Physiological Functions of Short-Chain Fatty Acids and Their Application in Sow Production

  • CHENG Yating ,
  • KONG Xiangfeng
Expand
  • 1. Hunan Provincial Key Laboratory of Animal Nutrition Physiology and Metabolism Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
    2. University of Chinese Academy of Sciences, Beijing 100049, China

Received date: 2021-03-26

  Online published: 2021-10-16

Supported by

 

Abstract

The digestive tract of animals inhabits a huge number and a wide variety of microbiota. These microbiota can use nutrients in the intestine for anabolism to meet their own growth needs, while producing metabolites, such as short-chain fatty acids (SCFA) and bio-amines, affecting the host's nutrient metabolism, immune activity, and physiological function. Among them, SCFA are the most common microbial fermentation products and can affect the body health of animals from multiple aspects. Therefore, this paper reviews the metabolic process and physiological function of SCFA and their application progress in sow production in order to provide a basis for their application.

Cite this article

CHENG Yating , KONG Xiangfeng . Physiological Functions of Short-Chain Fatty Acids and Their Application in Sow Production[J]. Chinese Journal of Animal Nutrition, 2021 , 33(10) : 5435 -5440 . DOI: 10.3969/j.issn.1006-267x.2021.10.004

References

[1] PLUSKE J R, TURPIN D L, KIM J C.Gastrointestinal tract (gut) health in the young pig[J].Animal Nutrition, 2018, 4(2):187-196.  
[2] SCHNUPF P, GABORIAU-ROUTHIAU V, CERF-BENSUSSAN N.Modulation of the gut microbiota to improve innate resistance[J].Current Opinion in Immunology, 2018, 54:137-144.
[3] LAMICHHANE S, SEN P, DICKENS A M, et al.Gutmetabolome meets microbiome:a methodological perspective to understand the relationship between host and microbe[J].Methods, 2018, 149:3-12.
[4] NOWAK A, LIBUDZISZ Z.Influence of phenol, p-cresol and indole on growth and survival of intestinal lactic acid bacteria[J].Anaerobe, 2006, 12(2):80-84.  
[5] SITTIPO P, LOBIONDA S, CHOI K, et al.Toll-like receptor 2-mediated suppression of colorectal cancer pathogenesis by polysaccharide a from Bacteroidesfragilis[J].Frontiers in Microbiology, 2018, 9:1588.
[6] MACFARLANE S, MACFARLANE G T.Regulation of short-chain fatty acid production[J].The Proceedings of the Nutrition Society, 2003, 62(1):67-72.  
[7] DEN BESTEN G, BLEEKER A, GERDING A, et al.Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation[J].Diabetes, 2015, 64(7):2398-2408.  
[8] SAMUEL B S, SHAITO A, MOTOIKE T, et al.Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41[J].Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(43):16767-16772.  
[9] WONG J M W, DE SOUZA R, KENDALL C WC, et al.Colonichealth:fermentation and short chain fatty acids[J].Journal of Clinical Gastroenterology, 2006, 40(3):235-243.  
[10] VAN IMMERSEEL F, FIEVEZ V, DE BUCK J, et al.Microencapsulated short-chain fatty acids in feed modify colonization and invasion early after infection with Salmonella enteritidis in young chickens[J].Poultry Science, 2004, 83(1):69-74.  
[11] ZHANG Y N, YU K F, CHEN HZ, et al.Caecal infusion of the short-chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model[J].Microbial Biotechnology, 2018, 11(5):859-868.  
[12] SUZUKI T, YOSHIDA S, HARA H.Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability[J].The British Journal of Nutrition, 2008, 100(2):297-305.  
[13] TONG L C, WANG Y, WANG Z B, et al.Propionate ameliorates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress[J].Frontiers in Pharmacology, 2016, 7:253.
[14] GAUDIER E, RIVAL M, BUISINE M P, et al.Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon[J].Physiological Research, 2009, 58(1):111-119.
[15] ZHANG H L, DING Q W, WANG A R, et al.Effects of dietary sodium acetate on food intake, weightgain, intestinal digestive enzyme activities, energy metabolism and gut microbiota in cultured fish:zebrafish as a model[J].Aquaculture, 2020, 523:735188.
[16] 张瑞阳, 孟玲, 李方方, 等.包被丁酸钠对断奶仔猪生长性能, 血清生化指标, 养分表观消化率和粪便微生物菌群的影响[J].动物营养学报, 2019, 31(5):2296-2302. ZHANG R Y, MENG L, LI F F, et al.Effects of coated sodium butyrate on growth performance, serum biochemical indices, nutrient apparent digestibility and fecal microflora population of weaning piglets[J].Chinese Journal of Animal Nutrition, 2019, 31(5):2296-2302.(in Chinese)
