[1] DUIN E C,WAGNER T,SHIMA S,et al.Mode of action uncovered for the specific reduction of methane emissions from ruminants by the small molecule 3-nitrooxypropanol[J].Proceedings of the National Academy of Sciences of the United States of America,2016,113(22):6172-6177.
[2] LLONCH P,HASKELL M J,DEWHURST R J,et al.Current available strategies to mitigate greenhouse gas emissions in livestock systems:an animal welfare perspective[J].Animal,2017,11(2):274-284.
[3] ANDERSON R C,HUWE J K,SMITH D J,et al.Effect of nitroethane,dimethyl-2-nitroglutarate and 2-nitro-methyl-propionate on ruminal methane production and hydrogen balance
in vitro[J].Bioresource Technology,2010,101(14):5345-5349.
[4] ANDERSON R C,RASMUSSEN M A.Use of a novel nitrotoxin metabolizing bacterium to reduce ruminal methane production. Bioresource Technology,1998,64(2):89-95.
[5] VYAS D,MCGINN S M,DUVAL S M,et al.Optimal dose of 3-nitrooxypropanol for decreasing enteric methane emissions from beef cattle fed high-forage and high-grain diets[J].Animal Production Science,2016,58(6):1049-1055.
[6] OCHOA-GARCÍA P A,AREVALOS-SÁNCHEZ M M,RUIZ-BARRERA O,et al.
In vitro reduction of methane production by 3-nitro-1-propionic acid is dose-dependent1[J].Journal of Animal Science,2019,97(3):1317-1324.
[7] ZHANG Z W,WANG Y L,CHEN Y Y,et al.Nitroethanol in comparison with monensin exhibits greater feed efficiency through inhibiting rumen methanogenesis more efficiently and persistently in feedlotting lambs[J].Animals,2019,9(10):784.
[8] SMITH D J,ANDERSON R C.Toxicity and metabolism of nitroalkanes and substituted nitroalkanes[J].Journal of Agricultural and Food Chemistry,2013,61(4):763-779.
[9] ANDERSON R C,MAJAK W,RASSMUSSEN M A,et al.Toxicity and metabolism of the conjugates of 3-nitropropanol and 3-nitropropionic acid in forages poisonous to livestock[J].Journal of Agricultural and Food Chemistry,2005,53(6):2344-2350.
[10] 张振威,王彦芦,赵宇琼,等.硝基化合物抑制瘤胃发酵甲烷生成的机理研究进展[J].中国畜牧杂志,2017,53(3):3-8. ZHANG Z W,WANG Y L,ZHAO Y Q,et al.Research progress on inhibition of the effects of nitro-compounds on methane production from rumen fermentation and its mechanism[J].Chinese Journal of Animal Science,2017,53(3):3-8.(in Chinese)
[11] ANDERSON R C,CALLAWAY T R,VAN KESSEL J A S,et al.Effect of select nitrocompounds on ruminal fermentation;an initial look at their potential to reduce economic and environmental costs associated with ruminal methanogenesis[J].Bioresource Technology,2003,90(1):59-63.
[12] GUTIERREZ-BAÑUELOS H,ANDERSON R C,CARSTENS G E,et al.Effects of nitroethane and monensin on ruminal fluid fermentation characteristics and nitrocompound-metabolizing bacterial populations[J].Journal of Agricultural and Food Chemistry,2008,56(12):4650-4658.
[13] BOŽIC A K,ANDERSON R C,CARSTENS G E,et al.Effects of the methane-inhibitors nitrate,nitroethane,lauric acid,Lauricidin and the Hawaiian marine algae Chaetoceros on ruminal fermentation
in vitro[J].Bioresource Technology,2009,100(17):4017-4025.
[14] ZHOU Z M,MENG Q X,YU Z T.Effects of methanogenic inhibitors on methane production and abundances of methanogens and cellulolytic bacteria in
in vitro ruminal cultures[J].Applied and Environmental Microbiology,2011,77(8):2634-2639.
[15] ZHANG Z W,WANG Y L,WANG W K,et al.The inhibitory action mode of nitrocompounds on
in vitro rumen methanogenesis:a comparison of nitroethane,2-nitroethanol and 2-nitro-1-propanol[J].The Journal of Agricultural Science,2019,157(6):471-479.
[16] ZHANG Z W,CAO Z J,WANG Y L,et al.Nitrocompounds as potential methanogenic inhibitors in ruminant animals:a review[J].Animal Feed Science and Technology,2017,236:107-114.
[17] SOLIVA C R,AMELCHANKA S L,DUVAL S M,et al.Ruminal methane inhibition potential of various pure compounds in comparison with garlic oil as determined with a rumen simulation technique (Rusitec)[J].The British Journal of Nutrition,2011,106(1):114-122.
