Research Progress on Mechanism of Butyrate in Subacute Ruminal Acidosis and Animal Health

  • ZHU Zhi ,
  • JI Yiqi ,
  • HUANG Wenming ,
  • ZUO Fuyuan
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  • Chongqing Engineering and Technology Research Center for Beef Cattle, Immunology Research Center of Medical Research Institute, College of Animal Science and Technology, Southwest University, Chongqing 402460, China

Received date: 2021-01-07

  Online published: 2021-08-11

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Abstract

Feeding high-grain diets in ruminants can easily induce subacute ruminal acidosis (SARA), leading to reduced feed intake and digestibility, damage to the mucosal barrier of ruminal and intestinal epithelium, liver abscess and inflammation increase. As a fermentation product of microorganisms and an energy source for epithelium, butyrate affects ruminal pH and gastrointestinal microflora, and promotes epithelial growth and development. As a signal molecule, butyrate participates in multiple signal pathways and plays a role in cell function, signal transduction and body immunity and so on. Butyrate activates many transcription factors by activating G protein coupled receptors (GPR), or acts as a histone deacetylase (HDAC) inhibitor in epigenetic regulation of gene expression. This paper reviews the effects of butyrate, especially added in high-grain diets, on ruminant rumen, intestines and liver, as well as the molecular mechanism of action, to provide a theoretical basis for alleviating the harm of SARA.

Cite this article

ZHU Zhi , JI Yiqi , HUANG Wenming , ZUO Fuyuan . Research Progress on Mechanism of Butyrate in Subacute Ruminal Acidosis and Animal Health[J]. Chinese Journal of Animal Nutrition, 2021 , 33(8) : 4201 -4212 . DOI: 10.3969/j.issn.1006-267x.2021.08.001

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