Effects of Coated Sodium Butyrate on Immune and Antioxidant Indexes of Weaned Lambs

CHEN Xiang; ZUO Lijun; WANG Kexin; JIA Bin; PAN Chunyuan; JIANG Ning; ZHANG Aizhong

doi:10.3969/j.issn.1006-267x.2021.07.036

Chinese Journal of Animal Nutrition >

2021 , Vol. 33 >Issue 7: 3949 - 3958

DOI: https://doi.org/10.3969/j.issn.1006-267x.2021.07.036

RUMINANT AND HERBIVORE NUTRITION AND FEED

Effects of Coated Sodium Butyrate on Immune and Antioxidant Indexes of Weaned Lambs

CHEN Xiang ,
ZUO Lijun ,
WANG Kexin ,
JIA Bin ,
PAN Chunyuan ,
JIANG Ning ,
ZHANG Aizhong

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1. Key Laboratory of Efficient Utilization of Feed Resources and Nutrition Control in Cold Regions of Heilongjiang Province, College of Animal Science and Technology, Heilongjiang Bayi Land Reclamation University, Daqing 163319, China;
2. Animal Husbandry and Veterinary Branch of Heilongjiang Academy of Agricultural Sciences, Qiqihar 161000, China

Received date: 2020-12-16

Online published: 2021-07-06

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Abstract

This experiment was conducted to study the effects of coated sodium butyrate on the immune and antioxidant indexes of weaned lambs. Twenty-four 42-day-old weaned lambs were randomly divided into 4 groups:blank control group (CON group), antibiotic control group (A CON group), coated sodium butyrate A group (CSB A group) and coated sodium butyrate B group (CSB B group), with 6 replicates in each group. Lambs in the CON group were fed a basal diet without antibiotics, and those in the A CON group were fed the basal diet supplemented with 250 mg/kg flavomycin, while those in the CSB A group and CSB B group were fed the basal diet supplemented with 2 and 3 g/kg coated sodium butyrate, respectively. The pre-trial period lasted for 7 days, and the experiment lasted for 28 days. Three lambs of each group were slaughtered and sampled on the 14th and 28th day of the experiment. The result showed as follows:On the 14th and 28th day of the experiment, compared with the CON group, the liver, spleen and thymus indexes of lambs were increased when diet supplemented with coated sodium butyrate (P>0.05). On the 14th day of the experiment, compared with the CON group, the contents of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in serum of CSB A group and CSB B group were significantly decreased (P<0.05), and the contents of interleukin-2 (IL-2) and malondialdehyde (MDA) in serum of A CON group were significantly decreased (P<0.05); compared with the A CON group, the IL-6 content in CSB A group and CSB B group was significantly decreased (P<0.05). On the 14th and 28th day of the experiment, compared with the CON group, the contents of TNF-α, interleukin-1 (IL-1) and IL-6 in liver were significantly decreased (P<0.05), and the IL-2 content in liver of CSB A group and CSB B group was significantly decreased (P<0.05), while the total antioxidant capacity (T-AOC) and total superoxide dismutase (T-SOD) activity in liver of CSB A group were significantly increased (P<0.05). On the 28th day of the experiment, compared with the CON group, the content of IL-6 in serum of CSB A group was significantly decreased (P<0.05), and the TNF-α content in serum of CSB A group and CSB B group was significantly decreased (P<0.05), while the T-SOD activity in serum of CSB A group and CSB B group was significantly increased (P<0.05); compared with the A CON group, the TNF-α content in serum of CSB B group was significantly decreased (P<0.05), while the T-SOD activity in serum of CSB A group and CSB B group was significantly increased (P<0.05). On the 28th day of the experiment, compared with the CON group, the contents of TNF-α, IL-1 and IL-2 in liver of CSB A group and CSB B group were significantly decreased (P<0.05), which the T-AOC and T-SOD activity in liver of CSB A group and CSB B group were significantly increased (P<0.05). Therefore, the addition of coated sodium butyrate in the diet can inhibit the increase of inflammatory cytokines in serum and liver and enhance the antioxidant capacity of weaned lambs, thus protecting lambs from the negative effects of weaning stress to a certain extent, and 2 g/kg of coated sodium butyrate is more reasonable.

Key words： sodium butyrate; weaned lamb; immune organ index; immune index; antioxidant index

Cite this article

CHEN Xiang , ZUO Lijun , WANG Kexin , JIA Bin , PAN Chunyuan , JIANG Ning , ZHANG Aizhong . Effects of Coated Sodium Butyrate on Immune and Antioxidant Indexes of Weaned Lambs[J]. Chinese Journal of Animal Nutrition, 2021 , 33(7) : 3949 -3958 . DOI: 10.3969/j.issn.1006-267x.2021.07.036

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