[18] MARTÍNEZ-FERNÁNDEZ G,ABECIA L,ARCO A,et al.Effects of ethyl-3-nitrooxy propionate and 3-nitrooxypropanol on ruminal fermentation,microbial abundance,and methane emissions in sheep[J].Journal of Dairy Science,2014,97(6):3790-3799.
[19] REYNOLDS C K,HUMPHRIES D J,KIRTON P,et al.Effects of 3-nitrooxypropanol on methane emission,digestion,and energy and nitrogen balance of lactating dairy cows[J].Journal of Dairy Science,2014,97(6):3777-3789.
[20] HAISAN J,SUN Y,GUAN L L,et al.The effects of feeding 3-nitrooxypropanol on methane emissions and productivity of Holstein cows in mid lactation[J].Journal of Dairy Science,2014,97(5):3110-3119.
[21] HRISTOV A N,OH J,GIALLONGO F,et al.An inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production[J].Proceedings of the National Academy of Sciences of the United States of America,2015,112(34):10663-10668.
[22] ROMERO-PEREZ A,OKINE E K,MCGINN S M,et al.The potential of 3-nitrooxypropanol to lower enteric methane emissions from beef cattle[J].Journal of Animal Science,2014,92(10):4682-4693.
[23] JIN W,MENG Z X,WANG J,et al.Effect of nitrooxy compounds with different molecular structures on the rumen methanogenesis,metabolic profile,and methanogenic community[J].Current Microbiology,2017,74(8):891-898.
[24] MARSH C D,CLAWSON A B.
Astragalus tetrapterus,a new poisonous plant of Utah and Nevada[M].Washington, D.C.:U.S. Dept. of Agriculture,1920.
[25] STERMITZ F R,NORRIS F A,WILLIAMS M C.Miserotoxin,new naturally occurring nitro compound[J].Journal of the American Chemical Society,1969,91(16):4599-4600.
[26] JAMES L F,HARTLEY W J,WILLIAMS M C,et al.Field and experimental studies in cattle and sheep poisoned by nitro-bearing
Astragalus or their toxins[J].American Journal of Veterinary Research,1980,41(3):377-382.
[27] GREGORY N G,ORBELL G M,HARDING D R.Poisoning with 3-nitropropionic acid in possums (
Trichosurus vulpecula)[J].New Zealand Veterinary Journal,2000,48(3):85-87.
[28] GUSTINE D L.Aliphatic nitro compounds in crownvetch:a review[J].Crop Science,1979,19(2):197-203.
[29] MAJAK W,PASS M A,MADRYGA F J.Toxicity of miserotoxin and its aglycone (3-nitropropanol) to rats[J].Toxicology Letters,1983,19(1/2):171-178.
[30] ANDERSON R C,KRUEGER N A,STANTON T B,et al.Effects of select nitrocompounds on
in vitro ruminal fermentation during conditions of limiting or excess added reductant[J].Bioresource Technology,2008,99(18):8655-8661.
[31] ANDERSON R C,CARSTENS G E,MILLER R K,et al.Effect of oral nitroethane and 2-nitropropanol administration on methane-producing activity and volatile fatty acid production in the ovine rumen[J].Bioresource Technology,2006,97(18):2421-2426.
[32] MAJAK W,CHENG K J.Identification of rumen bacteria that anaerobically degrade aliphatic nitrotoxins[J].Canadian Journal of Microbiology,1981,27(7):646-650.
[33] ZHANG Z W,WANG Y L,WANG W K,et al.The antimethanogenic nitrocompounds can be cleaved into nitrite by rumen microorganisms:a comparison of nitroethane,2-nitroethanol,and 2-nitro-1-propanol[J].Metabolites,2019,10(1):15.
[34] ANDERSON R C,RASMUSSEN M A,ALLISON M J.Metabolism of the plant toxins nitropropionic acid and nitropropanol by ruminal microorganisms[J].Applied and Environmental Microbiology,1993,59(9):3056-3061.
[35] MACHLE W,SCOTT E W,TREON J F.Metabolism of mononitroparaffins:recovery of nitroethane from animal organism[J].The Journal of Industrial Hygiene and Toxicology,1942,24:5-9.
[36] SCOTT E W.The metabolism of mononitroparaffins.Ⅱ.The metabolic products of nitroethane[J].The Journal of Industrial Hygiene and Toxicology,1942,24:226-228.
[37] SCOTT E W.The metabolism of mononitroparaffins.Ⅲ.The concentration of nitroethane,nitrite and nitrate in the blood of rabbits during exposure by inhalation and oral administration[J].The Journal of Industrial Hygiene and Toxicology,1943,25:20-25.
[38] VALIAUGA B,MISEVIČIENĒ L,RICH M H,et al.Mechanism of two-/four-electron reduction of nitroaromatics by oxygen-insensitive nitroreductases:the role of a non-enzymatic reduction step[J].Molecules,2018,23(7):1672.
