SWINE NUTRITION AND FEED

Effect of Organic Iron on Growth Performance of Pigs: A Meta-Analysis

  • DING Haoxuan ,
  • ZHANG Qian ,
  • FENG Jie
Expand
  • Zhejiang Key Laboratory of Animal Nutrition, Institute of Feed Science, Zhejiang University, Hangzhou 310058, China

Received date: 2021-01-23

  Online published: 2021-08-11

Supported by

 

Abstract

Iron is an essential trace element for animal growth and development. Organic iron has the advantages of efficient absorption, good stability and environmental protection, which has gradually recognized by the market. The purpose of this study was to investigate the effects of dietary supplementation of organic iron or inorganic iron on growth performance of pigs by Meta-analysis. Relative papers of organic iron or inorganic iron on growth performance of pigs were collected in CNKI, PubMed and Web of Science databases (published from January 1, 2001 to December 31, 2020). RevMan was used to analyze the average daily gain (ADG), average daily feed intake (ADFI) and gain to feed ratio (G/F) of pigs. Random-effects model was used to compute the mean difference (MD) and 95% confidence interval (CI). Of the 478 articles identified, 19 articles were eligible and included in the Meta-analysis (n=1 380 pigs). Compared with the inorganic iron, organic iron improved the ADG (MD=7.97 g/d), ADFI (MD=2.03 g/d) and G/F (MD=0.01) of weaned piglets. Compared with inorganic iron, organic iron increased the ADFI (MD=66.13 g/d) and ADG (MD=25.07 g/d) of growing-finishing pigs. Subgroup analysis explained the heterogeneity and funnel plot assessed publication bias. In conclusion, supplementation of organic iron in the diet can improve ADG and ADFI of weaned piglets and growing-finishing pigs more than supplementation of inorganic iron in the same dose, which provides a scientific basis for promoting the use of organic iron.

Cite this article

DING Haoxuan , ZHANG Qian , FENG Jie . Effect of Organic Iron on Growth Performance of Pigs: A Meta-Analysis[J]. Chinese Journal of Animal Nutrition, 2021 , 33(8) : 4353 -4363 . DOI: 10.3969/j.issn.1006-267x.2021.08.016

