Recent Advances in Epidermal Growth Factor Signal Regulating Renewal and Regeneration of Crypt-Villous Axis

  • XIE Wenwen ,
  • LIU Zhenhua ,
  • ZHANG Dexiang ,
  • WANG Xiuqi
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  • National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China

Received date: 2020-12-13

  Online published: 2021-07-06

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Abstract

The epidermal growth factor (EGF) signal in the intestinal stem cell niche is mainly triggered by the binding of its ligand to epidermal growth factor receptor (EGFR) with intrinsic tyrosine kinase activity, and then transmits mitotic signals from the cell surface to the nucleus through downstream signaling pathways such as phosphatidy-inositol 3-kinases (PI3K)/protein kinase B (Akt) and mitogen-activated protein kinase kinase (MEK)/extracellular regulated protein kinases (ERK), which stimulates the proliferation and differentiation of intestinal stem cells, thus promoting intestinal epithelial renewal and repair after injury. Recent studies have shown that certain nutrients in the intestinal lumen can participate in regulating the homeostasis of the intestinal stem cell niche through different branches of EGF signal to maintain the structural and functional integrity of intestinal mucosa. In this review, we summarized the transduction mechanism of EGF signal in the intestine, and systematically examined the role of EGF signal and its mediated functional amino acids in the renewal and regeneration along crypt-villous axes driven by intestine stem cells, to provide the reference for targeted regulation.

Cite this article

XIE Wenwen , LIU Zhenhua , ZHANG Dexiang , WANG Xiuqi . Recent Advances in Epidermal Growth Factor Signal Regulating Renewal and Regeneration of Crypt-Villous Axis[J]. Chinese Journal of Animal Nutrition, 2021 , 33(7) : 3726 -3734 . DOI: 10.3969/j.issn.1006-267x.2021.07.015

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