Effects of Cupric Citrate on Growth Performance, Intestinal Mucosal Development and Serum Biochemical Indexes of Meat Rabbits

GUO Zhiqiang; HU Haiqiang; XIE Xiaohong; KUANG Liangde; LI Congyan; LEI Min; ZHENG Jie; YANG Rui; LI Minghui

doi:10.3969/j.issn.1006-267x.2021.07.041

2021 , Vol. 33 >Issue 7: 4002 - 4008

DOI: https://doi.org/10.3969/j.issn.1006-267x.2021.07.041

SPECIAL ECONOMIC ANIMAL NUTRITION AND FEED

Effects of Cupric Citrate on Growth Performance, Intestinal Mucosal Development and Serum Biochemical Indexes of Meat Rabbits

GUO Zhiqiang ,
HU Haiqiang ,
XIE Xiaohong ,
KUANG Liangde ,
LI Congyan ,
LEI Min ,
ZHENG Jie ,
YANG Rui ,
LI Minghui

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1. Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Institute of Animal Husbandry Science, Chengdu 610066, China;
2. College of Animal Science and Technology, Southwest University, Chongqing 400715, China

Received date: 2021-01-08

Online published: 2021-07-06

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Abstract

The purpose of this experiment was to investigate the effects of dietary supplementation of cupric citrate on the growth performance, intestinal mucosal development and serum biochemical indexes of meat rabbits. A total of 420 New Zealand meat rabbits at the same weaned age of 28 days were selected and randomly divided into 5 groups, each group had 14 replicates with 6 rabbits (half male and half female) per replicate. Rabbits in the 5 groups were fed experimental diets which supplemented with 0 (control group), 10, 20 mg/kg (as copper) cupric citrate and 20, 150 mg/kg (as copper) copper sulfate based on a basal diet, and the measured copper content in each group was 5.1, 15.6, 25.9, 25.2 and 153.4 mg/kg, respectively. The pre-experimental period lasted for 7 days, and the formal experimental period lasted for 42 days. The results showed as follow:1) compared with the control group, diet supplemented 20 mg/kg cupric citrate could significantly increase the average daily gain (P<0.05), and significantly reduce the feed/gain, mortality rate and diarrhea rate of meat rabbits (P<0.05), and there were no significant difference in above indexes between the 20 mg/kg cupric citrate group and the 150 mg/kg copper sulfate group (P>0.05). 2) Compared with the control group, diet supplemented 20 mg/kg cupric citrate could significantly improve the villi height and villi height/crypt depth in all segments of small intestine (P<0.05), and there was no significant difference in above indexes between the 20 mg/kg cupric citrate group and the 150 mg/kg copper sulfate group (P>0.05). 3) Compared with the control group, diet supplemented 20 mg/kg cupric citrate could significantly increase the activities of copper and zinc superoxide dismutase, copper blue protein, and the contents of insulin and growth hormone in serum of meat rabbits (P<0.05), and there was no significant difference in the activities of copper and zinc superoxide dismutase, copper blue protein and the content of growth hormone in serum between the 20 mg/kg cupric citrate group and the 150 mg/kg copper sulfate group (P>0.05). To sum up, diet supplemented 20 mg/kg can promote the growth of meat rabbits, reduce diarrhea rate and mortality rate, promote intestinal development, and improve serum biochemical indexes, and its efficacy is equivalent with 150 mg/kg copper sulfate.

Key words： cupric citrate; meat rabbits; growth performance; intestinal development; serum biochemical indexes

Cite this article

GUO Zhiqiang , HU Haiqiang , XIE Xiaohong , KUANG Liangde , LI Congyan , LEI Min , ZHENG Jie , YANG Rui , LI Minghui . Effects of Cupric Citrate on Growth Performance, Intestinal Mucosal Development and Serum Biochemical Indexes of Meat Rabbits[J]. Chinese Journal of Animal Nutrition, 2021 , 33(7) : 4002 -4008 . DOI: 10.3969/j.issn.1006-267x.2021.07.041

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