References

[1] DONG Z L,WAN D,LI G Y,et al.Comparison of oral and parenteral iron administration on iron homeostasis,oxidative and immune status in anemic neonatal pigs[J].Biological Trace Element Research,2020,195(1):117-124.  
[2] 丁浩轩,赵阳,洪作鹏,等.多酚在仔猪铁供给失衡方面的研究进展[J].动物营养学报,2020,33(3):1223-1229. DING H X,ZHAO Y,HONG Z P,et al.Research progress of polyphenols in piglet iron supply imbalance[J].Chinese Journal of Animal Nutrition,2020,33(3):1223-1229.(in Chinese)
[3] ZHUO Z,YU X N,LI S S,et al.Heme and non-heme iron on growth performances,blood parameters,tissue mineral concentration,and intestinal morphology of weanling pigs[J].Biological Trace Element Research,2019,187(2):411-417.  
[4] THOMAZ M C,WATANABE P H,PASCOAL L A F,et al.Inorganic and organic trace mineral supplementation in weanling pig diets[J].Anais da Academia Brasileira de Ciências,2015,87(2):1071-1081.  
[5] KEGLEY E B,SPEARS J W,FLOWERS W L,et al.Iron methionine as a source of iron for the neonatal pig[J].Nutrition Research,2002,22(10):1209-1217.  
[6] 丁浩轩,李海云,冯杰.有机铁在猪和鸡营养中的研究与应用[J].中国畜牧杂志,2019,55(4):7-11. DING H X,LI H Y,FENG J.Research and application of organic iron in pigs and chickens nutrition[J].Chinese Journal of Animal Science,2019,55(4):7-11.(in Chinese)
[7] FANG C L,ZHUO Z,FANG S L,et al.Iron sources on iron status and gene expression of iron related transporters in iron-deficient piglets[J].Animal Feed Science and Technology,2013,182(1/2/3/4):121-125.
[8] MA Y L,LINDEMANN M D,CROMWELL G L,et al.Evaluation of trace mineral source and preharvest deletion of trace minerals from finishing diets for pigs on growth performance, carcass characteristics,and pork quality[J].Journal of Animal Science,2012,90(11):3833-3941.  
[9] LIU B,XIONG P W,CHEN N N,et al.Effects of replacing of inorganic trace minerals by organically bound trace minerals on growth performance,tissue mineral status,and fecal mineral excretion in commercial grower-finisher pigs[J].Biological Trace Element Research,2016,173(2):316-324.  
[10] ETTLE T,SCHLEGEL P,ROTH F X.Investigations on iron bioavailability of different sources and supply levels in piglets[J].Journal of Animal Physiology and Animal Nutrition,2007,92(1):35-43.
[11] MOHER D,SHAMSEER L,CLARKE M,et al.Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement[J].Systematic Reviews,2015,4(1):1.
[12] 徐博成,李智,汪以真,等.抗菌肽对仔猪生长性能、腹泻率和免疫球蛋白水平影响的Meta分析[J].动物营养学报,2020,32(8):3584-3593. XU B C,LI Z,WANG Y Z,et al.Effects of antimicrobial peptides on growth performance,diarrhea rate and immunoglobulin levels of piglets:a Meta-analysis[J].Chinese Journal of Animal Nutrition,2020,32(8):3584-3593.(in Chinese)
[13] XU B C,LI Z,WANG C,et al.Effects of fermented feed supplementation on pig growth performance:a meta-analysis[J].Animal Feed Science and Technology,2020,259:114315.
[14] WAN X,WANG W Q,LIU J M,et al.Estimating the sample mean and standard deviation from the sample size,median,range and/or interquartile range[J].BMC Medical Research Methodology,2014,14:135.
[15] HIGGINS J P T,ALTMAN D G,GØTZSCHE P C,et al.The cochrane collaboration's tool for assessing risk of bias in randomised trials[J].BMJ-British Medical Journal,2011,343:d5928.
[16] ABDEL-RAHMAN O.Smoking and EGFR status may predict outcomes of advanced nsclc treated with PD-(L)1 inhibitors beyond first line:a Meta-analysis[J].The Clinical Respiratory Journal,2018,12(5):1809-1819.  
[17] HIGGINS J,THOMPSON S G,DEEKS J J,et al.Measuring inconsistency in meta-analyses[J].British Medical Journal,2003,327(7414):557-560.  
[18] COCATO M L,DA TRINDADE NETO M A,BERTO D A,et al.Bioavailability of iron in different compounds for piglets weaned at 21 days old[J].Revista Brasileira de Zootecnia-Brazilian Journal of Animal Science,2008,37(12):2129-2135.  