[17] HU Z H, GUO Y M.Effects of dietary sodium butyrate supplementation on the intestinal morphological structure, absorptive function and gut flora in chickens[J].Animal Feed Science and Technology, 2007, 132(3/4):240-249.
[18] SINGH N, GURAV A, SIVAPRAKASAM S, et al.Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis[J].Immunity, 2014, 40(1):128-139.  
[19] KALINA U, KOYAMA N, HOSODA T, et al.Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region[J].European Journal of Immunology, 2002, 32(9):2635-2643.  
[20] POSTLER T S, GHOSH S.Understanding the holobiont:how microbial metabolites affect human health and shape the immune system[J].Cell Metabolism, 2017, 26(1):110-130.  
[21] WANG C C, WU H, LIN F H, et al.Sodium butyrate enhances intestinal integrity, inhibits mast cell activation, inflammatory mediator production and JNK signaling pathway in weaned pigs[J].Innate Immunity, 2018, 24(1):40-46.  
[22] KOBAYASHI M, MIKAMI D, UWADA J, et al.A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells[J].Oncotarget, 2018, 9(59):31342-31354.  
[23] CORFE B M.Hypothesis:butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation[J].Molecular BioSystems, 2012, 8(6):1609-1612.  
[24] KUMAR J, RANI K, DATT C.Molecular link between dietary fibre, gutmicrobiota and health[J].Molecular Biology Reports, 2020, 47(8):6229-6237.  
[25] YAMASHITA H, MARUTA H, JOZUKA M, et al.Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic otsuka long-evans tokushima fatty (OLETF) rats[J].Bioscience Biotechnology and Biochemistry, 2009, 73(3):570-576.  
[26] CHAMBERS E S, VIARDOT A, PSICHAS A, et al.Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults[J].Gut, 2015, 64(11):1744-1754.  
[27] AHMED K, TUNARU S, OFFERMANNS S.GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors[J].Trends in Pharmacological Sciences, 2009, 30(11):557-562.  
[28] GAO Z G, YIN J, ZHANG J, et al.Butyrate improves insulin sensitivity and increases energy expenditure in mice[J].Diabetes, 2009, 58(7):1509-1517.  
[29] FROST G, SLEETH M L, SAHURI-ARISOYLU M, et al.The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism[J].Nature Communications, 2014, 5:3611.
[30] DE VADDER F, KOVATCHEVA-DATCHARY P, GONCALVES D, et al.Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits[J].Cell, 2014, 156(1/2):84-96.
[31] DONOHOE D R, GARGE N, ZHANG X X, et al.Themicrobiome and butyrate regulate energy metabolism and autophagy in the mammalian colon[J].Cell Metabolism, 2011, 13(5):517-526.  
[32] 侯嘉, 柘丽, 田丹, 等.母猪妊娠后期日粮添加微囊丁酸钠对母猪繁殖性能的影响[J].中国畜牧杂志, 2020, 56(6):111-113. HOU J, ZHE L, TIAN D, etal.The effect of adding microcapsulated sodium butyrate to sows'reproductive performance in late pregnancy[J].Chinese Journal of Animal Science, 2020, 56(6):111-113.(in Chinese)
[33] JANG Y D, LINDEMANN M D, MONEGUE H J, et al.The effect of coated sodium butyrate supplementation in sow and nursery diets on lactation performance and nursery pig growth performance[J].Livestock Science, 2017, 195:13-20.
[34] 吴当当.母猪日粮添加粗纤维和丁酸钠对其繁殖性能、行为及初乳成分的影响[D].硕士学位论文.南京:南京农业大学, 2016:35-42. WU D D.The effects of maternal crude fiber and sodium butyrate supplement on sows reproductive performances, behavior and the colostrum composition[D].Master's Thesis.Nanjing:Nanjing Agricultural University, 2016:35-42.(in Chinese)
[35] 章利丰, 王志刚, 王雯熙, 等.微囊丁酸钠对种母猪繁殖性能及哺乳仔猪生产性能的影响[J].中国畜牧杂志, 2014, 50(12):70-73. ZHANG L F, WANG Z G, WANG W X, et al.Effect of microencapsulated sodium butyrate on reproductive performance of breeding sows and production performance of piglets[J].Chinese Journal of Animal Science, 2014, 50(12):70-73.(in Chinese)
[36] LU H, SU S, AJUWON K M.Butyrate supplementation to gestating sows and piglets induces muscle and adipose tissue oxidative genes and improves growth performance[J].Journal of Animal Science, 2012, 90(Suppl.4):430-432.
[37] HE B, WANG M, GUO H, et al.Effects of sodium butyrate supplementation on reproductive performance and colostrum composition in gilts[J].Animal, 2016, 10(10):1722-1727.  
Outlines

/