10.3969/j.issn.1006-267x.2021.07.011

Chinese Journal of Animal Nutrition >

2021 , Vol. 33 >Issue 7: 3693 - 3701

DOI: https://doi.org/10.3969/j.issn.1006-267x.2021.07.011

Research Progress of Dairy Cow Mammary Gland Involution and Its Nutrition Regulation

HUANG Guohao ,
CHEN Juncai ,
DONG Guozhong

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1. College of Animal Science and Technology, Southwest University, Chongqing 400715, China;
2. Laboratory for Bio-Feed and Molecular Nutrition, Southwest University, Chongqing 400715, China;
3. Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, China

Received date: 2020-12-13

Online published: 2021-07-06

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Abstract

Mammary gland involution is one of the most important stages of the dry period. In the process of mammary gland involution, the number of vesicles and lipid droplets in mammary epithelial cells gradually increased, organelle atrophied, cell tight junction permeability increased, milk composition synthesis decreased, cell apoptosis increased. In recent years, more and more studies have paid attention to the mechanism and control measures of mammary gland involution in dry cows. The main reason is that accelerating the early stage of dry period may reduce the risk of intramammary infections in the dry period, and may increase the milk production of short dry dairy cows in the subsequent lactation. Recent studies demonstrated that transforming growth factor-β1 (TGF-β1)/Smad and Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signal pathways play important role in the mammary gland involution, and several nutritional strategies could regulate this process. In this review, the latest research progress of related mechanisms and nutritional regulation of dairy cow mammary gland involution were summarized, which could provide new insights for healthy dairy cow production and for the further mammary gland involution research.

Key words： cow mammary glands; dry period; mammary gland involution; TGF-β1/Smad; JAK/STAT3

Cite this article

HUANG Guohao , CHEN Juncai , DONG Guozhong . Research Progress of Dairy Cow Mammary Gland Involution and Its Nutrition Regulation[J]. Chinese Journal of Animal Nutrition, 2021 , 33(7) : 3693 -3701 . DOI: 10.3969/j.issn.1006-267x.2021.07.011

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