[19] CREECH B L,SPEARS J W,FLOWERS W L,et al.Effect of dietary trace mineral concentration and source (inorganic vs. chelated) on performance,mineral status,and fecal mineral excretion in pigs from weaning through finishing[J].Journal of Animal Science,2004,82(7):2140-2147.  
[20] FENG J,MA W Q,XU Z R,et al.Effects of iron glycine chelate on growth,haematological and immunological characteristics in weanling pigs[J].Animal Feed Science and Technology,2007,134(3/4):261-272.
[21] LUIGGI F G,BERTO D A,MELLO G D,et al.Relative bioavailability of iron from organic sources for weanling piglets[J].Semina:Ciências Agrárias,2014,35(5):2807-2816.  
[22] MARTIN R E,MAHAN D C,HILL G M,et al.Effect of dietary organic microminerals on starter pig performance,tissue mineral concentrations,and liver and plasma enzyme activities[J].Journal of Animal Science,2011,89(4):1042-1055.  
[23] DE MELLO G,BERTO D A,LO TIERZO V,et al.Sources of organic trace minerals in diets for weaned piglets[J].Revista Brasileira de Zootecnia:Brazilian Journal of Animal Science,2012,41(8):1872-1877.  
[24] MUNIZ M H B,BERTO D A,AUGUSTO R M N,et al.Organic and inorganic mineral sources for weanling piglets[J].Ciência Rural,2010,40(10):2163-2168.  
[25] 张文飞,廖志超,管武太,等.甘氨酸亚铁对断奶仔猪生长性能、铁表观消化率及血清铁相关指标的影响[J].动物营养学报,2017,29(6):2071-2077. ZHANG W F,LIAO Z C,GUAN W T,et al.Effects of dietary ferrous glycine sulfate on growth performance,iron apparent digestibility and serum iron related indices of weaned piglets[J].Chinese Journal of Animal Nutrition,2017,29(6):2071-2077.(in Chinese)
[26] APPLE J K,WALLIS-PHELPS W A,MAXWELL C V,et al.Effect of supplemental iron on finishing swine performance,carcass characteristics,and pork quality during retail display[J].Journal of Animal Science,2007,85(3):737-745.  
[27] BURKETT J L,STALDER K J,POWERS W J,et al.Effect of inorganic and organic trace mineral supplementation on the performance,carcass characteristics,and fecal mineral excretion of phase-fed,grow-finish swine[J].Asian-Australasian Journal of Animal Sciences,2009,22(9):1279-1287.  
[28] GOWANLOCK D W,MAHAN D C,JOLLIFF J S,et al.Evaluating the NRC levels of Cu,Fe,Mn,and Zn using organic minerals for grower-finisher swine[J].Journal of Animal Science,2013,91(12):5680-5686.  
[29] 詹康,李艳,包文斌,等.复合氨基酸络合铁、锌对肥育猪生产性能和部分血液生化指标的影响[J].畜牧兽医学报,2014,45(5):769-774. ZHAN K,LI Y,BAO W B,et al.Effect of iron,zinc complex amino acid chelate on growth performance and partial blood biochemical indexes in finishing pigs[J].Chinese Journal of Animal and Veterinary Sciences,2014,45(5):769-774.(in Chinese)
[30] 马莲香,侯川川,何俊娜,等.复合有机微量元素对肥育猪生长性能、血清指标及微量元素减排的影响[J].浙江大学学报(农业与生命科学版),2018,44(2):181-189. MA L,HOU C C,HE J N,et al.Effect of compound organic trace minerals on growth performance,serum indexes and micromineral excretion in fattening pigs[J].Journal of Zhejiang University (Agriculture and Life Sciences),2018,44(2):181-189.(in Chinese)
[31] 贾刚,田刚,方热军,等.单胃动物微量元素营养研究进展[J].动物营养学报,2020,32(10):4659-4673. JIA G,TIAN G,FANG R J,et al.Proceeding of monogastric animal trace elements nutrition[J].Chinese Journal of Animal Nutrition,2020,32(10):4659-4673.(in Chinese)
[32] 李智,徐博成,汪以真.Meta分析在动物生产性能评估中的应用[J].动物营养学报,2020,32(3):1003-1009. LI Z,XU B C,WANG Y Z.Application of Meta-analysis in performance evaluation[J].Chinese Journal of Animal Nutrition,2020,32(3):1003-1009.(in Chinese)
[33] DING H X,YU X N,FENG J.Iron homeostasis disorder in piglet intestine[J].Metallomics,2020,12(10):1494-1507.  
[34] FENG J,MA W Q,XU Z R,et al.The effect of iron glycine chelate on tissue mineral levels,fecal mineral concentration,and liver antioxidant enzyme activity in weanling pigs[J].Animal Feed Science and Technology,2009,150(1/2):106-113.
[35] HERTRAMPF E,OLIVARES M.Iron amino acid chelates[J].International Journal for Vitamin and Nutrition Research,2004,74(6):435-443.  
[36] KISKINI A,ARGIRI K,KALOGEROPOULOS M,et al.Sensory characteristics and iron dialyzability of gluten-free bread fortified with iron[J].Food Chemistry,2007,102(1):309-316.  
Outlines

/